Reinforcement of hydrogel scaffold using oxidized-guar gum incorporated with curcumin-loaded zein nanoparticles to improve biological performance
Newly, the use of biocompatible injectable hydrogel with appropriate features for application in the tissue engineering area as a perfect wound dressing has been more attracted. For this purpose, the curcumin loaded Zein nanoparticles/aldehyde-modified guar gum/silk fibroin (Cur-NPs/OGG/SF) hydrogel...
Gespeichert in:
| Veröffentlicht in: | International journal of biological macromolecules 2021-01, Vol.167, p.59-65 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 65 |
|---|---|
| container_issue | |
| container_start_page | 59 |
| container_title | International journal of biological macromolecules |
| container_volume | 167 |
| creator | Nezhad-Mokhtari, Parinaz Ghorbani, Marjan Abdyazdani, Nima |
| description | Newly, the use of biocompatible injectable hydrogel with appropriate features for application in the tissue engineering area as a perfect wound dressing has been more attracted. For this purpose, the curcumin loaded Zein nanoparticles/aldehyde-modified guar gum/silk fibroin (Cur-NPs/OGG/SF) hydrogel networks were successfully developed to increase the Cur bioavailability during the wound treatment procedure. Fabricated hydrogels were assessed for their morphological, thermal stability, degradation, and mechanical features. By varying the OGG/SF weight ratios, the physicochemical features of hydrogels without or with Cur-loaded Zein NPs were studied. The results showed that with enhancing the OGG content, the degradation behavior of hydrogels were improved. Besides, Cur-NPs/OGG/SF hydrogels increased the cell proliferation without any cytotoxic effect on mouse embryonic fibroblast (NIH-3T3) cells. The Cur-NPs/OGG/SF hydrogel exposed inhibition activity against Bacillus (15.26 ± 1.09 mm) and E. coli (11.54± 1.36 mm) bacteria. These achieved results recommended that the novel developed hydrogel could be suitable for wound healing application. |
| doi_str_mv | 10.1016/j.ijbiomac.2020.11.103 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1016_j_ijbiomac_2020_11_103</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0141813020350315</els_id><sourcerecordid>33212103</sourcerecordid><originalsourceid>FETCH-LOGICAL-c368t-575ed48b7f39b38b33b163193abf3abb7cf4c593ecf0ee9c23c4c3a2512dce5a3</originalsourceid><addsrcrecordid>eNqFkN1q3DAQhUVIabZpXyHoBbyRPGuvfZcS-hMIFEp7LeTRyJnFtoxkp03eom9che32NheD4OOcmaMjxJVWW610fX3Y8qHjMFrclqrMUGcOZ2Kjm31bKKXgXGyU3umi0aAuxLuUDpnWlW7eiguAUpdZvxF_vhNPPkSkkaZFBi8fnlwMPQ0yofU-DE6uiadeht_s-Jlc0a82yn4dJU8Y4hyiXcjJX7w8SFwjriNPxRCsy_A5L5eTncJs48I4UJJLkDzOMTySzPmH0DPaQc4Uc4jRTkjvxRtvh0Qf_r2X4ufnTz9uvxb3377c3X68LxDqZimqfUVu13R7D20HTQfQ6Rp0C7bzebo9-h1WLRB6RdRiCbhDsGWlS4dUWbgU9XEvxpBSJG_myKONT0Yr89KxOZhTx-alY6N15pCNV0fjvHYjuf-2U6lZcHMUUI7_yBRNQqb8NceRcDEu8Gs3_gID_pZh</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Reinforcement of hydrogel scaffold using oxidized-guar gum incorporated with curcumin-loaded zein nanoparticles to improve biological performance</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Nezhad-Mokhtari, Parinaz ; Ghorbani, Marjan ; Abdyazdani, Nima</creator><creatorcontrib>Nezhad-Mokhtari, Parinaz ; Ghorbani, Marjan ; Abdyazdani, Nima</creatorcontrib><description>Newly, the use of biocompatible injectable hydrogel with appropriate features for application in the tissue engineering area as a perfect wound dressing has been more attracted. For this purpose, the curcumin loaded Zein