Atypical Mutation in Neisseria gonorrhoeae 23S rRNA Associated with High-Level Azithromycin Resistance

Atypical Mutation in Neisseria gonorrhoeae 23S rRNA Associated with High-Level Azithromycin Resistance

A2059G mutation in the 23S rRNA gene is the only reported mechanism conferring high-level azithromycin resistance (HL-AZMR) in Neisseria gonorrhoeae. Through U.S. gonococcal antimicrobial resistance surveillance projects, we identified four HL-AZMR gonococcal isolates lacking this mutational genotyp...

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Veröffentlicht in:Antimicrobial agents and chemotherapy 2021-01, Vol.65 (2), Article 00885
Hauptverfasser: Pham, Cau D., Nash, Evelyn, Liu, Hsi, Schmerer, Matthew W., Sharpe, Samera, Woods, Grace, Roland, Brad, Schlanger, Karen, St Cyr, Sancta B., Carlson, Jonathan, Sellers, Kevin, Olsen, Aaron, Sanon, Ruth, Hardin, Henrietta, Soge, Olusegun O., Raphael, Brian H., Kersh, Ellen N.
Format: Artikel
Sprache:eng
Schlagworte:
Life Sciences & Biomedicine
Mechanisms of Resistance
Microbiology
Pharmacology & Pharmacy
Science & Technology
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Zusammenfassung:A2059G mutation in the 23S rRNA gene is the only reported mechanism conferring high-level azithromycin resistance (HL-AZMR) in Neisseria gonorrhoeae. Through U.S. gonococcal antimicrobial resistance surveillance projects, we identified four HL-AZMR gonococcal isolates lacking this mutational genotype. Genetic analysis revealed an A2058G mutation of 23S rRNA alleles in all four isolates. In vitro selected gonococcal strains with homozygous A2058G recapitulated the HLAZMR phenotype. Taken together, we postulate that the A2058G mutation confers HL-AZMR in N. gonorrhoeae.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.00885-20