Chemical Synthesis of an Erythropoietin Glycoform Having a Triantennary N‑Glycan: Significant Change of Biological Activity of Glycoprotein by Addition of a Small Molecular Weight Trisaccharide

The glycosylation of proteins contributes to the modulation of the structure and biological activity of glycoproteins. Asparagine-linked glycans (N-glycans) of glycoproteins naturally exhibit diverse antennary patterns, such as bi-, tri-, and tetra-antennary forms. However, there are no chemical or...

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Veröffentlicht in:	Journal of the American Chemical Society 2020-12, Vol.142 (49), p.20671-20679
Hauptverfasser:	Maki, Yuta, Okamoto, Ryo, Izumi, Masayuki, Kajihara, Yasuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Chemistry Chemistry, Multidisciplinary Erythropoietin - chemical synthesis Erythropoietin - chemistry Erythropoietin - pharmacology Glycosylation Hematopoiesis - drug effects Mice Mice, Inbred BALB C Molecular Weight Physical Sciences Polysaccharides - chemistry Recombinant Proteins - pharmacology Science & Technology Trisaccharides - chemistry
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