Molecular Features and Prognostic Factors of Pleomorphic Xanthoastrocytoma: A Collaborative Investigation of the Tohoku Brain Tumor Study Group
Pleomorphic xanthoastrocytoma (PXA) is a rare glial tumor, however, its histological differentiation from high-grade gliomas is often difficult. Molecular characteristics may contribute to a better diagnostic discrimination. Prognostic factors of PXA are also important but few relevant reports have...
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| creator | ONO, Takahiro SASAJIMA, Toshio SHIMIZU, Hiroaki NATSUMEDA, Manabu KANAMORI, Masayuki ASANO, Kenichiro BEPPU, Takaaki MATSUDA, Kenichiro ICHIKAWA, Masahiro FUJII, Yukihiko OHKUMA, Hiroki OGASAWARA, Kuniaki SONODA, Yukihiko SAITO, Kiyoshi NOBUSAWA, Sumihito NAKAZATO, Yoichi KITANAKA, Chifumi KAYAMA, Takamasa TOMINAGA, Teiji For the Tohoku Brain Tumor Study Group |
| description | Pleomorphic xanthoastrocytoma (PXA) is a rare glial tumor, however, its histological differentiation from high-grade gliomas is often difficult. Molecular characteristics may contribute to a better diagnostic discrimination. Prognostic factors of PXA are also important but few relevant reports have been published. This study investigated the molecular features and prognostic factors of PXAs. Seven university hospitals participated in this study by providing retrospective clinical data and tumor samples of PXA cases between 1993 and 2014. Tumor samples were analyzed for immunohistochemical (IHC) neuronal and glial markers along with Ki67. The status of the BRAF and TERT promoter (TERTp) mutation was also evaluated using the same samples, followed by feature extraction of PXA and survival analyses. In all, 19 primary cases (17 PXA and 2 anaplastic PXA) were included. IHC examination revealed the stable staining of nestin and the close association of synaptophysin to NFP. Of the PXA cases, 57% had the BRAF mutation and only 7% had the TERTp mutation. On univariate analysis, age (≥60 years), preoperative Karnofsky performance status (KPS) (≤80%), and marked peritumoral edema were significantly associated with progression-free survival (PFS). No independent factor was indicated by the multivariate analysis. In conclusion, PXA was characterized by positive nestin staining and a few TERTp mutations. The neuronal differential marker and BRAF status may help in diagnosis. Patient age, preoperative KPS, and marked perifocal edema were associated with PFS. The present study is limited because of small number of cases and its retrospective nature. Further clinical study is needed. |
| doi_str_mv | 10.2176/nmc.oa.2020-0155 |
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Molecular characteristics may contribute to a better diagnostic discrimination. Prognostic factors of PXA are also important but few relevant reports have been published. This study investigated the molecular features and prognostic factors of PXAs. Seven university hospitals participated in this study by providing retrospective clinical data and tumor samples of PXA cases between 1993 and 2014. Tumor samples were analyzed for immunohistochemical (IHC) neuronal and glial markers along with Ki67. The status of the BRAF and TERT promoter (TERTp) mutation was also evaluated using the same samples, followed by feature extraction of PXA and survival analyses. In all, 19 primary cases (17 PXA and 2 anaplastic PXA) were included. IHC examination revealed the stable staining of nestin and the close association of synaptophysin to NFP. Of the PXA cases, 57% had the BRAF mutation and only 7% had the TERTp mutation. On univariate analysis, age (≥60 years), preoperative Karnofsky performance status (KPS) (≤80%), and marked peritumoral edema were significantly associated with progression-free survival (PFS). No independent factor was indicated by the multivariate analysis. In conclusion, PXA was characterized by positive nestin staining and a few TERTp mutations. The neuronal differential marker and BRAF status may help in diagnosis. Patient age, preoperative KPS, and marked perifocal edema were associated with PFS. The present study is limited because of small number of cases and its retrospective nature. Further clinical study is needed.