Acute Stress-Induced Coagulation Activation in Patients With Remitted Major Depression Versus Healthy Controls and the Role of Stress-Specific Coping

Abstract Background Depressed patients have an increased risk of myocardial infarction, for which acute stress is a frequent trigger. Prothrombotic changes could be one involved mechanism that can be modulated by psychological coping. Purpose We examined the effects of remitted major depression and...

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Veröffentlicht in:Annals of behavioral medicine 2020-08, Vol.54 (8), p.611-618
Hauptverfasser: von Känel, Roland, Merz, Franziska, Pfister, Hildegard, Brückl, Tanja, Zimmermann, Petra, Uhr, Manfred, Holsboer, Florian, Höhne, Nina, Ising, Marcus
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container_end_page 618
container_issue 8
container_start_page 611
container_title Annals of behavioral medicine
container_volume 54
creator von Känel, Roland
Merz, Franziska
Pfister, Hildegard
Brückl, Tanja
Zimmermann, Petra
Uhr, Manfred
Holsboer, Florian
Höhne, Nina
Ising, Marcus
description Abstract Background Depressed patients have an increased risk of myocardial infarction, for which acute stress is a frequent trigger. Prothrombotic changes could be one involved mechanism that can be modulated by psychological coping. Purpose We examined the effects of remitted major depression and situation-specific coping strategies on stress-induced coagulation activation. Methods Forty patients with remitted depression and 23 healthy controls underwent the Trier Social Stress Test, rating applied coping strategies thereafter. Blood was sampled at baseline and 15 and 45 min poststress to measure fibrinogen, von Willebrand factor (VWF) and D-dimer. Coagulation activation over time was quantified as area under the curve (AUC) with respect to baseline activity. Standardized z-scores of individual coagulation AUC measures were added up to a prothrombotic index. Results Stress provoked significant VWF (p = .024) and D-dimer (p = .002) responses. Remitted depressed patients used positive distraction coping more frequently than controls did (p = .030). Coagulation AUC measures were similar in both groups. In all participants, higher positive coping total (p = 0.009), driven by devaluation/defense (p = .022) and distraction (p = .004) coping, was associated with a lower prothrombotic index. In controls, but not in remitted depressed patients, higher positive coping total (p = .008), driven by higher devaluation/defense (p = .010) and distraction (p = .023) coping, was associated with lower VWF AUC. Conclusions Despite the use of favorable coping strategies in a specific stress situation, remitted depressed patients may benefit less from a positive effect of positive situational coping on coagulation activation than controls. Such a mechanism could partially explain the increased risk of myocardial infarction in depressed individuals. Adaptive coping strategies with an acute stress task were associated with lower stress-induced acceleration of blood clotting, but this heart-protective effect seemed to be weaker in patients with remitted depression than in healthy persons
doi_str_mv 10.1093/abm/kaaa001
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Prothrombotic changes could be one involved mechanism that can be modulated by psychological coping. Purpose We examined the effects of remitted major depression and situation-specific coping strategies on stress-induced coagulation activation. Methods Forty patients with remitted depression and 23 healthy controls underwent the Trier Social Stress Test, rating applied coping strategies thereafter. Blood was sampled at baseline and 15 and 45 min poststress to measure fibrinogen, von Willebrand factor (VWF) and D-dimer. Coagulation activation over time was quantified as area under the curve (AUC) with respect to baseline activity. Standardized z-scores of individual coagulation AUC measures were added up to a prothrombotic index. Results Stress provoked significant VWF (p = .024) and D-dimer (p = .002) responses. Remitted depressed patients used positive distraction coping more frequently than controls did (p = .030). Coagulation AUC measures were similar in both groups. In all participants, higher positive coping total (p = 0.009), driven by devaluation/defense (p = .022) and distraction (p = .004) coping, was associated with a lower prothrombotic index. In controls, but not in remitted depressed patients, higher positive coping total (p = .008), driven by higher devaluation/defense (p = .010) and distraction (p = .023) coping, was associated with lower VWF AUC. Conclusions Despite the use of favorable coping strategies in a specific stress situation, remitted depressed patients may benefit less from a positive effect of positive situational coping on coagulation activation than controls. Such a mechanism could partially explain the increased risk of myocardial infarction in depressed individuals. Adaptive coping strategies with an acute stress task were associated with lower stress-induced acceleration of blood clotting, but this heart-protective effect seemed to be weaker in patients with remitted depression than in healthy persons</description><identifier>ISSN: 0883-6612</identifier><identifier>EISSN: 1532-4796</identifier><identifier>DOI: 10.1093/abm/kaaa001</identifier><identifier>PMID: 32044917</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Antidepressants ; Coping ; Health behavior ; Health psychology ; Heart attacks ; Mental depression ; Psychology ; Psychology, Multidisciplinary ; Social Sciences</subject><ispartof>Annals of behavioral medicine, 2020-08, Vol.54 (8), p.611-618</ispartof><rights>Society of Behavioral Medicine 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. 