Associations between the concentrations of CD68, TGF-beta 1, renal injury index and prognosis in glomerular diseases

The present study aimed to investigate the association between the concentrations of CD68, TGF-beta 1, renal injury index and prognosis in glomerular diseases. Altogether 218 patients with glomerular diseases admitted to Weifang People's Hospital from January, 2014 to March, 2017 were used as the study group. A total of 100 healthy individuals who visited Weifang People's Hospital for a physical examination during the same time period were used as the control group. The levels of CD68 in peripheral blood obtained from the 2 groups of subjects were detected by flow cytometry, and the expression of TGF-beta 1 in serum was detected by enzyme-linked immunosorbent assay (ELISA). The concentrations of CD68 and TGF-beta 1 between the 2 groups were compared. The correlation between the concentrations of CD68, TGF-beta 1 and renal injury indexes in the study group was analyzed, as well as prognostic significance. The diagnostic value of CD68 and TGF-beta 1 in patients with glomerular disease was analyzed using a ROC curve, and the recovery of the patients was observed. The serum concentrations of CD68 and TGF-beta 1 in the study group were higher than those in the control group (P