Effect of l-Carnosine as adjunctive therapy in the management of children with autism spectrum disorder: a randomized controlled study

l -Carnosine is an amino acid that acts as an anti-oxidant, anti-toxic and neuroprotective agent. There is a paucity of data about the effectiveness of l -Carnosine in the management of autism spectrum disorder (ASD) in children. This study aimed at investigating the effectiveness of l -Carnosine as...

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Veröffentlicht in:Amino acids 2020-12, Vol.52 (11-12), p.1521-1528
Hauptverfasser: Ann Abraham, Debi, Narasimhan, Udayakumar, Christy, Senta, Muhasaparur Ganesan, Rajanandh
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Sprache:eng
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Zusammenfassung:l -Carnosine is an amino acid that acts as an anti-oxidant, anti-toxic and neuroprotective agent. There is a paucity of data about the effectiveness of l -Carnosine in the management of autism spectrum disorder (ASD) in children. This study aimed at investigating the effectiveness of l -Carnosine as adjunctive therapy in the management of ASD. This was a randomized controlled trial. Children aged 3–6 years with a diagnosis of mild to moderate ASD were assigned to standard care arm (occupational and speech therapy) and intervention care arm ( l -Carnosine, 10–15 mg/kg in 2 divided doses) plus standard care treatment. The children were assessed at the baseline and the end of 2 months for the scores of Childhood Autism Rating Scale, Second Edition—Standard Version (CARS2-ST), Autism Treatment Evaluation Checklist (ATEC), BEARS sleep screening tool and 6-item Gastrointestinal Severity Index (6-GSI). Of the sixty-seven children enrolled, sixty-three children had completed the study. No statistically significant difference ( p  > 0.05) was observed for any of the outcome measures assessed. Supplementation of l -Carnosine did not improve the total score of CARS2-ST, ATEC, BEARS sleep screening tool and 6-GSI scores of children with ASD. Further investigations are needed with more objective assessments to critically validate the effectiveness of l -Carnosine on ASD children for more decisive results.
ISSN:0939-4451
1438-2199
DOI:10.1007/s00726-020-02909-1