Protein-avoidant ionic liquid (PAIL)-coated nanoparticles to increase bloodstream circulation and drive biodistribution

The rapid clearance of intravenously administered nanoparticles (NPs) from the bloodstream is a major unsolved problem in nanomedicine. Here, we describe the first use of biocompatible protein-avoidant ionic liquids (PAILs) as NP surface modifiers to reduce opsonization. An ionic liquid choline hexe...

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Veröffentlicht in:	Science advances 2020-11, Vol.6 (48)
Hauptverfasser:	Hamadani, Christine M, Goetz, Morgan J, Mitragotri, Samir, Tanner, Eden E L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Choline Drug Carriers Engineering Health and Medicine Ionic Liquids Lactic Acid Materials Science Mice Nanoparticles Particle Size Polyglycolic Acid Polylactic Acid-Polyglycolic Acid Copolymer SciAdv r-articles Tissue Distribution
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