RING-finger protein 5 promotes hepatocellular carcinoma progression and predicts poor prognosis
Hepatocellular carcinoma (HCC) is one of the most common cause of malignancy-related deaths. Recently, RING-finger protein 5 (RNF5), an E3 ubiquitin ligase, was revealed to be associated with the development of several human cancers. However, the clinical implication and functional role of RNF5 in H...
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| Veröffentlicht in: | Human cell : official journal of Human Cell Research Society 2021-03, Vol.34 (2), p.530-538 |
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| container_title | Human cell : official journal of Human Cell Research Society |
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| creator | Zhang, Yi Li, Jie Chen, Huayang Zhang, Changmao You, Song Zhao, Yue Lin, Xiaoning Yu, Yaqi Fang, Fei Fang, Ting Wang, Xiaomin |
| description | Hepatocellular carcinoma (HCC) is one of the most common cause of malignancy-related deaths. Recently, RING-finger protein 5 (RNF5), an E3 ubiquitin ligase, was revealed to be associated with the development of several human cancers. However, the clinical implication and functional role of RNF5 in HCC are poorly understood. We analysed RNF5 expression in HCC samples and observed that both the mRNA and protein levels of RNF5 were significantly increased in HCC tissues. RNF5 upregulation was markedly associated with larger tumour size, more satellite foci, and higher alpha fetoprotein (AFP) level, indicating poor prognosis in patients with HCC. Knockdown and overexpression experiments demonstrated that RNF5 promoted the proliferation, migration, and invasion of HCC cells in vitro. Moreover, RNF5 facilitated HCC growth in vivo. Our findings indicated that RNF5 was an oncogene of HCC progression and could be used as a novel prognostic biomarker and therapeutic target for patients with HCC. |
| doi_str_mv | 10.1007/s13577-020-00460-5 |
| format | Article |
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Recently, RING-finger protein 5 (RNF5), an E3 ubiquitin ligase, was revealed to be associated with the development of several human cancers. However, the clinical implication and functional role of RNF5 in HCC are poorly understood. We analysed RNF5 expression in HCC samples and observed that both the mRNA and protein levels of RNF5 were significantly increased in HCC tissues. RNF5 upregulation was markedly associated with larger tumour size, more satellite foci, and higher alpha fetoprotein (AFP) level, indicating poor prognosis in patients with HCC. Knockdown and overexpression experiments demonstrated that RNF5 promoted the proliferation, migration, and invasion of HCC cells in vitro. Moreover, RNF5 facilitated HCC growth in vivo. Our findings indicated that RNF5 was an oncogene of HCC progression and could be used as a novel prognostic biomarker and therapeutic target for patients with HCC.</description><identifier>ISSN: 0914-7470</identifier><identifier>ISSN: 1749-0774</identifier><identifier>EISSN: 1749-0774</identifier><identifier>DOI: 10.1007/s13577-020-00460-5</identifier><identifier>PMID: 33469898</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Biomedical and Life Sciences ; Cell Biology ; Cell proliferation ; Gynecology ; Hepatocellular carcinoma ; Life Sciences ; Life Sciences & Biomedicine ; Liver cancer ; Malignancy ; mRNA ; Oncology ; Prognosis ; Proteins ; Reproductive Medicine ; Research Article ; Science & Technology ; Stem Cells ; Surgery ; Tumors ; Ubiquitin ; Ubiquitin-protein ligase</subject><ispartof>Human cell : official journal of Human Cell Research Society, 2021-03, Vol.34 (2), p.530-538</ispartof><rights>Japan Human Cell Society 2021</rights><rights>Japan Human Cell Society 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>8</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000608971600001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c399t-3d7e9725a988c67134199231479e99ce6545ec65921bc08f9e3900fd22dad90f3</citedby><cites>FETCH-LOGICAL-c399t-3d7e9725a988c67134199231479e99ce6545ec65921bc08f9e3900fd22dad90f3</cites><orcidid>0000-0002-9645-8475</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13577-020-00460-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13577-020-00460-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,39263,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33469898$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Yi</creatorcontrib><creatorcontrib>Li, Jie</creatorcontrib><creatorcontrib>Chen, Huayang</creatorcontrib><creatorcontrib>Zhang, Changmao</creatorcontrib><creatorcontrib>You, Song</creatorcontrib><creatorcontrib>Zhao, Yue</creatorcontrib><creatorcontrib>Lin, Xiaoning</creatorcontrib><creatorcontrib>Yu, Yaqi</creatorcontrib><creatorcontrib>Fang, Fei</creatorcontrib><creatorcontrib>Fang, Ting</creatorcontrib><creatorcontrib>Wang, Xiaomin</creatorcontrib><title>RING-finger