Smell and Taste Dysfunction in COVID-19 Is Associated With Younger Age in Ambulatory Settings: A Multicenter Cross-Sectional Study
Background: Since the initial anecdotal reports of coronavirus disease 2019 (COVID-19) from China, a growing number of studies have reported on smell and/or taste dysfunction (STD). Objective:The aim of our study was to investigate the frequency and severity of STD in COVID-19 patients and to evalua...
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| Veröffentlicht in: | Journal of investigational allergology & clinical immunology 2020-01, Vol.30 (5), p.346-357 |
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| creator | Izquierdo-Dominguez, A. Rojas-Lechuga, M. J. Chiesa-Estomba, C. Calvo-Henriquez, C. Ninchritz-Becerra, E. Soriano-Reixach, M. Poletti-Serafini, D. Villarreal, I. M. Maza-Solano, J. M. Moreno-Luna, R. Villarroel, P. P. Mateos-Serrano, B. Agudelo, D. Valcarcel, F. del Cuvillo, A. Santamaria, A. Marino-Sanchez, F. Aguilar, J. Verges, P. Inciarte, A. Soriano, A. Mullol, J. Alobid |
| description | Background: Since the initial anecdotal reports of coronavirus disease 2019 (COVID-19) from China, a growing number of studies have reported on smell and/or taste dysfunction (STD).
Objective:The aim of our study was to investigate the frequency and severity of STD in COVID-19 patients and to evaluate the association with demographic characteristics, hospital admission, symptoms, comorbidities, and blood biomarkers.
Methods: We performed a multicenter cross-sectional study on patients who were positive for SARS-CoV-2 (n=846) and controls (n=143) from 15 Spanish hospitals. Data on STD were collected prospectively using an in-person survey. The severity of STD was categorized using a visual analog scale. We analyzed time to onset recovery rate, time to recovery, hospital admission, pneumonia, comorbidities, smoking, and symptoms.
Results: STD was at least 2-fold more common in COVID-19-positive patients than in controls. COVID-19-positive hospitalized patients were older, with a lower frequency of STD, and recovered earlier than outpatients. Analysis stratified by severity of STD showed that more than half of COVID-19 patients presented severe loss of smell (53.7%) or taste (52.2%); both senses were impaired in >90%. In the multivariate analysis, older age (>60 years), being hospitalized, and increased C-reactive protein were associated with a better sense of smell and/or taste. COVID-19-positive patients reported improvement in smell (45.6%) and taste (46.1%) at the time of the survey; in 90.6% this was within 2 weeks of infection.
Conclusion: STD is a common symptom in COVID-19 and presents mainly in young and nonhospitalized patients. More studies are needed to evaluate follow-up of chemosensory impairment. |
