Aldose reductase and protein tyrosine phosphatase 1B inhibitors as a promising therapeutic approach for diabetes mellitus

Diabetes mellitus is a metabolic disease characterized by high blood glucose levels and usually associated with several chronic pathologies. Aldose reductase and protein tyrosine phosphatase 1B enzymes have identified as two novel molecular targets associated with the onset and progression of type I...

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Veröffentlicht in:	European journal of medicinal chemistry 2020-12, Vol.207, p.112742-112742, Article 112742
Hauptverfasser:	Kousaxidis, Antonios, Petrou, Anthi, Lavrentaki, Vasiliki, Fesatidou, Maria, Nicolaou, Ioannis, Geronikaki, Athina
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde Reductase - antagonists & inhibitors Aldose reductase Animals Chemistry, Medicinal Diabetes mellitus Diabetes Mellitus - drug therapy Diabetes Mellitus - metabolism Diabetic complications Dual inhibitors Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Humans Insulin resistance Life Sciences & Biomedicine Molecular Targeted Therapy - methods Pharmacology & Pharmacy Protein tyrosine phosphatase 1B Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors Science & Technology Selectivity
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