Potential natural inhibitors of xanthine oxidase and HMG-CoA reductase in cholesterol regulation: in silico analysis

Background Hypercholesterolemia has posed a serious threat of heart diseases and stroke worldwide. Xanthine oxidase (XO), the rate-limiting enzyme in uric acid biosynthesis, is regarded as the root of reactive oxygen species (ROS) that generate atherosclerosis and cholesterol crystals. beta-Hydroxy...

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Veröffentlicht in:	BMC complementary and alternative medicine 2021-01, Vol.21 (1), p.1-11, Article 1
Hauptverfasser:	Marahatha, Rishab, Basnet, Saroj, Bhattarai, Bibek Raj, Budhathoki, Prakriti, Aryal, Babita, Adhikari, Bikash, Lamichhane, Ganesh, Poudel, Darbin Kumar, Parajuli, Niranjan
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative medicine Analysis Anticholesteremic agents Arteriosclerosis Atherosclerosis Bile Biological products Biosynthesis Cardiovascular diseases Cholesterol Coenzyme A Computer applications Constraining Coronary artery disease Crystal structure Crystals Drug development Drugs Enzyme inhibition Enzymes Gingerol Gold Heart diseases Hydroxymethylglutaryl-CoA reductase Hypercholesterolemia Inhibitors Integrative & Complementary Medicine Iron compounds Life Sciences & Biomedicine Ligands Literature reviews Metabolites Molecular docking Natural products Oxidases Oxidative stress Physical fitness Physiological aspects Plant metabolites Proteins Reactive oxygen species Reductases Science & Technology Secondary metabolites Software Statins Stroke (Disease) Thiols Toxicity Uric acid Xanthine oxidase
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