Air pollution during infancy and lung function development into adolescence: The GINIplus/LISA birth cohorts study
•Infancy air pollution exposure affects lung function growth up to adolescence.•Airway size may be more affected than lung volume restriction.•Maternal age, asthma and breastfeeding duration may modify the adverse effects. Limited evidence exists on how air pollution exposure during infancy, i.e. th...
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| Veröffentlicht in: | Environment international 2021-01, Vol.146, p.106195, Article 106195 |
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| creator | Zhao, Qi Kress, Sara Markevych, Iana Berdel, Dietrich von Berg, Andrea Gappa, Monika Koletzko, Sibylle Bauer, Carl-Peter Schulz, Holger Standl, Marie Heinrich, Joachim Schikowski, Tamara |
| description | •Infancy air pollution exposure affects lung function growth up to adolescence.•Airway size may be more affected than lung volume restriction.•Maternal age, asthma and breastfeeding duration may modify the adverse effects.
Limited evidence exists on how air pollution exposure during infancy, i.e. the first year of life, may affect lung function development into adolescence.
To investigate the association between exposure to air pollution during the first-year of life and lung function development up to the age of 15 in Germany.
We investigated 915 children from the GINIplus and LISA birth cohorts from Munich (n = 181) and Wesel (n = 734), who had at least two spirometric measurements at ages 6, 10 and 15. Z-scores of forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were calculated. Annual average concentrations of nitrogen dioxide, particulate matter with diameters |
| doi_str_mv | 10.1016/j.envint.2020.106195 |
| format | Article |
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Limited evidence exists on how air pollution exposure during infancy, i.e. the first year of life, may affect lung function development into adolescence.
To investigate the association between exposure to air pollution during the first-year of life and lung function development up to the age of 15 in Germany.
We investigated 915 children from the GINIplus and LISA birth cohorts from Munich (n = 181) and Wesel (n = 734), who had at least two spirometric measurements at ages 6, 10 and 15. Z-scores of forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were calculated. Annual average concentrations of nitrogen dioxide, particulate matter with diameters <2.5, <10 and 2.5–10 µm (PM2.5/10/coarse), and PM2.5 absorbance at home addresses during the first-year of life, were estimated by land-use regression models. Associations between infancy exposure and lung function changes were fitted using multivariable linear mixed models with adjustment for potential confounders.
For per interquartile range increase in air pollutants during the first-year life, FEV1 z-scores declined annually by −0.012 (95% confidence interval (CI): −0.014, −0.009) for PM2.5 to −0.023 (95%CI: −0.028, −0.018) for PMcoarse. The declines in FVC were lower than FEV1 [−0.006 (95%CI: −0.008, −0.003) to −0.011 (95%CI: −0.019, −0.003)]. In Munich, the attenuations were only significant for FEV1. Effect estimates of infancy exposure for certain air pollutants were higher for groups with asthma, older maternal age, and breastfeeding <12 weeks than their counterparts.
Infancy exposure to higher air pollution may reduce lung function development up to adolescence, with airway size more affected than lung volume restriction. The potential modifying effects of maternal age, asthmatic status of children and breastfeeding warrant further exploration.</description><identifier>ISSN: 0160-4120</identifier><identifier>EISSN: 1873-6750</identifier><identifier>DOI: 10.1016/j.envint.2020.106195</identifier><identifier>PMID: 33099064</identifier><language>eng</language><publisher>OXFORD: Elsevier Ltd</publisher><subject>Adolescent ; Air Pollutants - analysis ; Air Pollution - adverse effects ; Air Pollution - analysis ; Child ; Children ; Environmental exposure ; Environmental Exposure - analysis ; Environmental Sciences ; Environmental Sciences & Ecology ; Forced Expiratory Volume ; Germany ; Humans ; Infant ; Life Sciences & Biomedicine ; Lung ; Particulate Matter - analysis ; Respiratory health ; Science & Technology</subject><ispartof>Environment international, 2021-01, Vol.146, p.106195, Article 106195</ispartof><rights>2020 The Author(s)</rights><rights>Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>15</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000604625200004</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c474t-579276902b0d8405fb24690ae179546dfd10e0d794962532dabe5b5d2fdc56da3</citedby><cites>FETCH-LOGICAL-c474t-579276902b0d8405fb24690ae179546dfd10e0d794962532dabe5b5d2fdc56da3</cites><orcidid>0000-0002-5214-0748 ; 0000-0002-9620-1629</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.envint.2020.106195$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,781,785,865,2103,2115,3551,27929,27930,39263,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33099064$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Qi</creatorcontrib><creatorcontrib>Kress, Sara</creatorcontrib><creatorcontrib>Markevych, Iana</creatorcontrib><creatorcontrib>Berdel, Dietrich</creatorcontrib><creatorcontrib>von Berg, Andrea</creatorcontrib><creatorcontrib>Gappa, Monika</creatorcontrib><creatorcontrib>Koletzko, Sibylle</creatorcontrib><creatorcontrib>Bauer, Carl-Peter</creatorcontrib><creatorcontrib>Schulz, Holger</creatorcontrib><creatorcontrib>Standl, Marie</creatorcontrib><creatorcontrib>Heinrich, Joachim</creatorcontrib><creatorcontrib>Schikowski, Tamara</creatorcontrib><title>Air pollution during infancy and lung function development into adolescence: The GINIplus/LISA birth cohorts study</title><title>Environment international</title><addtitle>ENVIRON INT</addtitle><addtitle>Environ Int</addtitle><description>•Infancy air pollution exposure affects lung function growth up to adolescence.•Airway size may be more affected than lung volume restriction.•Maternal age, asthma and breastfeeding duration may modify the adverse effects.
