Synthesis and biological evaluation of imidazoline derivatives as potential CNS and CVS agents

[Display omitted] A series of substituted imidazoline derivatives were synthesized and characterized. Compounds were tested in-vivo for their antihypertensive, analgesic, antiaggressive, depressant, antidepressant, and ALD50 activities. The compounds 3a, 3c, 4c, 5a, and 6c showed cardiovascular as w...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2020-12, Vol.30 (23), p.127595-127595, Article 127595
Hauptverfasser:	Malhotra, Vineet, Vats, Monika, Nath, Rajendra, Mehta, Simpi, Kumar, Rakesh, Bhalla, Manish, Sinha, J.N., Shanker, K., Pathak, Seeema R.
Format:	Artikel
Sprache:	eng
Schlagworte:	ALD50 Chemistry Chemistry, Medicinal Chemistry, Organic CNS, analgesics, antiaggressive, depressants -antidepressants CO, NE, hypotensive Imidazoline, oxazolone Life Sciences & Biomedicine Morpholine Pharmacology & Pharmacy Physical Sciences Science & Technology
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