| doi_str_mv | 10.18176/jiaci.0595 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_webof</sourceid><recordid>TN_cdi_webofscience_primary_000579354400006</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2415297710</sourcerecordid><originalsourceid>FETCH-LOGICAL-c354t-6ac538e74533be81583be09009982fe4acc4a287679ff82c609bbc41c0b358103</originalsourceid><addsrcrecordid>eNqN0bFv1DAUBvAIUdGq7cSOLLEgobTPsR3bbFFK4aSiDldATJHjezlcJU6JHaFb-5fjXEuROjG9N_z0yc9flr2mcEYVleX5rTPWnYHQ4kV2REutclCgXqYdqMo1lOowOw3BtQBKgJBSvsoOWSEEZ0weZffrAfueGL8hNyZEJBe70M3eRjd64jypr7-tLnKqySqQKoTROhNxQ767-JP8GGe_xYlUW1xoNbRzb-I47cgaY3R-Gz6QinyZ--gs-phkPY0h5Gvcx5uerOO82Z1kB53pA54-zuPs6-XHm_pzfnX9aVVXV7llgse8NFYwhZILxlpUVKg0QANorYoOubGWm0LJUuquU4UtQbet5dRCy4SiwI6zdw-5d9P4a8YQm8EFm643Hsc5NAWnotBS7unbZ_R2nKf04kUJKgTTwJN6_6DsctaEXXM3ucFMu4ZCs2-n2bfTLO0k_eYxc24H3DzZv138i_uN7dgF69BbfGIAqTydfoKnDcqk1f_r2kWzfHmdGovsDzL0qko</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2451553904</pqid></control><display><type>article</type><title>Smell and Taste Dysfunction in COVID-19 Is Associated With Younger Age in Ambulatory Settings: A Multicenter Cross-Sectional Study</title><source>MEDLINE</source><source>Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Izquierdo-Dominguez, A. ; Rojas-Lechuga, M. J. ; Chiesa-Estomba, C. ; Calvo-Henriquez, C. ; Ninchritz-Becerra, E. ; Soriano-Reixach, M. ; Poletti-Serafini, D. ; Villarreal, I. M. ; Maza-Solano, J. M. ; Moreno-Luna, R. ; Villarroel, P. P. ; Mateos-Serrano, B. ; Agudelo, D. ; Valcarcel, F. ; del Cuvillo, A. ; Santamaria, A. ; Marino-Sanchez, F. ; Aguilar, J. ; Verges, P. ; Inciarte, A. ; Soriano, A. ; Mullol, J. ; Alobid</creator><creatorcontrib>Izquierdo-Dominguez, A. ; Rojas-Lechuga, M. J. ; Chiesa-Estomba, C. ; Calvo-Henriquez, C. ; Ninchritz-Becerra, E. ; Soriano-Reixach, M. ; Poletti-Serafini, D. ; Villarreal, I. M. ; Maza-Solano, J. M. ; Moreno-Luna, R. ; Villarroel, P. P. ; Mateos-Serrano, B. ; Agudelo, D. ; Valcarcel, F. ; del Cuvillo, A. ; Santamaria, A. ; Marino-Sanchez, F. ; Aguilar, J. ; Verges, P. ; Inciarte, A. ; Soriano, A. ; Mullol, J. ; Alobid</creatorcontrib><description>Background: Since the initial anecdotal reports of coronavirus disease 2019 (COVID-19) from China, a growing number of studies have reported on smell and/or taste dysfunction (STD).
Objective:The aim of our study was to investigate the frequency and severity of STD in COVID-19 patients and to evaluate the association with demographic characteristics, hospital admission, symptoms, comorbidities, and blood biomarkers.
Methods: We performed a multicenter cross-sectional study on patients who were positive for SARS-CoV-2 (n=846) and controls (n=143) from 15 Spanish hospitals. Data on STD were collected prospectively using an in-person survey. The severity of STD was categorized using a visual analog scale. We analyzed time to onset recovery rate, time to recovery, hospital admission, pneumonia, comorbidities, smoking, and symptoms.
Results: STD was at least 2-fold more common in COVID-19-positive patients than in controls. COVID-19-positive hospitalized patients were older, with a lower frequency of STD, and recovered earlier than outpatients. Analysis stratified by severity of STD showed that more than half of COVID-19 patients presented severe loss of smell (53.7%) or taste (52.2%); both senses were impaired in >90%. In the multivariate analysis, older age (>60 years), being hospitalized, and increased C-reactive protein were associated with a better sense of smell and/or taste. COVID-19-positive patients reported improvement in smell (45.6%) and taste (46.1%) at the time of the survey; in 90.6% this was within 2 weeks of infection.
