Cell-based high-throughput screening of cationic polymers for efficient DNA and siRNA delivery

Development of non-viral gene vectors which can efficiently and safely transfect plasmid DNA and siRNA into cells is of great importance for gene therapy. Despite lots of efforts spent, it is still imperative to develop suitable gene vectors with better transfection efficiency and low cytotoxicity....

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Veröffentlicht in:	Acta biomaterialia 2020-10, Vol.115, p.410-417
Hauptverfasser:	Wu, Yihang, Wang, Ling, Xiong, Yue, Zhou, Quanming, Li, Linxian, Chen, Guanyu, Ping, Yulei, Davidson, Gary, Levkin, Pavel A., Gao, Liqian, Deng, Wenbin
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines Cationic polymerization Combinatorial library Cytotoxicity Deoxyribonucleic acid DNA Efficiency Engineering Engineering, Biomedical Expression vectors Gene delivery Gene therapy High-throughput screening High-Throughput Screening Assays Humans Hydrophobicity Materials Science Materials Science, Biomaterials Non-viral vectors Plasmids Polymer Polymers Reagents RNA, Small Interfering Science & Technology Screening siRNA Substitution reactions Technology Toxicity Transfection Vectors (Biology) Zeta potential
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