2020</rights><rights>Society of Behavioral Medicine 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>4</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000592740600008</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c402t-d24da7ef34da435ab48bbdc9b18cb10f73d395b0aa9b2350a27131c8ad2ce6fe3</citedby><cites>FETCH-LOGICAL-c402t-d24da7ef34da435ab48bbdc9b18cb10f73d395b0aa9b2350a27131c8ad2ce6fe3</cites><orcidid>0000-0002-8929-5129</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,1586,27931,27932,28256</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32044917$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>von Känel, Roland</creatorcontrib><creatorcontrib>Merz, Franziska</creatorcontrib><creatorcontrib>Pfister, Hildegard</creatorcontrib><creatorcontrib>Brückl, Tanja</creatorcontrib><creatorcontrib>Zimmermann, Petra</creatorcontrib><creatorcontrib>Uhr, Manfred</creatorcontrib><creatorcontrib>Holsboer, Florian</creatorcontrib><creatorcontrib>Höhne, Nina</creatorcontrib><creatorcontrib>Ising, Marcus</creatorcontrib><title>Acute Stress-Induced Coagulation Activation in Patients With Remitted Major Depression Versus Healthy Controls and the Role of Stress-Specific Coping</title><title>Annals of behavioral medicine</title><addtitle>ANN BEHAV MED</addtitle><addtitle>Ann Behav Med</addtitle><description>Abstract Background Depressed patients have an increased risk of myocardial infarction, for which acute stress is a frequent trigger. Prothrombotic changes could be one involved mechanism that can be modulated by psychological coping. Purpose We examined the effects of remitted major depression and situation-specific coping strategies on stress-induced coagulation activation. Methods Forty patients with remitted depression and 23 healthy controls underwent the Trier Social Stress Test, rating applied coping strategies thereafter. Blood was sampled at baseline and 15 and 45 min poststress to measure fibrinogen, von Willebrand factor (VWF) and D-dimer. Coagulation activation over time was quantified as area under the curve (AUC) with respect to baseline activity. Standardized z-scores of individual coagulation AUC measures were added up to a prothrombotic index. Results Stress provoked significant VWF (p = .024) and D-dimer (p = .002) responses. Remitted depressed patients used positive distraction coping more frequently than controls did (p = .030). Coagulation AUC measures were similar in both groups. In all participants, higher positive coping total (p = 0.009), driven by devaluation/defense (p = .022) and distraction (p = .004) coping, was associated with a lower prothrombotic index. In controls, but not in remitted depressed patients, higher positive coping total (p = .008), driven by higher devaluation/defense (p = .010) and distraction (p = .023) coping, was associated with lower VWF AUC. Conclusions Despite the use of favorable coping strategies in a specific stress situation, remitted depressed patients may benefit less from a positive effect of positive situational coping on coagulation activation than controls. Such a mechanism could partially explain the increased risk of myocardial infarction in depressed individuals. Adaptive coping strategies with an acute stress task were associated with lower stress-induced acceleration of blood clotting, but this heart-protective effect seemed to be weaker in patients with remitted depression than in healthy persons</description><subject>Antidepressants</subject><subject>Coping</subject><subject>Health behavior</subject><subject>Health psychology</subject><subject>Heart attacks</subject><subject>Mental depression</subject><subject>Psychology</subject><subject>Psychology, Multidisciplinary</subject><subject>Social Sciences</subject><issn>0883-6612</issn><issn>1532-4796</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ARHDP</sourceid><recordid>eNqNkUuLFDEUhYMoTju6ci8BQQQpJ696LZvyMQMjyoyPZZGkbk2nrUrKPJT5If5f03bPCC7ETe5ZfOfkcg9Cjyl5SUnLT6SaT75KKQmhd9CKlpwVom6ru2hFmoYXVUXZEXoQwpYQwgWt7qMjzogQLa1X6Odapwj4MnoIoTizQ9Iw4M7JqzTJaJzFax3N9700Fn_ICmwM-IuJG3wBs4kxG97JrfP4FSy7mB36GXxIAZ-CnOLmOgfa6N0UsLQDjhvAF24C7Mabjy8X0GY0OoOLsVcP0b1RTgEeHeYx-vTm9cfutDh___asW58XWhAWi4GJQdYw8jwEL6USjVKDbhVttKJkrPnA21IRKVvFeEkkqymnupED01CNwI_R833u4t23BCH2swkapklacCn02cTLuiFNmdGnf6Fbl7zN2_VMlIzmp6oz9WJPae9C8DD2izez9Nc9Jf2urT631R_ayvSTQ2ZSMwy37E09f-J-gHJj0Pn0Gm6x3GfZslqQKivSZLr5f7oz8XepnUs2ZuuzvdWl5Z8r_wLC58DJ</recordid><startdate>20200808</startdate><enddate>20200808</enddate><creator>von Känel, Roland</creator><creator>Merz, Franziska</creator><creator>Pfister, Hildegard</creator><creator>Brückl, Tanja</creator><creator>Zimmermann, Petra</creator><creator>Uhr, Manfred</creator><creator>Holsboer, Florian</creator><creator>Höhne, Nina</creator><creator>Ising, Marcus</creator><general>Oxford University