How external perturbations affect the chemoselectivity of substrate activation by cytochrome P450 OleTJE

Cytochrome P450 enzymes are versatile biocatalysts found in most forms of life. Generally, the cytochrome P450s react with dioxygen and hence are haem-based mono-oxygenases; however, in specific isozymes, H2O2 rather than O-2 is used and these P450s act as peroxygenases. The P450 OleT(JE) is a perox...

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Veröffentlicht in:	Physical chemistry chemical physics : PCCP 2020-12, Vol.22 (46), p.27178-27190
Hauptverfasser:	Chowdhury, Ahmed Shahria, Ali, Hafiz Saqib, Faponle, Abayomi S., de Visser, Sam P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cartesian coordinates Chemistry Chemistry, Physical Cytochrome Cytochromes P450 Decarboxylation Density functional theory Desaturation Electric fields Environmental effects Fatty acids Histidine Hydrogen peroxide Hydroxylation Physical Sciences Physics Physics, Atomic, Molecular & Chemical Quantum mechanics Reaction mechanisms Residues Science & Technology Substrates
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