Preparation of amphiphilic magnetic polyvinyl alcohol targeted drug carrier and drug delivery research
Currently, magnetic applications have great potential for development in the field of drug carriers. In this paper, Fe 3 O 4 -PVA@SH, an amphiphilic magnetically targeting drug carrier, was prepared by using Fe 3 O 4 and PVA with thiohydrazide-iminopropyltriethoxysilane(TIPTS). The loading capacity...
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| Veröffentlicht in: | Designed monomers and polymers 2020-01, Vol.23 (1), p.197-206 |
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| creator | Wang, Yazhen Shi, Zhen Sun, Yu Wu, Xueying Li, Shuang Dong, Shaobo Lan, Tianyu |
| description | Currently, magnetic applications have great potential for development in the field of drug carriers. In this paper, Fe
3
O
4
-PVA@SH, an amphiphilic magnetically targeting drug carrier, was prepared by using Fe
3
O
4
and PVA with thiohydrazide-iminopropyltriethoxysilane(TIPTS). The loading capacity of Fe
3
O
4
-PVA@SH on Aspirin and the drug release kinetics of loaded drugs were studied. The obtained Fe
3
O
4
-PVA@SH exhibits excellent drug release properties in simulating the human body fluid environment (pH 7.2). Since magnetically targeting drug carriers are readily available and have excellent biocompatibility and the characteristics of drug release. This work's development, preparing amphiphilic magnetically targeting drug carriers in drug delivery and other fields, has great significance. |
| doi_str_mv | 10.1080/15685551.2020.1837442 |
| format | Article |
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3
O
4
-PVA@SH, an amphiphilic magnetically targeting drug carrier, was prepared by using Fe
3
O
4
and PVA with thiohydrazide-iminopropyltriethoxysilane(TIPTS). The loading capacity of Fe
3
O
4
-PVA@SH on Aspirin and the drug release kinetics of loaded drugs were studied. The obtained Fe
3
O
4
-PVA@SH exhibits excellent drug release properties in simulating the human body fluid environment (pH 7.2). Since magnetically targeting drug carriers are readily available and have excellent biocompatibility and the characteristics of drug release. This work's development, preparing amphiphilic magnetically targeting drug carriers in drug delivery and other fields, has great significance.</description><identifier>ISSN: 1385-772X</identifier><identifier>ISSN: 1568-5551</identifier><identifier>EISSN: 1568-5551</identifier><identifier>DOI: 10.1080/15685551.2020.1837442</identifier><identifier>PMID: 33177950</identifier><language>eng</language><publisher>ABINGDON: Taylor & Francis</publisher><subject>amphiphilic ; Aspirin ; Biocompatibility ; Body fluids ; Drug carriers ; fe3o4 ; Iron oxides ; magnetic ; Physical Sciences ; Poly(vinyl alcohol) ; Polymer Science ; Polyvinyl alcohol ; Science & Technology ; targeted drug delivery</subject><ispartof>Designed monomers and polymers, 2020-01, Vol.23 (1), p.197-206</ispartof><rights>2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2020</rights><rights>2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.</rights><rights>2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2020 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>8</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000581122700001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c599t-3eb304c0ab1261f153ad4895d2e0427dc794e6ddcc18fbef60269d2f8ba24aef3</citedby><cites>FETCH-LOGICAL-c599t-3eb304c0ab1261f153ad4895d2e0427dc794e6ddcc18fbef60269d2f8ba24aef3</cites><orcidid>0000-0001-9314-5222</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594732/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594732/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2115,27507,27929,27930,28253,53796,53798,59148,59149</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33177950$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Yazhen</creatorcontrib><creatorcontrib>Shi, Zhen</creatorcontrib><creatorcontrib>Sun, Yu</creatorcontrib><creatorcontrib>Wu, Xueying</creatorcontrib><creatorcontrib>Li, Shuang</creatorcontrib><creatorcontrib>Dong, Shaobo</creatorcontrib><creatorcontrib>Lan, Tianyu</creatorcontrib><title>Preparation of amphiphilic magnetic polyvinyl alcohol targeted drug carrier and drug delivery research</title><title>Designed monomers and polymers</title><addtitle>DES MONOMERS POLYM</addtitle><addtitle>Des Monomers Polym</addtitle><description>Currently, magnetic applications have great potential for development in the field of drug carriers. In this paper, Fe
3
O
4
-PVA@SH, an amphiphilic magnetically targeting drug carrier, was prepared by using Fe
3
O
4
and PVA with thiohydrazide-iminopropyltriethoxysilane(TIPTS). The loading capacity of Fe
3
O
4
-PVA@SH on Aspirin and the drug release kinetics of loaded drugs were studied. The obtained Fe
3
O
4
