Homeostatic Regulation of ROS-Triggered Hippo-Yki Pathway via Autophagic Clearance of Ref(2)P/p62 in the Drosophila Intestine

Homeostasis of intestinal epithelia is maintained by coordination of the proper rate of regeneration by stem cell division with the rate of cell loss. Regeneration of host epithelia is normally quiescent upon colonization of commensal bacteria; however, the epithelia often develop dysplasia in a con...

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Veröffentlicht in:	Developmental cell 2021-01, Vol.56 (1), p.81-94.e10
Hauptverfasser:	Nagai, Hiroki, Tatara, Hiroshi, Tanaka-Furuhashi, Kyoko, Kurata, Shoichiro, Yano, Tamaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - metabolism Animals Animals, Genetically Modified Autophagy - drug effects Autophagy - genetics Cell Biology Cell Proliferation - genetics commensal bacteria Dachs Developmental Biology Dextran Sulfate - toxicity DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drosophila Drosophila - genetics Drosophila - immunology Drosophila - metabolism Drosophila - physiology Drosophila Proteins - genetics Drosophila Proteins - metabolism Enterocytes - metabolism Gene Knockdown Techniques Genome-Wide Association Study Hippo pathway Homeostasis host-microbe interaction Immunohistochemistry Inhibitor of Apoptosis Proteins - genetics Inhibitor of Apoptosis Proteins - metabolism intestinal barrier Intestinal Mucosa - cytology Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestines - cytology Intestines - drug effects Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Life Sciences & Biomedicine Muscle Proteins Myosins - genetics Myosins - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Reactive Oxygen Species - metabolism RefP/p62 regenerative responses ROS autophagy Science & Technology Signal Transduction - drug effects Signal Transduction - genetics Stem Cells - metabolism Trans-Activators - genetics Trans-Activators - metabolism Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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