Formation of Monofluorinated Radical Cofactor in Galactose Oxidase through Copper-Mediated C–F Bond Scission

Galactose oxidase (GAO) contains a Cu(II)-ligand radical cofactor. The cofactor, which is autocatalytically generated through the oxidation of the copper, consists of a cysteine-tyrosine radical (Cys-Tyr•) as a copper ligand. The formation of the cross-linked thioether bond is accompanied by a C–H...

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Veröffentlicht in:	Journal of the American Chemical Society 2020-11, Vol.142 (44), p.18753-18757
Hauptverfasser:	Li, Jiasong, Davis, Ian, Griffith, Wendell P, Liu, Aimin
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbon - chemistry Catalysis Copper - chemistry Crystallography, X-Ray Directed Molecular Evolution Electron Spin Resonance Spectroscopy Fluorine - chemistry Free Radicals - chemistry Galactose Oxidase - chemistry Galactose Oxidase - genetics Galactose Oxidase - metabolism Kinetics Ligands Mutagenesis, Site-Directed Oxidation-Reduction Protein Structure, Tertiary Tyrosine - analogs & derivatives Tyrosine - chemistry Tyrosine - metabolism
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