-PVA@SH exhibits excellent drug release properties in simulating the human body fluid environment (pH 7.2). Since magnetically targeting drug carriers are readily available and have excellent biocompatibility and the characteristics of drug release. This work's development, preparing amphiphilic magnetically targeting drug carriers in drug delivery and other fields, has great significance.</description><subject>amphiphilic</subject><subject>Aspirin</subject><subject>Biocompatibility</subject><subject>Body fluids</subject><subject>Drug carriers</subject><subject>fe3o4</subject><subject>Iron oxides</subject><subject>magnetic</subject><subject>Physical Sciences</subject><subject>Poly(vinyl alcohol)</subject><subject>Polymer Science</subject><subject>Polyvinyl alcohol</subject><subject>Science & Technology</subject><subject>targeted drug delivery</subject><issn>1385-772X</issn><issn>1568-5551</issn><issn>1568-5551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>AOWDO</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl2L1DAUhoso7rr6E5SCN4LMms-mvZGVwY-FBb1Q8C6cJiczGdJmTNtZ5t-b7swOrhciBHJ4z3NecsJbFC8puaSkJu-orGopJb1khGWp5koI9qg4n_XF3Hica17LhVLs51nxbBg2hDDOa_G0OOOcKtVIcl64bwm3kGD0sS-jK6Hbrn0-wZuyg1WPYy62Mex3vt-HEoKJ6xjKEdIKR7SlTdOqNJCSx1RCfxQsBr_DtC8TDgjJrJ8XTxyEAV8c74vix6eP35dfFjdfP18vP9wsjGyaccGx5UQYAi1lFXVUcrCibqRlSART1qhGYGWtMbR2LbqKsKqxzNUtMAHo-EVxffC1ETZ6m3wHaa8jeH0nxLTSkPJKAbVV1LgGiUPVCiC0gZYLKRxjragEquz1_uC1ndoOrcF-TBAemD7s9H6tV3GnlWyE4iwbvDkapPhrwmHUnR8MhgA9xmnQTFSE1IwzmdHXf6GbOKU-f9VMNUrIhs6UPFAmxWFI6E6PoUTPqdD3qdBzKvQxFXnu1Z-bnKbuY5CBtwfgFtvoBuOxN3jCCCGyppQxlStCM13_P7304124lnHqxzx6dRj1vYupg9uYgtUj7ENMLkFv_KD5v5f5DboW6dg</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Wang, Yazhen</creator><creator>Shi, Zhen</creator><creator>Sun, Yu</creator><creator>Wu, Xueying</creator><creator>Li, Shuang</creator><creator>Dong, Shaobo</creator><creator>Lan, Tianyu</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7SR</scope><scope>7XB</scope><scope>8FD</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>JG9</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-9314-5222</orcidid></search><sort><creationdate>20200101</creationdate><title>Preparation of amphiphilic magnetic polyvinyl alcohol targeted drug carrier and drug delivery research</title><author>Wang, Yazhen ; Shi, Zhen ; Sun, Yu ; Wu, Xueying ; Li, Shuang ; Dong, Shaobo ; Lan, Tianyu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c599t-3eb304c0ab1261f153ad4895d2e0427dc794e6ddcc18fbef60269d2f8ba24aef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>amphiphilic</topic><topic>Aspirin</topic><topic>Biocompatibility</topic><topic>Body fluids</topic><topic>Drug carriers</topic><topic>fe3o4</topic><topic>Iron oxides</topic><topic>magnetic</topic><topic>Physical Sciences</topic><topic>Poly(vinyl alcohol)</topic><topic>Polymer Science</topic><topic>Polyvinyl alcohol</topic><topic>Science & Technology</topic><topic>targeted drug delivery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Yazhen</creatorcontrib><creatorcontrib>Shi, Zhen</creatorcontrib><creatorcontrib>Sun, Yu</creatorcontrib><creatorcontrib>Wu, Xueying</creatorcontrib><creatorcontrib>Li, Shuang</creatorcontrib><creatorcontrib>Dong, Shaobo</creatorcontrib><creatorcontrib>Lan, Tianyu</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Engineered Materials Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Technology Research Database</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Materials Research Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Designed monomers and polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Yazhen</au><au>Shi, Zhen</au><au>Sun, Yu</au><au>Wu, Xueying</au><au>Li, Shuang</au><au>Dong, Shaobo</au><au>Lan, Tianyu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation of amphiphilic magnetic polyvinyl alcohol targeted drug carrier and drug delivery research</atitle><jtitle>Designed monomers and polymers</jtitle><stitle>DES MONOMERS POLYM</stitle><addtitle>Des Monomers Polym</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>23</volume><issue>1</issue><spage>197</spage><epage>206</epage><pages>197-206</pages><issn>1385-772X</issn><issn>1568-5551</issn><eissn>1568-5551</eissn><abstract>Currently, magnetic applications have great potential for development in the field of drug carriers. In this paper, Fe
3
O
4
-PVA@SH, an amphiphilic magnetically targeting drug carrier, was prepared by using Fe
3
O
4
and PVA with thiohydrazide-iminopropyltriethoxysilane(TIPTS). The loading capacity of Fe
3
O
4
-PVA@SH on Aspirin and the drug release kinetics of loaded drugs were studied. The obtained Fe
3
O
4
-PVA@SH exhibits excellent drug release properties in simulating the human body fluid environment (pH 7.2). Since magnetically targeting drug carriers are readily available and have excellent biocompatibility and the characteristics of drug release. This work's development, preparing amphiphilic magnetically targeting drug carriers in drug delivery and other fields, has great significance.</abstract><cop>ABINGDON</cop><pub>Taylor & Francis</pub><pmid>33177950</pmid><doi>10.1080/15685551.2020.1837442</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-9314-5222</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | amphiphilic Aspirin Biocompatibility Body fluids Drug carriers fe3o4 Iron oxides magnetic Physical Sciences Poly(vinyl alcohol) Polymer Science Polyvinyl alcohol Science & Technology targeted drug delivery |
| title | Preparation of amphiphilic magnetic polyvinyl alcohol targeted drug carrier and drug delivery research |
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