Conclusion: STD is a common symptom in COVID-19 and presents mainly in young and nonhospitalized patients. More studies are needed to evaluate follow-up of chemosensory impairment.</description><identifier>ISSN: 1018-9068</identifier><identifier>EISSN: 1698-0808</identifier><identifier>DOI: 10.18176/jiaci.0595</identifier><identifier>PMID: 32554337</identifier><language>eng</language><publisher>BARCELONA: Esmon Publicidad S A, Dept Allergy & Clin Immunol, Clin Univ Navarra</publisher><subject>Adult ; Age Factors ; Aged ; Aged, 80 and over ; Allergy ; Betacoronavirus - genetics ; Betacoronavirus - immunology ; C-reactive protein ; Case-Control Studies ; Chemoreception ; Coronavirus Infections - complications ; Coronavirus Infections - diagnosis ; Coronavirus Infections - epidemiology ; Coronavirus Infections - virology ; Coronaviruses ; COVID-19 ; Cross-Sectional Studies ; Female ; Hospitalization ; Humans ; Immunology ; Life Sciences & Biomedicine ; Male ; Middle Aged ; Multivariate analysis ; Olfaction ; Olfaction Disorders - diagnosis ; Olfaction Disorders - epidemiology ; Olfaction Disorders - etiology ; Pandemics ; Patients ; Pneumonia, Viral - complications ; Pneumonia, Viral - diagnosis ; Pneumonia, Viral - epidemiology ; Pneumonia, Viral - virology ; Polymerase Chain Reaction ; Public Health Surveillance ; SARS-CoV-2 ; Science & Technology ; Severe acute respiratory syndrome coronavirus 2 ; Severity of Illness Index ; Spain - epidemiology ; Symptom Assessment ; Taste ; Taste Disorders - diagnosis ; Taste Disorders - epidemiology ; Taste Disorders - etiology ; Young Adult</subject><ispartof>Journal of investigational allergology & clinical immunology, 2020-01, Vol.30 (5), p.346-357</ispartof><rights>Copyright Esmon Publicidad 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>71</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000579354400006</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c354t-6ac538e74533be81583be09009982fe4acc4a287679ff82c609bbc41c0b358103</citedby><cites>FETCH-LOGICAL-c354t-6ac538e74533be81583be09009982fe4acc4a287679ff82c609bbc41c0b358103</cites><orcidid>0000-0003-1896-3457 ; 0000-0002-3588-9095 ; 0000-0002-9374-0811 ; 0000-0003-0640-0550 ; 0000-0001-8096-4659 ; 0000-0002-1402-5167 ; 0000-0003-3580-0967</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27933,27934,28257</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32554337$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Izquierdo-Dominguez, A.</creatorcontrib><creatorcontrib>Rojas-Lechuga, M. J.</creatorcontrib><creatorcontrib>Chiesa-Estomba, C.</creatorcontrib><creatorcontrib>Calvo-Henriquez, C.</creatorcontrib><creatorcontrib>Ninchritz-Becerra, E.</creatorcontrib><creatorcontrib>Soriano-Reixach, M.</creatorcontrib><creatorcontrib>Poletti-Serafini, D.</creatorcontrib><creatorcontrib>Villarreal, I. M.</creatorcontrib><creatorcontrib>Maza-Solano, J. M.</creatorcontrib><creatorcontrib>Moreno-Luna, R.</creatorcontrib><creatorcontrib>Villarroel, P. P.</creatorcontrib><creatorcontrib>Mateos-Serrano, B.</creatorcontrib><creatorcontrib>Agudelo, D.</creatorcontrib><creatorcontrib>Valcarcel, F.</creatorcontrib><creatorcontrib>del Cuvillo, A.</creatorcontrib><creatorcontrib>Santamaria, A.</creatorcontrib><creatorcontrib>Marino-Sanchez, F.</creatorcontrib><creatorcontrib>Aguilar, J.</creatorcontrib><creatorcontrib>Verges, P.</creatorcontrib><creatorcontrib>Inciarte, A.</creatorcontrib><creatorcontrib>Soriano, A.</creatorcontrib><creatorcontrib>Mullol, J.</creatorcontrib><creatorcontrib>Alobid</creatorcontrib><title>Smell and Taste Dysfunction in COVID-19 Is Associated With Younger Age in Ambulatory Settings: A Multicenter Cross-Sectional Study</title><title>Journal of investigational allergology & clinical immunology</title><addtitle>J INVEST ALLERG CLIN</addtitle><addtitle>J Investig Allergol Clin Immunol</addtitle><description>Background: Since the initial anecdotal reports of coronavirus disease 2019 (COVID-19) from China, a growing number of studies have reported on smell and/or taste dysfunction (STD).