nanoparticles/aldehyde-modified guar gum/silk fibroin (Cur-NPs/OGG/SF) hydrogel networks were successfully developed to increase the Cur bioavailability during the wound treatment procedure. Fabricated hydrogels were assessed for their morphological, thermal stability, degradation, and mechanical features. By varying the OGG/SF weight ratios, the physicochemical features of hydrogels without or with Cur-loaded Zein NPs were studied. The results showed that with enhancing the OGG content, the degradation behavior of hydrogels were improved. Besides, Cur-NPs/OGG/SF hydrogels increased the cell proliferation without any cytotoxic effect on mouse embryonic fibroblast (NIH-3T3) cells. The Cur-NPs/OGG/SF hydrogel exposed inhibition activity against Bacillus (15.26 ± 1.09 mm) and E. coli (11.54± 1.36 mm) bacteria. These achieved results recommended that the novel developed hydrogel could be suitable for wound healing application.</description><identifier>ISSN: 0141-8130</identifier><identifier>EISSN: 1879-0003</identifier><identifier>DOI: 10.1016/j.ijbiomac.2020.11.103</identifier><identifier>PMID: 33212103</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Anti-Infective Agents - chemistry ; Anti-Infective Agents - pharmacology ; Bombyx ; Cell Line ; Cell Survival - drug effects ; Chemical Phenomena ; Curcumin - administration & dosage ; Fibroins - chemistry ; Galactans - chemistry ; Guar gum ; Hydrogels - chemistry ; Mannans - chemistry ; Mice ; Microbial Sensitivity Tests ; Nanoparticles - chemistry ; Nanoparticles - ultrastructure ; Oxidation-Reduction ; Plant Gums - chemistry ; Rheology ; Scaffold ; Spectrum Analysis ; Thermogravimetry ; Tissue Scaffolds - chemistry ; Zein - chemistry ; Zein nanoparticle</subject><ispartof>International journal of biological macromolecules, 2021-01, Vol.167, p.59-65</ispartof><rights>2020</rights><rights>Copyright © 2020. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-575ed48b7f39b38b33b163193abf3abb7cf4c593ecf0ee9c23c4c3a2512dce5a3</citedby><cites>FETCH-LOGICAL-c368t-575ed48b7f39b38b33b163193abf3abb7cf4c593ecf0ee9c23c4c3a2512dce5a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0141813020350315$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33212103$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nezhad-Mokhtari, Parinaz</creatorcontrib><creatorcontrib>Ghorbani, Marjan</creatorcontrib><creatorcontrib>Abdyazdani, Nima</creatorcontrib><title>Reinforcement of hydrogel scaffold using oxidized-guar gum incorporated with curcumin-loaded zein nanoparticles to improve biological performance</title><title>International journal of biological macromolecules</title><addtitle>Int J Biol Macromol</addtitle><description>Newly, the use of biocompatible injectable hydrogel with appropriate features for application in the tissue engineering area as a perfect wound dressing has been more attracted. For this purpose, the curcumin loaded Zein nanoparticles/aldehyde-modified guar gum/silk fibroin (Cur-NPs/OGG/SF) hydrogel networks were successfully developed to increase the Cur bioavailability during the wound treatment procedure. Fabricated hydrogels were assessed for their morphological, thermal stability, degradation, and mechanical features. By varying the OGG/SF weight ratios, the physicochemical features of hydrogels without or with Cur-loaded Zein NPs were studied. The results showed that with enhancing the OGG content, the degradation behavior of hydrogels were improved. Besides, Cur-NPs/OGG/SF hydrogels increased the cell proliferation without any cytotoxic effect on mouse embryonic fibroblast (NIH-3T3) cells. The Cur-NPs/OGG/SF hydrogel exposed inhibition activity against Bacillus (15.26 ± 1.09 mm) and E. coli (11.54± 1.36 mm) bacteria. These achieved results recommended that the novel developed hydrogel could be suitable for wound healing application.