</description><identifier>ISSN: 0470-8105</identifier><identifier>EISSN: 1349-8029</identifier><identifier>DOI: 10.2176/nmc.oa.2020-0155</identifier><identifier>PMID: 33071274</identifier><language>eng</language><publisher>Japan: The Japan Neurosurgical Society</publisher><subject>Astrocytes ; Brain cancer ; Brain tumors ; Central nervous system diseases ; differential diagnosis ; Edema ; Medical prognosis ; Multivariate analysis ; Mutation ; Nestin ; neuronal differentiation ; Neuronal-glial interactions ; Original ; pleomorphic xanthoastrocytoma ; prognostic factors ; Synaptophysin ; TERT promoter mutation</subject><ispartof>Neurologia medico-chirurgica, 2020, Vol.60(11), pp.543-552</ispartof><rights>2020 The Japan Neurosurgical Society</rights><rights>2020. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). 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Med. Chir.(Tokyo)</addtitle><description>Pleomorphic xanthoastrocytoma (PXA) is a rare glial tumor, however, its histological differentiation from high-grade gliomas is often difficult. Molecular characteristics may contribute to a better diagnostic discrimination. Prognostic factors of PXA are also important but few relevant reports have been published. This study investigated the molecular features and prognostic factors of PXAs. Seven university hospitals participated in this study by providing retrospective clinical data and tumor samples of PXA cases between 1993 and 2014. Tumor samples were analyzed for immunohistochemical (IHC) neuronal and glial markers along with Ki67. The status of the BRAF and TERT promoter (TERTp) mutation was also evaluated using the same samples, followed by feature extraction of PXA and survival analyses. In all, 19 primary cases (17 PXA and 2 anaplastic PXA) were included. IHC examination revealed the stable staining of nestin and the close association of synaptophysin to NFP. Of the PXA cases, 57% had the BRAF mutation and only 7% had the TERTp mutation. On univariate analysis, age (≥60 years), preoperative Karnofsky performance status (KPS) (≤80%), and marked peritumoral edema were significantly associated with progression-free survival (PFS). No independent factor was indicated by the multivariate analysis. In conclusion, PXA was characterized by positive nestin staining and a few TERTp mutations. The neuronal differential marker and BRAF status may help in diagnosis. Patient age, preoperative KPS, and marked perifocal edema were associated with PFS. The present study is limited because of small number of cases and its retrospective nature. Further clinical study is needed.</description><subject>Astrocytes</subject><subject>Brain cancer</subject><subject>Brain tumors</subject><subject>Central nervous system diseases</subject><subject>differential diagnosis</subject><subject>Edema</subject><subject>Medical prognosis</subject><subject>Multivariate analysis</subject><subject>Mutation</subject><subject>Nestin</subject><subject>neuronal differentiation</subject><subject>Neuronal-glial interactions</subject><subject>Original</subject><subject>pleomorphic xanthoastrocytoma</subject><subject>prognostic factors</subject><subject>Synaptophysin</subject><subject>TERT promoter 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Investigation of the Tohoku Brain Tumor Study Group</title><author>ONO, Takahiro ; SASAJIMA, Toshio ; SHIMIZU, Hiroaki ; NATSUMEDA, Manabu ; KANAMORI, Masayuki ; ASANO, Kenichiro ; BEPPU, Takaaki ; MATSUDA, Kenichiro ; ICHIKAWA, Masahiro ; FUJII, Yukihiko ; OHKUMA, Hiroki ; OGASAWARA, Kuniaki ; SONODA, Yukihiko ; SAITO, Kiyoshi ; NOBUSAWA, Sumihito ; NAKAZATO, Yoichi ; KITANAKA, Chifumi ; KAYAMA, Takamasa ; TOMINAGA, Teiji ; For the Tohoku Brain Tumor Study Group</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c743t-5f4e394ba86024ab3837f5fe9b33178f4d79ac936e5db7e6384c0c72c0a4734d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Astrocytes</topic><topic>Brain cancer</topic><topic>Brain tumors</topic><topic>Central nervous system diseases</topic><topic>differential diagnosis</topic><topic>Edema</topic><topic>Medical prognosis</topic><topic>Multivariate 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Pathology</creatorcontrib><creatorcontrib>Tohoku University Graduate School of Medicine</creatorcontrib><creatorcontrib>Brain Research Institute</creatorcontrib><creatorcontrib>Yamagata University</creatorcontrib><creatorcontrib>Akita University Graduate School of Medicine</creatorcontrib><creatorcontrib>Department of Neurosurgery</creatorcontrib><creatorcontrib>Niigata University</creatorcontrib><creatorcontrib>Department of Advanced Medicine</creatorcontrib><creatorcontrib>Tohoku Brain Tumor Study Group</creatorcontrib><creatorcontrib>For the Tohoku Brain Tumor Study Group</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neurologia