Objective:The aim of our study was to investigate the frequency and severity of STD in COVID-19 patients and to evaluate the association with demographic characteristics, hospital admission, symptoms, comorbidities, and blood biomarkers.
Methods: We performed a multicenter cross-sectional study on patients who were positive for SARS-CoV-2 (n=846) and controls (n=143) from 15 Spanish hospitals. Data on STD were collected prospectively using an in-person survey. The severity of STD was categorized using a visual analog scale. We analyzed time to onset recovery rate, time to recovery, hospital admission, pneumonia, comorbidities, smoking, and symptoms.
Results: STD was at least 2-fold more common in COVID-19-positive patients than in controls. COVID-19-positive hospitalized patients were older, with a lower frequency of STD, and recovered earlier than outpatients. Analysis stratified by severity of STD showed that more than half of COVID-19 patients presented severe loss of smell (53.7%) or taste (52.2%); both senses were impaired in >90%. In the multivariate analysis, older age (>60 years), being hospitalized, and increased C-reactive protein were associated with a better sense of smell and/or taste. COVID-19-positive patients reported improvement in smell (45.6%) and taste (46.1%) at the time of the survey; in 90.6% this was within 2 weeks of infection.
Conclusion: STD is a common symptom in COVID-19 and presents mainly in young and nonhospitalized patients. More studies are needed to evaluate follow-up of chemosensory impairment.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Allergy</subject><subject>Betacoronavirus - genetics</subject><subject>Betacoronavirus - immunology</subject><subject>C-reactive protein</subject><subject>Case-Control Studies</subject><subject>Chemoreception</subject><subject>Coronavirus Infections - complications</subject><subject>Coronavirus Infections - diagnosis</subject><subject>Coronavirus Infections - epidemiology</subject><subject>Coronavirus Infections - virology</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Immunology</subject><subject>Life Sciences & Biomedicine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Olfaction</subject><subject>Olfaction Disorders - diagnosis</subject><subject>Olfaction Disorders - epidemiology</subject><subject>Olfaction Disorders - etiology</subject><subject>Pandemics</subject><subject>Patients</subject><subject>Pneumonia, Viral - complications</subject><subject>Pneumonia, Viral - diagnosis</subject><subject>Pneumonia, Viral - epidemiology</subject><subject>Pneumonia, Viral - virology</subject><subject>Polymerase Chain Reaction</subject><subject>Public Health Surveillance</subject><subject>SARS-CoV-2</subject><subject>Science & Technology</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Severity of Illness Index</subject><subject>Spain - epidemiology</subject><subject>Symptom Assessment</subject><subject>Taste</subject><subject>Taste Disorders - diagnosis</subject><subject>Taste Disorders - epidemiology</subject><subject>Taste Disorders - etiology</subject><subject>Young Adult</subject><issn>1018-9068</issn><issn>1698-0808</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><recordid>eNqN0bFv1DAUBvAIUdGq7cSOLLEgobTPsR3bbFFK4aSiDldATJHjezlcJU6JHaFb-5fjXEuROjG9N_z0yc9flr2mcEYVleX5rTPWnYHQ4kV2REutclCgXqYdqMo1lOowOw3BtQBKgJBSvsoOWSEEZ0weZffrAfueGL8hNyZEJBe70M3eRjd64jypr7-tLnKqySqQKoTROhNxQ767-JP8GGe_xYlUW1xoNbRzb-I47cgaY3R-Gz6QinyZ--gs-phkPY0h5Gvcx5uerOO82Z1kB53pA54-zuPs6-XHm_pzfnX9aVVXV7llgse8NFYwhZILxlpUVKg0QANorYoOubGWm0LJUuquU4UtQbet5dRCy4SiwI6zdw-5d9P4a8YQm8EFm643Hsc5NAWnotBS7unbZ_R2nKf04kUJKgTTwJN6_6DsctaEXXM3ucFMu4ZCs2-n2bfTLO0k_eYxc24H3DzZv138i_uN7dgF69BbfGIAqTydfoKnDcqk1f_r2kWzfHmdGovsDzL0qko</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Izquierdo-Dominguez, A.