The Antimicrobial Cathelicidin CRAMP Augments Platelet Activation during Psoriasis in Mice

Platelet-associated complications including thrombosis, thrombocytopenia, and haemorrhage are commonly observed during various inflammatory diseases such as psoriasis. Although several mechanisms that may contribute to the dysfunction of platelets during inflammatory diseases have been reported, kno...

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Veröffentlicht in:	Biomolecules (Basel, Switzerland) Switzerland), 2020-09, Vol.10 (9), p.1267, Article 1267
Hauptverfasser:	Salamah, Maryam F., Vallance, Thomas M., Kodji, Xenia, Ravishankar, Divyashree, Williams, Harry F., Brain, Susan D., Vaiyapuri, Sakthivel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antimicrobial agents Antimicrobial Cationic Peptides - metabolism Antimicrobial Cationic Peptides - pharmacology Antimicrobial peptides Arteriosclerosis Atherosclerosis Bacteria Biochemistry & Molecular Biology Blood platelets Blood Platelets - drug effects Blood Platelets - metabolism Disease Models, Animal Erythema Fibrinogen Fibrinogen - metabolism Flow cytometry Hemorrhage Hemostasis - drug effects Imiquimod Imiquimod - toxicity inflammation Inflammatory bowel disease Inflammatory bowel diseases Inflammatory diseases Intestine Life Sciences & Biomedicine mCRAMP Mice, Inbred C57BL P-selectin P-Selectin - blood Peptides Platelet Activation - drug effects Platelets Psoriasis Psoriasis - blood Psoriasis vulgaris Receptors, Formyl Peptide - metabolism Science & Technology Skin Skin - metabolism Skin - pathology Statistical analysis Thrombocytopenia thromboinflammation Thrombosis
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