medico-chirurgica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ONO, Takahiro</au><au>SASAJIMA, Toshio</au><au>SHIMIZU, Hiroaki</au><au>NATSUMEDA, Manabu</au><au>KANAMORI, Masayuki</au><au>ASANO, Kenichiro</au><au>BEPPU, Takaaki</au><au>MATSUDA, Kenichiro</au><au>ICHIKAWA, Masahiro</au><au>FUJII, Yukihiko</au><au>OHKUMA, Hiroki</au><au>OGASAWARA, Kuniaki</au><au>SONODA, Yukihiko</au><au>SAITO, Kiyoshi</au><au>NOBUSAWA, Sumihito</au><au>NAKAZATO, Yoichi</au><au>KITANAKA, Chifumi</au><au>KAYAMA, Takamasa</au><au>TOMINAGA, Teiji</au><au>For the Tohoku Brain Tumor Study Group</au><aucorp>Faculty of Medicine</aucorp><aucorp>Gunma University Graduate School of Medicine</aucorp><aucorp>Fukushima Medical University</aucorp><aucorp>Hirosaki University Graduate School of Medicine</aucorp><aucorp>Hidaka Hospital</aucorp><aucorp>Department of Molecular Cancer Science</aucorp><aucorp>Iwate Medical University</aucorp><aucorp>Department of Human Pathology</aucorp><aucorp>Yamagata University School of Medicine</aucorp><aucorp>Department of Pathology</aucorp><aucorp>Tohoku University Graduate School of 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Med. Chir.(Tokyo)</addtitle><date>2020</date><risdate>2020</risdate><volume>60</volume><issue>11</issue><spage>543</spage><epage>552</epage><pages>543-552</pages><issn>0470-8105</issn><eissn>1349-8029</eissn><abstract>Pleomorphic xanthoastrocytoma (PXA) is a rare glial tumor, however, its histological differentiation from high-grade gliomas is often difficult. Molecular characteristics may contribute to a better diagnostic discrimination. Prognostic factors of PXA are also important but few relevant reports have been published. This study investigated the molecular features and prognostic factors of PXAs. Seven university hospitals participated in this study by providing retrospective clinical data and tumor samples of PXA cases between 1993 and 2014. Tumor samples were analyzed for immunohistochemical (IHC) neuronal and glial markers along with Ki67. The status of the BRAF and TERT promoter (TERTp) mutation was also evaluated using the same samples, followed by feature extraction of PXA and survival analyses. In all, 19 primary cases (17 PXA and 2 anaplastic PXA) were included. IHC examination revealed the stable staining of nestin and the close association of synaptophysin to NFP. Of the PXA cases, 57% had the BRAF mutation and only 7% had the TERTp mutation. On univariate analysis, age (≥60 years), preoperative Karnofsky performance status (KPS) (≤80%), and marked peritumoral edema were significantly associated with progression-free survival (PFS). No independent factor was indicated by the multivariate analysis. In conclusion, PXA was characterized by positive nestin staining and a few TERTp mutations. The neuronal differential marker and BRAF status may help in diagnosis. Patient age, preoperative KPS, and marked perifocal edema were associated with PFS. The present study is limited because of small number of cases and its retrospective nature. Further clinical study is needed.</abstract><cop>Japan</cop><pub>The Japan Neurosurgical Society</pub><pmid>33071274</pmid><doi>10.2176/nmc.oa.2020-0155</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0470-8105 |
| ispartof | Neurologia medico-chirurgica, 2020, Vol.60(11), pp.543-552 |
| issn | 0470-8105 1349-8029 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7788268 |
| source | J-STAGE Free; DOAJ Directory of Open Access Journals; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Astrocytes Brain cancer Brain tumors Central nervous system diseases differential diagnosis Edema Medical prognosis Multivariate analysis Mutation Nestin neuronal differentiation Neuronal-glial interactions Original pleomorphic xanthoastrocytoma prognostic factors Synaptophysin TERT promoter mutation |
| title | Molecular Features and Prognostic Factors of Pleomorphic Xanthoastrocytoma: A Collaborative Investigation of the Tohoku Brain Tumor Study Group |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T23%3A28%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Molecular%20Features%20and%20Prognostic%20Factors%20of%20Pleomorphic%20Xanthoastrocytoma:%20A%20Collaborative%20Investigation%20of%20the%20Tohoku%20Brain%20Tumor%20Study%20Group&rft.jtitle=Neurologia%20medico-chirurgica&rft.au=ONO,%20Takahiro&rft.aucorp=Faculty%20of%20Medicine&rft.date=2020&rft.volume=60&rft.issue=11&rft.spage=543&rft.epage=552&rft.pages=543-552&rft.issn=0470-8105&rft.eissn=1349-8029&rft_id=info:doi/10.2176/nmc.oa.2020-0155&rft_dat=%3Cproquest_pubme%3E2468151328%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2468151328&rft_id=info:pmid/33071274&rfr_iscdi=true |