protein 5 promotes hepatocellular carcinoma progression and predicts poor prognosis</title><title>Human cell : official journal of Human Cell Research Society</title><addtitle>Human Cell</addtitle><addtitle>HUM CELL</addtitle><addtitle>Hum Cell</addtitle><description>Hepatocellular carcinoma (HCC) is one of the most common cause of malignancy-related deaths. Recently, RING-finger protein 5 (RNF5), an E3 ubiquitin ligase, was revealed to be associated with the development of several human cancers. However, the clinical implication and functional role of RNF5 in HCC are poorly understood. We analysed RNF5 expression in HCC samples and observed that both the mRNA and protein levels of RNF5 were significantly increased in HCC tissues. RNF5 upregulation was markedly associated with larger tumour size, more satellite foci, and higher alpha fetoprotein (AFP) level, indicating poor prognosis in patients with HCC. Knockdown and overexpression experiments demonstrated that RNF5 promoted the proliferation, migration, and invasion of HCC cells in vitro. Moreover, RNF5 facilitated HCC growth in vivo. Our findings indicated that RNF5 was an oncogene of HCC progression and could be used as a novel prognostic biomarker and therapeutic target for patients with HCC.</description><subject>Biomedical and Life Sciences</subject><subject>Cell Biology</subject><subject>Cell proliferation</subject><subject>Gynecology</subject><subject>Hepatocellular carcinoma</subject><subject>Life Sciences</subject><subject>Life Sciences & Biomedicine</subject><subject>Liver cancer</subject><subject>Malignancy</subject><subject>mRNA</subject><subject>Oncology</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>Reproductive Medicine</subject><subject>Research Article</subject><subject>Science & Technology</subject><subject>Stem Cells</subject><subject>Surgery</subject><subject>Tumors</subject><subject>Ubiquitin</subject><subject>Ubiquitin-protein ligase</subject><issn>0914-7470</issn><issn>1749-0774</issn><issn>1749-0774</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><recordid>eNqNkV9rFTEQxYNY7LX6BXyQBV8ESZ382WTzKBethWKh6HPIzc5eU-4m12SX4rc3260VfBCfMoHfnDlzhpBXDM4ZgH5fmGi1psCBAkgFtH1CNkxLQ0Fr-ZRswDBJtdRwSp6XcluhVir-jJwKIZXpTLch9ubyywUdQtxjbo45TRhi0y7VWOvSfMejm5LHw2E-uNx4l32IaXQLsc9YSkixcbGvf-yDn0pzTOleaR9TCeUFORncoeDLh_eMfPv08ev2M726vrjcfriiXhgzUdFrNJq3znSdV5oJyYzhgklt0BiPqpUtetUaznYeusGgMABDz3nvegODOCNvV906-ceMZbJjKIttFzHNxfKqJDlUmYq--Qu9TXOO1V2l6lBgSolK8ZXyOZWScbDHHEaXf1oGdonfrvHbGr-9j98u0q8fpOfdiP1jy--8K_BuBe5wl4biA0aPjxgAKOiMZqpWwCrd_T-9DZOb6jW2aY5TbRVra6n4ctw_S_7D_y8NQbBp</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Zhang, Yi</creator><creator>Li, Jie</creator><creator>Chen, Huayang</creator><creator>Zhang, Changmao</creator><creator>You, Song</creator><creator>Zhao, Yue</creator><creator>Lin, Xiaoning</creator><creator>Yu, Yaqi</creator><creator>Fang, Fei</creator><creator>Fang, Ting</creator><creator>Wang, Xiaomin</creator><general>Springer Singapore</general><general>Springer Nature</general><general>Springer Nature B.V</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9645-8475</orcidid></search><sort><creationdate>20210301</creationdate><title>RING-finger protein 5 promotes hepatocellular carcinoma progression and predicts poor prognosis</title><author>Zhang, Yi ; 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Recently, RING-finger protein 5 (RNF5), an E3 ubiquitin ligase, was revealed to be associated with the development of several human cancers. However, the clinical implication and functional role of RNF5 in HCC are poorly understood. We analysed RNF5 expression in HCC samples and observed that both the mRNA and protein levels of RNF5 were significantly increased in HCC tissues. RNF5 upregulation was markedly associated with larger tumour size, more satellite foci, and higher alpha fetoprotein (AFP) level, indicating poor prognosis in patients with HCC. Knockdown and overexpression experiments demonstrated that RNF5 promoted the proliferation, migration, and invasion of HCC cells in vitro. Moreover, RNF5 facilitated HCC growth in vivo. 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| subjects | Biomedical and Life Sciences Cell Biology Cell proliferation Gynecology Hepatocellular carcinoma Life Sciences Life Sciences & Biomedicine Liver cancer Malignancy mRNA Oncology Prognosis Proteins Reproductive Medicine Research Article Science & Technology Stem Cells Surgery Tumors Ubiquitin Ubiquitin-protein ligase |
| title | RING-finger protein 5 promotes hepatocellular carcinoma progression and predicts poor prognosis |
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