</creator><creator>Rojas-Lechuga, M. J.</creator><creator>Chiesa-Estomba, C.</creator><creator>Calvo-Henriquez, C.</creator><creator>Ninchritz-Becerra, E.</creator><creator>Soriano-Reixach, M.</creator><creator>Poletti-Serafini, D.</creator><creator>Villarreal, I. M.</creator><creator>Maza-Solano, J. M.</creator><creator>Moreno-Luna, R.</creator><creator>Villarroel, P. P.</creator><creator>Mateos-Serrano, B.</creator><creator>Agudelo, D.</creator><creator>Valcarcel, F.</creator><creator>del Cuvillo, A.</creator><creator>Santamaria, A.</creator><creator>Marino-Sanchez, F.</creator><creator>Aguilar, J.</creator><creator>Verges, P.</creator><creator>Inciarte, A.</creator><creator>Soriano, A.</creator><creator>Mullol, J.</creator><creator>Alobid</creator><general>Esmon Publicidad S A, Dept Allergy & Clin Immunol, Clin Univ Navarra</general><general>Esmon Publicidad</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1896-3457</orcidid><orcidid>https://orcid.org/0000-0002-3588-9095</orcidid><orcidid>https://orcid.org/0000-0002-9374-0811</orcidid><orcidid>https://orcid.org/0000-0003-0640-0550</orcidid><orcidid>https://orcid.org/0000-0001-8096-4659</orcidid><orcidid>https://orcid.org/0000-0002-1402-5167</orcidid><orcidid>https://orcid.org/0000-0003-3580-0967</orcidid></search><sort><creationdate>20200101</creationdate><title>Smell and Taste Dysfunction in COVID-19 Is Associated With Younger Age in Ambulatory Settings: A Multicenter Cross-Sectional Study</title><author>Izquierdo-Dominguez, A. ; Rojas-Lechuga, M. J. ; Chiesa-Estomba, C. ; Calvo-Henriquez, C. ; Ninchritz-Becerra, E. ; Soriano-Reixach, M. ; Poletti-Serafini, D. ; Villarreal, I. M. ; Maza-Solano, J. M. ; Moreno-Luna, R. ; Villarroel, P. P. ; Mateos-Serrano, B. ; Agudelo, D. ; Valcarcel, F. ; del Cuvillo, A. ; Santamaria, A. ; Marino-Sanchez, F. ; Aguilar, J. ; Verges, P. ; Inciarte, A. ; Soriano, A. ; Mullol, J. ; Alobid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-6ac538e74533be81583be09009982fe4acc4a287679ff82c609bbc41c0b358103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Allergy</topic><topic>Betacoronavirus - genetics</topic><topic>Betacoronavirus - immunology</topic><topic>C-reactive protein</topic><topic>Case-Control Studies</topic><topic>Chemoreception</topic><topic>Coronavirus Infections - complications</topic><topic>Coronavirus Infections - diagnosis</topic><topic>Coronavirus Infections - epidemiology</topic><topic>Coronavirus Infections - virology</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Immunology</topic><topic>Life Sciences & Biomedicine</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>Olfaction</topic><topic>Olfaction Disorders - diagnosis</topic><topic>Olfaction Disorders - epidemiology</topic><topic>Olfaction Disorders - etiology</topic><topic>Pandemics</topic><topic>Patients</topic><topic>Pneumonia, Viral - complications</topic><topic>Pneumonia, Viral - diagnosis</topic><topic>Pneumonia, Viral - epidemiology</topic><topic>Pneumonia, Viral - virology</topic><topic>Polymerase Chain Reaction</topic><topic>Public Health Surveillance</topic><topic>SARS-CoV-2</topic><topic>Science & Technology</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Severity of Illness Index</topic><topic>Spain - epidemiology</topic><topic>Symptom Assessment</topic><topic>Taste</topic><topic>Taste Disorders - diagnosis</topic><topic>Taste Disorders - epidemiology</topic><topic>Taste Disorders - etiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Izquierdo-Dominguez, A.