Limited evidence exists on how air pollution exposure during infancy, i.e. the first year of life, may affect lung function development into adolescence.
To investigate the association between exposure to air pollution during the first-year of life and lung function development up to the age of 15 in Germany.
We investigated 915 children from the GINIplus and LISA birth cohorts from Munich (n = 181) and Wesel (n = 734), who had at least two spirometric measurements at ages 6, 10 and 15. Z-scores of forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were calculated. Annual average concentrations of nitrogen dioxide, particulate matter with diameters <2.5, <10 and 2.5–10 µm (PM2.5/10/coarse), and PM2.5 absorbance at home addresses during the first-year of life, were estimated by land-use regression models. Associations between infancy exposure and lung function changes were fitted using multivariable linear mixed models with adjustment for potential confounders.
For per interquartile range increase in air pollutants during the first-year life, FEV1 z-scores declined annually by −0.012 (95% confidence interval (CI): −0.014, −0.009) for PM2.5 to −0.023 (95%CI: −0.028, −0.018) for PMcoarse. The declines in FVC were lower than FEV1 [−0.006 (95%CI: −0.008, −0.003) to −0.011 (95%CI: −0.019, −0.003)]. In Munich, the attenuations were only significant for FEV1. Effect estimates of infancy exposure for certain air pollutants were higher for groups with asthma, older maternal age, and breastfeeding <12 weeks than their counterparts.
Infancy exposure to higher air pollution may reduce lung function development up to adolescence, with airway size more affected than lung volume restriction. The potential modifying effects of maternal age, asthmatic status of children and breastfeeding warrant further exploration.</description><subject>Adolescent</subject><subject>Air Pollutants - analysis</subject><subject>Air Pollution - adverse effects</subject><subject>Air Pollution - analysis</subject><subject>Child</subject><subject>Children</subject><subject>Environmental exposure</subject><subject>Environmental Exposure - analysis</subject><subject>Environmental Sciences</subject><subject>Environmental Sciences & Ecology</subject><subject>Forced Expiratory Volume</subject><subject>Germany</subject><subject>Humans</subject><subject>Infant</subject><subject>Life Sciences & Biomedicine</subject><subject>Lung</subject><subject>Particulate Matter - analysis</subject><subject>Respiratory health</subject><subject>Science & Technology</subject><issn>0160-4120</issn><issn>1873-6750</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNqNkUGP0zAQhSMEYsvCP0DId9Tu2LGdhgNSVcESqYIDy9ly7MnWVWpXjtNV_z0OWXpEnDwefe9J815RvKewokDl3WGF_ux8WjFg00rSWrwoFnRdlUtZCXhZLDIGS04Z3BRvhuEAAIyvxevipiyhrkHyRRE3LpJT6PsxueCJHaPzj8T5TntzIdpb0o950Y3ezACesQ-nI_qUqRSItqHHwaA3-Ik87JHcN9-bUz8Od7vm54a0LqY9MWEfYhrIkEZ7eVu86nQ_4Lvn97b49fXLw_bbcvfjvtludkvDK56WoqpZJWtgLdg1B9G1jOevRlrVgkvbWQoItqp5LZkomdUtilZY1lkjpNXlbdHMvjbogzpFd9TxooJ26s8ixEelY3KmR4UdM1DJjrZScJs9AdcoAGjVtrW0PHvx2cvEMAwRu6sfBTXVoQ5qrkNNdai5jiz7MMtOY3tEexX9zT8D6xl4wjZ0g3FTjlcsFyaB5-tYnoBvXdJTCdsw-pSlH_9fmunPM4058bPDqJ4V1kU0KUfi_n3Kbx--vsY</recordid><startdate>202101</startdate><enddate>202101</enddate><creator>Zhao, Qi</creator><creator>Kress, Sara</creator><creator>Markevych, Iana</creator><creator>Berdel, Dietrich</creator><creator>von Berg, Andrea</creator><creator>Gappa, Monika</creator><creator>Koletzko, Sibylle</creator><creator>Bauer, Carl-Peter</creator><creator>Schulz, Holger</creator><creator>Standl, Marie</creator><creator>Heinrich, Joachim</creator><creator>Schikowski, Tamara</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-5214-0748</orcidid><orcidid>https://orcid.org/0000-0002-9620-1629</orcidid></search><sort><creationdate>202101</creationdate><title>Air pollution during infancy and lung function development into adolescence: The GINIplus/LISA birth cohorts study</title><author>Zhao, Qi ; Kress, Sara ; Markevych, Iana ; Berdel, Dietrich ; von Berg, Andrea ; Gappa, Monika ; Koletzko, Sibylle ; Bauer, Carl-Peter ; Schulz, Holger ; Standl, Marie ; Heinrich, Joachim ; Schikowski, Tamara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-579276902b0d8405fb24690ae179546dfd10e0d794962532dabe5b5d2fdc56da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Air Pollutants - analysis</topic><topic>Air Pollution - adverse effects</topic><topic>Air Pollution - analysis</topic><topic>Child</topic><topic>Children</topic><topic>Environmental exposure</topic><topic>Environmental Exposure - analysis</topic><topic>Environmental Sciences</topic><topic>Environmental