6‐phenylpyrrolocytosine as a fluorescent probe to examine nucleotide flipping catalyzed by a DNA repair protein

Cellular exposure to tobacco‐specific nitrosamines causes formation of promutagenic O6‐[4‐oxo‐4‐(3‐pyridyl)but‐1‐yl]guanine (O6‐POB‐G) and O6‐methylguanine (O6‐Me‐G) adducts in DNA. These adducts can be directly repaired by O6‐alkylguanine‐DNA alkyltransferase (AGT). Repair begins by flipping the da...

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Veröffentlicht in:	BIOPOLYMERS 2021-01, Vol.112 (1), p.e23405-n/a, Article 23405
Hauptverfasser:	Kotandeniya, Delshanee, Rogers, Melanie S., Fernandez, Jenna, Kanugula, Sreenivas, Hudson, Robert H. E., Rodriguez, Freddys, Lipscomb, John D., Tretyakova, Natalia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adducts Alkylation alkylguanine Base Pairing base‐flipping Binding Biocatalysis Biochemistry & Molecular Biology Biophysics Codons CpG islands CpG Islands - genetics Cytidine - analogs & derivatives Cytidine - chemistry Cytosine Cytosine - chemistry dealkylation Deoxyribonucleic acid DNA DNA adducts DNA Adducts - chemistry DNA Adducts - metabolism DNA alkyltransferase DNA Repair Fluorescent Dyes - chemistry Fluorescent indicators fluorescent probe Guanine Kinetics Life Sciences & Biomedicine Methylguanine Mutagenesis, Site-Directed Nitrosamines Nucleotides O-Methylguanine-DNA Methyltransferase - metabolism p53 Protein Pyrroles - chemistry Repair Science & Technology Tobacco transient kinetics Tumor suppressor genes Tumor Suppressor Protein p53 - genetics
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