</creatorcontrib><creatorcontrib>Rojas-Lechuga, M. J.</creatorcontrib><creatorcontrib>Chiesa-Estomba, C.</creatorcontrib><creatorcontrib>Calvo-Henriquez, C.</creatorcontrib><creatorcontrib>Ninchritz-Becerra, E.</creatorcontrib><creatorcontrib>Soriano-Reixach, M.</creatorcontrib><creatorcontrib>Poletti-Serafini, D.</creatorcontrib><creatorcontrib>Villarreal, I. M.</creatorcontrib><creatorcontrib>Maza-Solano, J. M.</creatorcontrib><creatorcontrib>Moreno-Luna, R.</creatorcontrib><creatorcontrib>Villarroel, P. P.</creatorcontrib><creatorcontrib>Mateos-Serrano, B.</creatorcontrib><creatorcontrib>Agudelo, D.</creatorcontrib><creatorcontrib>Valcarcel, F.</creatorcontrib><creatorcontrib>del Cuvillo, A.</creatorcontrib><creatorcontrib>Santamaria, A.</creatorcontrib><creatorcontrib>Marino-Sanchez, F.</creatorcontrib><creatorcontrib>Aguilar, J.</creatorcontrib><creatorcontrib>Verges, P.</creatorcontrib><creatorcontrib>Inciarte, A.</creatorcontrib><creatorcontrib>Soriano, A.</creatorcontrib><creatorcontrib>Mullol, J.</creatorcontrib><creatorcontrib>Alobid</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of investigational allergology & clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Izquierdo-Dominguez, A.</au><au>Rojas-Lechuga, M. J.</au><au>Chiesa-Estomba, C.</au><au>Calvo-Henriquez, C.</au><au>Ninchritz-Becerra, E.</au><au>Soriano-Reixach, M.</au><au>Poletti-Serafini, D.</au><au>Villarreal, I. M.</au><au>Maza-Solano, J. M.</au><au>Moreno-Luna, R.</au><au>Villarroel, P. P.</au><au>Mateos-Serrano, B.</au><au>Agudelo, D.</au><au>Valcarcel, F.</au><au>del Cuvillo, A.</au><au>Santamaria, A.</au><au>Marino-Sanchez, F.</au><au>Aguilar, J.</au><au>Verges, P.</au><au>Inciarte, A.</au><au>Soriano, A.</au><au>Mullol, J.</au><au>Alobid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Smell and Taste Dysfunction in COVID-19 Is Associated With Younger Age in Ambulatory Settings: A Multicenter Cross-Sectional Study</atitle><jtitle>Journal of investigational allergology & clinical immunology</jtitle><stitle>J INVEST ALLERG CLIN</stitle><addtitle>J Investig Allergol Clin Immunol</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>30</volume><issue>5</issue><spage>346</spage><epage>357</epage><pages>346-357</pages><issn>1018-9068</issn><eissn>1698-0808</eissn><abstract>Background: Since the initial anecdotal reports of coronavirus disease 2019 (COVID-19) from China, a growing number of studies have reported on smell and/or taste dysfunction (STD).
Objective:The aim of our study was to investigate the frequency and severity of STD in COVID-19 patients and to evaluate the association with demographic characteristics, hospital admission, symptoms, comorbidities, and blood biomarkers.
Methods: We performed a multicenter cross-sectional study on patients who were positive for SARS-CoV-2 (n=846) and controls (n=143) from 15 Spanish hospitals. Data on STD were collected prospectively using an in-person survey. The severity of STD was categorized using a visual analog scale. We analyzed time to onset recovery rate, time to recovery, hospital admission, pneumonia, comorbidities, smoking, and symptoms.