</description><subject>Animals</subject><subject>Anti-Infective Agents - chemistry</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Bombyx</subject><subject>Cell Line</subject><subject>Cell Survival - drug effects</subject><subject>Chemical Phenomena</subject><subject>Curcumin - administration & dosage</subject><subject>Fibroins - chemistry</subject><subject>Galactans - chemistry</subject><subject>Guar gum</subject><subject>Hydrogels - chemistry</subject><subject>Mannans - chemistry</subject><subject>Mice</subject><subject>Microbial Sensitivity Tests</subject><subject>Nanoparticles - chemistry</subject><subject>Nanoparticles - ultrastructure</subject><subject>Oxidation-Reduction</subject><subject>Plant Gums - chemistry</subject><subject>Rheology</subject><subject>Scaffold</subject><subject>Spectrum Analysis</subject><subject>Thermogravimetry</subject><subject>Tissue Scaffolds - chemistry</subject><subject>Zein - chemistry</subject><subject>Zein nanoparticle</subject><issn>0141-8130</issn><issn>1879-0003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkN1q3DAQhUVIabZpXyHoBbyRPGuvfZcS-hMIFEp7LeTRyJnFtoxkp03eom9che32NheD4OOcmaMjxJVWW610fX3Y8qHjMFrclqrMUGcOZ2Kjm31bKKXgXGyU3umi0aAuxLuUDpnWlW7eiguAUpdZvxF_vhNPPkSkkaZFBi8fnlwMPQ0yofU-DE6uiadeht_s-Jlc0a82yn4dJU8Y4hyiXcjJX7w8SFwjriNPxRCsy_A5L5eTncJs48I4UJJLkDzOMTySzPmH0DPaQc4Uc4jRTkjvxRtvh0Qf_r2X4ufnTz9uvxb3377c3X68LxDqZimqfUVu13R7D20HTQfQ6Rp0C7bzebo9-h1WLRB6RdRiCbhDsGWlS4dUWbgU9XEvxpBSJG_myKONT0Yr89KxOZhTx-alY6N15pCNV0fjvHYjuf-2U6lZcHMUUI7_yBRNQqb8NceRcDEu8Gs3_gID_pZh</recordid><startdate>20210115</startdate><enddate>20210115</enddate><creator>Nezhad-Mokhtari, Parinaz</creator><creator>Ghorbani, Marjan</creator><creator>Abdyazdani, Nima</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20210115</creationdate><title>Reinforcement of hydrogel scaffold using oxidized-guar gum incorporated with curcumin-loaded zein nanoparticles to improve biological performance</title><author>Nezhad-Mokhtari, Parinaz ; Ghorbani, Marjan ; Abdyazdani, Nima</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-575ed48b7f39b38b33b163193abf3abb7cf4c593ecf0ee9c23c4c3a2512dce5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Anti-Infective Agents - chemistry</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Bombyx</topic><topic>Cell Line</topic><topic>Cell Survival - drug effects</topic><topic>Chemical Phenomena</topic><topic>Curcumin - administration & dosage</topic><topic>Fibroins - chemistry</topic><topic>Galactans - chemistry</topic><topic>Guar gum</topic><topic>Hydrogels - chemistry</topic><topic>Mannans - chemistry</topic><topic>Mice</topic><topic>Microbial Sensitivity Tests</topic><topic>Nanoparticles - chemistry</topic><topic>Nanoparticles - ultrastructure</topic><topic>Oxidation-Reduction</topic><topic>Plant Gums - chemistry</topic><topic>Rheology</topic><topic>Scaffold</topic><topic>Spectrum Analysis</topic><topic>Thermogravimetry</topic><topic>Tissue Scaffolds - chemistry</topic><topic>Zein - chemistry</topic><topic>Zein nanoparticle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nezhad-Mokhtari, Parinaz</creatorcontrib><creatorcontrib>Ghorbani, Marjan</creatorcontrib><creatorcontrib>Abdyazdani, Nima</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>International