Sciences & Ecology</topic><topic>Forced Expiratory Volume</topic><topic>Germany</topic><topic>Humans</topic><topic>Infant</topic><topic>Life Sciences & Biomedicine</topic><topic>Lung</topic><topic>Particulate Matter - analysis</topic><topic>Respiratory health</topic><topic>Science & Technology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Qi</creatorcontrib><creatorcontrib>Kress, Sara</creatorcontrib><creatorcontrib>Markevych, Iana</creatorcontrib><creatorcontrib>Berdel, Dietrich</creatorcontrib><creatorcontrib>von Berg, Andrea</creatorcontrib><creatorcontrib>Gappa, Monika</creatorcontrib><creatorcontrib>Koletzko, Sibylle</creatorcontrib><creatorcontrib>Bauer, Carl-Peter</creatorcontrib><creatorcontrib>Schulz, Holger</creatorcontrib><creatorcontrib>Standl, Marie</creatorcontrib><creatorcontrib>Heinrich, Joachim</creatorcontrib><creatorcontrib>Schikowski, Tamara</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Environment international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Qi</au><au>Kress, Sara</au><au>Markevych, Iana</au><au>Berdel, Dietrich</au><au>von Berg, Andrea</au><au>Gappa, Monika</au><au>Koletzko, Sibylle</au><au>Bauer, Carl-Peter</au><au>Schulz, Holger</au><au>Standl, Marie</au><au>Heinrich, Joachim</au><au>Schikowski, Tamara</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Air pollution during infancy and lung function development into adolescence: The GINIplus/LISA birth cohorts study</atitle><jtitle>Environment international</jtitle><stitle>ENVIRON INT</stitle><addtitle>Environ Int</addtitle><date>2021-01</date><risdate>2021</risdate><volume>146</volume><spage>106195</spage><pages>106195-</pages><artnum>106195</artnum><issn>0160-4120</issn><eissn>1873-6750</eissn><abstract>•Infancy air pollution exposure affects lung function growth up to adolescence.•Airway size may be more affected than lung volume restriction.•Maternal age, asthma and breastfeeding duration may modify the adverse effects.
Limited evidence exists on how air pollution exposure during infancy, i.e. the first year of life, may affect lung function development into adolescence.
To investigate the association between exposure to air pollution during the first-year of life and lung function development up to the age of 15 in Germany.
We investigated 915 children from the GINIplus and LISA birth cohorts from Munich (n = 181) and Wesel (n = 734), who had at least two spirometric measurements at ages 6, 10 and 15. Z-scores of forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were calculated. Annual average concentrations of nitrogen dioxide, particulate matter with diameters <2.5, <10 and 2.5–10 µm (PM2.5/10/coarse), and PM2.5 absorbance at home addresses during the first-year of life, were estimated by land-use regression models. Associations between infancy exposure and lung function changes were fitted using multivariable linear mixed models with adjustment for potential confounders.
For per interquartile range increase in air pollutants during the first-year life, FEV1 z-scores declined annually by −0.012 (95% confidence interval (CI): −0.014, −0.009) for PM2.5 to −0.023 (95%CI: −0.028, −0.018) for PMcoarse. The declines in FVC were lower than FEV1 [−0.006 (95%CI: −0.008, −0.003) to −0.011 (95%CI: −0.019, −0.003)]. In Munich, the attenuations were only significant for FEV1. Effect estimates of infancy exposure for certain air pollutants were higher for groups with asthma, older maternal age, and breastfeeding <12 weeks than their counterparts.
Infancy exposure to higher air pollution may reduce lung function development up to adolescence, with airway size more affected than lung volume restriction. The potential modifying effects of maternal age, asthmatic status of children and breastfeeding warrant further exploration.</abstract><cop>OXFORD</cop><pub>Elsevier Ltd</pub><pmid>33099064</pmid><doi>10.1016/j.envint.2020.106195</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-5214-0748</orcidid><orcidid>https://orcid.org/0000-0002-9620-1629</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Air Pollutants - analysis Air Pollution - adverse effects Air Pollution - analysis Child Children Environmental exposure Environmental Exposure - analysis Environmental Sciences Environmental Sciences & Ecology Forced Expiratory Volume Germany Humans Infant Life Sciences & Biomedicine Lung Particulate Matter - analysis Respiratory health Science & Technology |
| title | Air pollution during infancy and lung function development into adolescence: The GINIplus/LISA birth cohorts study |
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