Results: STD was at least 2-fold more common in COVID-19-positive patients than in controls. COVID-19-positive hospitalized patients were older, with a lower frequency of STD, and recovered earlier than outpatients. Analysis stratified by severity of STD showed that more than half of COVID-19 patients presented severe loss of smell (53.7%) or taste (52.2%); both senses were impaired in >90%. In the multivariate analysis, older age (>60 years), being hospitalized, and increased C-reactive protein were associated with a better sense of smell and/or taste. COVID-19-positive patients reported improvement in smell (45.6%) and taste (46.1%) at the time of the survey; in 90.6% this was within 2 weeks of infection.
Conclusion: STD is a common symptom in COVID-19 and presents mainly in young and nonhospitalized patients. More studies are needed to evaluate follow-up of chemosensory impairment.</abstract><cop>BARCELONA</cop><pub>Esmon Publicidad S A, Dept Allergy & Clin Immunol, Clin Univ Navarra</pub><pmid>32554337</pmid><doi>10.18176/jiaci.0595</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-1896-3457</orcidid><orcidid>https://orcid.org/0000-0002-3588-9095</orcidid><orcidid>https://orcid.org/0000-0002-9374-0811</orcidid><orcidid>https://orcid.org/0000-0003-0640-0550</orcidid><orcidid>https://orcid.org/0000-0001-8096-4659</orcidid><orcidid>https://orcid.org/0000-0002-1402-5167</orcidid><orcidid>https://orcid.org/0000-0003-3580-0967</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1018-9068 |
| ispartof | Journal of investigational allergology & clinical immunology, 2020-01, Vol.30 (5), p.346-357 |
| issn | 1018-9068 1698-0808 |
| language | eng |
| recordid | cdi_webofscience_primary_000579354400006 |
| source | MEDLINE; Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Age Factors Aged Aged, 80 and over Allergy Betacoronavirus - genetics Betacoronavirus - immunology C-reactive protein Case-Control Studies Chemoreception Coronavirus Infections - complications Coronavirus Infections - diagnosis Coronavirus Infections - epidemiology Coronavirus Infections - virology Coronaviruses COVID-19 Cross-Sectional Studies Female Hospitalization Humans Immunology Life Sciences & Biomedicine Male Middle Aged Multivariate analysis Olfaction Olfaction Disorders - diagnosis Olfaction Disorders - epidemiology Olfaction Disorders - etiology Pandemics Patients Pneumonia, Viral - complications Pneumonia, Viral - diagnosis Pneumonia, Viral - epidemiology Pneumonia, Viral - virology Polymerase Chain Reaction Public Health Surveillance SARS-CoV-2 Science & Technology Severe acute respiratory syndrome coronavirus 2 Severity of Illness Index Spain - epidemiology Symptom Assessment Taste Taste Disorders - diagnosis Taste Disorders - epidemiology Taste Disorders - etiology Young Adult |
| title | Smell and Taste Dysfunction in COVID-19 Is Associated With Younger Age in Ambulatory Settings: A Multicenter Cross-Sectional Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-11-29T10%3A35%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_webof&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Smell%20and%20Taste%20Dysfunction%20in%20COVID-19%20Is%20Associated%20With%20Younger%20Age%20in%20Ambulatory%20Settings:%20A%20Multicenter%20Cross-Sectional%20Study&rft.jtitle=Journal%20of%20investigational%20allergology%20&%20clinical%20immunology&rft.au=Izquierdo-Dominguez,%20A.&rft.date=2020-01-01&rft.volume=30&rft.issue=5&rft.spage=346&rft.epage=357&rft.pages=346-357&rft.issn=1018-9068&rft.eissn=1698-0808&rft_id=info:doi/10.18176/jiaci.0595&rft_dat=%3Cproquest_webof%3E2415297710%3C/proquest_webof%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2451553904&rft_id=info:pmid/32554337&rfr_iscdi=true |