journal of biological macromolecules</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nezhad-Mokhtari, Parinaz</au><au>Ghorbani, Marjan</au><au>Abdyazdani, Nima</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reinforcement of hydrogel scaffold using oxidized-guar gum incorporated with curcumin-loaded zein nanoparticles to improve biological performance</atitle><jtitle>International journal of biological macromolecules</jtitle><addtitle>Int J Biol Macromol</addtitle><date>2021-01-15</date><risdate>2021</risdate><volume>167</volume><spage>59</spage><epage>65</epage><pages>59-65</pages><issn>0141-8130</issn><eissn>1879-0003</eissn><abstract>Newly, the use of biocompatible injectable hydrogel with appropriate features for application in the tissue engineering area as a perfect wound dressing has been more attracted. For this purpose, the curcumin loaded Zein nanoparticles/aldehyde-modified guar gum/silk fibroin (Cur-NPs/OGG/SF) hydrogel networks were successfully developed to increase the Cur bioavailability during the wound treatment procedure. Fabricated hydrogels were assessed for their morphological, thermal stability, degradation, and mechanical features. By varying the OGG/SF weight ratios, the physicochemical features of hydrogels without or with Cur-loaded Zein NPs were studied. The results showed that with enhancing the OGG content, the degradation behavior of hydrogels were improved. Besides, Cur-NPs/OGG/SF hydrogels increased the cell proliferation without any cytotoxic effect on mouse embryonic fibroblast (NIH-3T3) cells. The Cur-NPs/OGG/SF hydrogel exposed inhibition activity against Bacillus (15.26 ± 1.09 mm) and E. coli (11.54± 1.36 mm) bacteria. These achieved results recommended that the novel developed hydrogel could be suitable for wound healing application.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>33212103</pmid><doi>10.1016/j.ijbiomac.2020.11.103</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0141-8130 |
| ispartof | International journal of biological macromolecules, 2021-01, Vol.167, p.59-65 |
| issn | 0141-8130 1879-0003 |
| language | eng |
| recordid | cdi_crossref_primary_10_1016_j_ijbiomac_2020_11_103 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Bombyx Cell Line Cell Survival - drug effects Chemical Phenomena Curcumin - administration & dosage Fibroins - chemistry Galactans - chemistry Guar gum Hydrogels - chemistry Mannans - chemistry Mice Microbial Sensitivity Tests Nanoparticles - chemistry Nanoparticles - ultrastructure Oxidation-Reduction Plant Gums - chemistry Rheology Scaffold Spectrum Analysis Thermogravimetry Tissue Scaffolds - chemistry Zein - chemistry Zein nanoparticle |
| title | Reinforcement of hydrogel scaffold using oxidized-guar gum incorporated with curcumin-loaded zein nanoparticles to improve biological performance |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-18T21%3A34%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Reinforcement%20of%20hydrogel%20scaffold%20using%20oxidized-guar%20gum%20incorporated%20with%20curcumin-loaded%20zein%20nanoparticles%20to%20improve%20biological%20performance&rft.jtitle=International%20journal%20of%20biological%20macromolecules&rft.au=Nezhad-Mokhtari,%20Parinaz&rft.date=2021-01-15&rft.volume=167&rft.spage=59&rft.epage=65&rft.pages=59-65&rft.issn=0141-8130&rft.eissn=1879-0003&rft_id=info:doi/10.1016/j.ijbiomac.2020.11.103&rft_dat=%3Cpubmed_cross%3E33212103%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/33212103&rft_els_id=S0141813020350315&rfr_iscdi=true |