A single-arm, phase 2 study of adjuvant chemotherapy with oral tegafur-uracil for pathologically lymphovascular invasion positive stage IA non-small cell lung cancer: LOGIK0602 study

BackgroundLymphovascular invasion (LVI), which includes vascular or lymphatic invasions, is a representative prognostic factor even in patients with resected stage IA non-small cell lung cancer (NSCLC). Because tegafur-uracil is effective on cancers with LVI, we conducted a multi-center single-arm p...

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Veröffentlicht in:	BMC cancer 2020-12, Vol.20 (1), p.1192-8, Article 1192
Hauptverfasser:	Tsuchiya, Tomoshi, Kamohara, Ryotaro, Muraoka, Masashi, Nagayasu, Takeshi, Saeki, Sho, Takenoyama, Mitsuhiro, Suzuki, Makoto, Inada, Kazuo, Tokunaga, Shoji, Hayashi, Tomayoshi, Urabe, Shogo, Koga, Takaomi, Akamine, Shinji, Sugio, Kenji
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant chemotherapy Adjuvants, Pharmaceutic Aged Angiogenesis Anorexia Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Blood Vessels - pathology Cancer therapies Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - surgery Chemotherapy Chemotherapy, Adjuvant - adverse effects Combined Modality Therapy Compliance Creatinine Development and progression Disease-Free Survival Drug dosages Drug therapy Female Gastrointestinal Diseases - chemically induced Humans Kaplan-Meier Estimate Life Sciences & Biomedicine Lung cancer Lung cancer, Non-small cell Lung Neoplasms - drug therapy Lung Neoplasms - pathology Lung Neoplasms - surgery Lymphatic metastasis Lymphatic Vessels - pathology Lymphovascular invasion Male Medical prognosis Middle Aged Neoplasm Invasiveness Neutropenia - chemically induced Non-small cell lung cancer Non-small cell lung carcinoma Oncology Patient Compliance Patient outcomes Patients Phase II study Pneumonectomy Prodrugs - administration & dosage Prodrugs - adverse effects Prospective Studies Science & Technology Small cell lung carcinoma Survival analysis Targeted therapy Tegafur Tegafur - administration & dosage Tegafur - adverse effects Tegafur-uracil Uracil Uracil - administration & dosage Uracil - adverse effects Vascular endothelial growth factor
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