Lactate Metabolism in Breast Cancer Microenvironment: Contribution Focused on Associated Adipose Tissue and Obesity

Metabolic reprogramming that favors high glycolytic flux with lactate production in normoxia is among cancer hallmarks. Lactate is an essential oncometabolite regulating cellular redox homeostasis, energy substrate partitioning, and intracellular signaling. Moreover, malignant phenotype's chief...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of molecular sciences 2020-12, Vol.21 (24), p.9676, Article 9676
Hauptverfasser:	Kalezic, Andjelika, Udicki, Mirjana, Srdic Galic, Biljana, Aleksic, Marija, Korac, Aleksandra, Jankovic, Aleksandra, Korac, Bato
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipose tissue Adipose Tissue - metabolism Adult Biochemistry & Molecular Biology Biopsy Biosynthesis Body fat Body weight Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology cancer-associated adipose tissue Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - pathology Chemistry Chemistry, Multidisciplinary Cooperation Crosstalk Dehydrogenases Energy resources Enzymes Female Follow-Up Studies Gene expression Glycolysis Homeostasis Humans Intracellular signalling Invasiveness Isoenzymes Isoforms L-Lactate dehydrogenase L-Lactate Dehydrogenase - metabolism lactate Lactate dehydrogenase Lactic acid Lactic Acid - metabolism Life Sciences & Biomedicine Localization Metabolism Muscles Neoplasm Invasiveness Obesity Obesity - metabolism Obesity - pathology Overweight Oxidation Phenotypes Physical Sciences premenopausal breast cancer Prognosis Protein expression Proteins Receptor, ErbB-2 - metabolism Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Science & Technology Tumor Microenvironment Tumors Womens health
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!