Enantioselective Synthesis of Tetrahydroquinolines via One‐Pot Cascade Biomimetic Reduction

Summary of main observation and conclusion A novel and efficient protocol for the synthesis of chiral tetrahydroquinoline derivatives with excellent enantioselectivities and high yields has been developed through one‐pot cascade biomimetic reduction. The detailed reaction pathway includes the acid‐catalyzed and ruthenium‐catalyzed formation of aromatic quinoline intermediates and biomimetic asymmetric reduction. A novel and efficient approach to chiral tetrahydroquinolines with excellent enantioselectivities and high yields has been described via one‐pot cascade biomimetic reduction. Furthermore, the detailed reaction pathway includes the acid‐catalyzed and ruthenium‐catalyzed formation of aromatic quinoline intermediates and biomimetic asymmetric reduction.