The Dark Side of Actin: Cardiac actin variants highlight the role of allostery in disease development

Mutations in the α-cardiac actin ACTC1 gene cause dilated or hypertrophic cardiomyopathy. These diseases are the result of changes in protein interactions between ACTC protein and force-generating β-myosin or the calcium-dependent cardiac-tropomyosin (cTm) and cardiac troponin (cTn) regulatory compl...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Archives of biochemistry and biophysics 2020-11, Vol.695, p.108624, Article 108624
Hauptverfasser:	Teng, Grace Zi, Dawson, John F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actins - chemistry Actins - genetics Actins - metabolism Allosteric Regulation Allostery Altered force pathway Amino Acid Substitution Animals Biochemistry & Molecular Biology Biophysics Calcium sensitivity pathway Cardiomyopathies Cardiomyopathy Humans Life Sciences & Biomedicine Mutation, Missense Science & Technology Sf9 Cells Spodoptera Troponin - chemistry Troponin - genetics Troponin - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!