The Intestinal Efflux Transporter Inhibition Activity of Xanthones from Mangosteen Pericarp: An In Silico, In Vitro and Ex Vivo Approach

The capacity of alpha-mangostin (alpha-MG) and beta-mangostin (beta-MG) from mangosteen pericarp on P-glycoprotein (Pgp) in silico, in vitro, and ex vivo was investigated in this study. Screening with the ADMET Predictor (TM) program predicted the two compounds to be both a Pgp inhibitor and Pgp sub...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2020-12, Vol.25 (24), p.5877, Article 5877
Hauptverfasser:	Dechwongya, Panudda, Limpisood, Songpol, Boonnak, Nawong, Mangmool, Supachoke, Takeda-Morishita, Mariko, Kulsirirat, Thitianan, Rukthong, Pattarawit, Sathirakul, Korbtham
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorptivity Adenosine triphosphatase bidirectional transport Bioavailability Biochemistry & Molecular Biology caco-2 cell Chemistry Chemistry, Multidisciplinary Cytotoxicity Efflux Experiments Gene expression Glycoproteins Ileum Inhibitors Intestine Life Sciences & Biomedicine mangosteen pericarp MDR1 expression MDR1 protein Multidrug resistance P-Glycoprotein Physical Sciences Science & Technology Substrate inhibition Substrates xanthones
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