Press</general><general>Oxford Univ Press</general><scope>17B</scope><scope>ARHDP</scope><scope>BLEPL</scope><scope>DVR</scope><scope>EGQ</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8929-5129</orcidid></search><sort><creationdate>20200808</creationdate><title>Acute Stress-Induced Coagulation Activation in Patients With Remitted Major Depression Versus Healthy Controls and the Role of Stress-Specific Coping</title><author>von Känel, Roland ; Merz, Franziska ; Pfister, Hildegard ; Brückl, Tanja ; Zimmermann, Petra ; Uhr, Manfred ; Holsboer, Florian ; Höhne, Nina ; Ising, Marcus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-d24da7ef34da435ab48bbdc9b18cb10f73d395b0aa9b2350a27131c8ad2ce6fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antidepressants</topic><topic>Coping</topic><topic>Health behavior</topic><topic>Health psychology</topic><topic>Heart attacks</topic><topic>Mental depression</topic><topic>Psychology</topic><topic>Psychology, Multidisciplinary</topic><topic>Social Sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>von Känel, Roland</creatorcontrib><creatorcontrib>Merz, Franziska</creatorcontrib><creatorcontrib>Pfister, Hildegard</creatorcontrib><creatorcontrib>Brückl, Tanja</creatorcontrib><creatorcontrib>Zimmermann, Petra</creatorcontrib><creatorcontrib>Uhr, Manfred</creatorcontrib><creatorcontrib>Holsboer, Florian</creatorcontrib><creatorcontrib>Höhne, Nina</creatorcontrib><creatorcontrib>Ising, Marcus</creatorcontrib><collection>Web of Knowledge</collection><collection>Web of Science - Social Sciences Citation Index – 2020</collection><collection>Web of Science Core Collection</collection><collection>Social Sciences Citation Index</collection><collection>Web of Science Primary (SCIE, SSCI &amp; AHCI)</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of behavioral medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>von Känel, Roland</au><au>Merz, Franziska</au><au>Pfister, Hildegard</au><au>Brückl, Tanja</au><au>Zimmermann, Petra</au><au>Uhr, Manfred</au><au>Holsboer, Florian</au><au>Höhne, Nina</au><au>Ising, Marcus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute Stress-Induced Coagulation Activation in Patients With Remitted Major Depression Versus Healthy Controls and the Role of Stress-Specific Coping</atitle><jtitle>Annals of behavioral medicine</jtitle><stitle>ANN BEHAV MED</stitle><addtitle>Ann Behav Med</addtitle><date>2020-08-08</date><risdate>2020</risdate><volume>54</volume><issue>8</issue><spage>611</spage><epage>618</epage><pages>611-618</pages><issn>0883-6612</issn><eissn>1532-4796</eissn><abstract>Abstract Background Depressed patients have an increased risk of myocardial infarction, for which acute stress is a frequent trigger. Prothrombotic changes could be one involved mechanism that can be modulated by psychological coping. Purpose We examined the effects of remitted major depression and situation-specific coping strategies on stress-induced coagulation activation. Methods Forty patients with remitted depression and 23 healthy controls underwent the Trier Social Stress Test, rating applied coping strategies thereafter. Blood was sampled at baseline and 15 and 45 min poststress to measure fibrinogen, von Willebrand factor (VWF) and D-dimer. Coagulation activation over time was quantified as area under the curve (AUC) with respect to baseline activity. Standardized z-scores of individual coagulation AUC measures were added up to a prothrombotic index. Results Stress provoked significant VWF (p = .024) and D-dimer (p = .002) responses. Remitted depressed patients used positive distraction coping more frequently than controls did (p = .030). Coagulation AUC measures were similar in both groups. In all participants, higher positive coping total (p = 0.009), driven by devaluation/defense (p = .022) and distraction (p = .004) coping, was associated with a lower prothrombotic index. In controls, but not in remitted depressed patients, higher positive coping total (p = .008), driven by higher devaluation/defense (p = .010) and distraction (p = .023) coping, was associated with lower VWF AUC. Conclusions Despite the use of favorable coping strategies in a specific stress situation, remitted depressed patients may benefit less from a positive effect of positive situational coping on coagulation activation than controls. Such a mechanism could partially explain the increased risk of myocardial infarction in depressed individuals. Adaptive coping strategies with an acute stress task were associated with lower stress-induced acceleration of blood clotting, but this heart-protective effect seemed to be weaker in patients with remitted depression than in healthy persons</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>32044917</pmid><doi>10.1093/abm/kaaa001</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8929-5129</orcidid></addata></record>
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subjects Antidepressants
Coping
Health behavior
Health psychology
Heart attacks
Mental depression
Psychology
Psychology, Multidisciplinary
Social Sciences
title Acute Stress-Induced Coagulation Activation in Patients With Remitted Major Depression Versus Healthy Controls and the Role of Stress-Specific Coping
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