Premature aging syndrome showing random chromosome number instabilities with CDC20 mutation

Damage to the genome can accelerate aging. The percentage of aneuploid cells, that is, cells with an abnormal number of chromosomes, increases during aging; however, it is not clear whether increased aneuploidy accelerates aging. Here, we report an individual showing premature aging phenotypes of va...

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Veröffentlicht in:	Aging cell 2020-11, Vol.19 (11), p.e13251-n/a, Article 13251
Hauptverfasser:	Fujita, Harumi, Sasaki, Takashi, Miyamoto, Tatsuo, Akutsu, Silvia Natsuko, Sato, Showbu, Mori, Takehiko, Nakabayashi, Kazuhiko, Hata, Kenichiro, Suzuki, Hisato, Kosaki, Kenjiro, Matsuura, Shinya, Matsubara, Yoichi, Amagai, Masayuki, Kubo, Akiharu
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging Anaphase Anaphase-promoting complex Anemia Aneuploidy Atrophy Binding sites Biopsy Bone marrow BUBR1 protein Cdc20 proteins Cell Biology Cell cycle chromosomal instability Chromosome number chromosome segregation Chromosomes Deoxyribonucleic acid DNA Genetic aspects Genomes genomic instability Genomics Geriatrics & Gerontology Hematopoietic stem cells Intellectual disabilities Life Sciences & Biomedicine M phase cell cycle checkpoints Microcephaly Missense mutation Mutants Mutation Original Original Paper Phenotypes premature Proteins Science & Technology Stem cells
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