Changes in Parameters of Oxidative Stress, Immunity, and Behavior in Endurance Athletes During a Preparation Period in Winter

ABSTRACTMichalickova, D, Minic, R, Kotur-Stevuljevic, J, Andjelkovic, M, Dikic, N, Kostic-Vucicevic, M, Slanar, O, and Djordjevic, B. Changes in parameters of oxidative stress, immunity, and behavior in endurance athletes during a preparation period in winter. J Strength Cond Res 34(10)2965–2973, 20...

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Veröffentlicht in:Journal of strength and conditioning research 2020-10, Vol.34 (10), p.2965-2973
Hauptverfasser: Michalickova, Danica, Minic, Rajna, Kotur-Stevuljevic, Jelena, Andjelkovic, Marija, Dikic, Nenad, Kostic-Vucicevic, Marija, Slanar, Ondrej, Djordjevic, Brizita
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container_end_page 2973
container_issue 10
container_start_page 2965
container_title Journal of strength and conditioning research
container_volume 34
creator Michalickova, Danica
Minic, Rajna
Kotur-Stevuljevic, Jelena
Andjelkovic, Marija
Dikic, Nenad
Kostic-Vucicevic, Marija
Slanar, Ondrej
Djordjevic, Brizita
description ABSTRACTMichalickova, D, Minic, R, Kotur-Stevuljevic, J, Andjelkovic, M, Dikic, N, Kostic-Vucicevic, M, Slanar, O, and Djordjevic, B. Changes in parameters of oxidative stress, immunity, and behavior in endurance athletes during a preparation period in winter. J Strength Cond Res 34(10)2965–2973, 2020—The current study monitored markers of immunological and oxidative status in 9 male elite endurance athletesV[Combining Dot Above]O2max68 ± 11 ml·kg·min, age24 ± 2.5 years, and training loads128 ± 21 metabolic equivalents-h·wk during a 3-month preparation period in winter (January–March). Self-rated state of moods evaluation (by Profile of Mood States questionnaire) was performed, and blood samples were collected at the beginning and end of the study. Spectrophotometric methods and enzyme-linked immunosorbent assay were used for parametersʼ determination. The level of concanavalin A (ConA)-stimulated interferon-γ (IFN-γ) from peripheral blood mononuclear cells (PBMCs) was increased (562 [147–852] vs. 1,097 [451–1842] pg·ml, p = 0.013). Also, the level of transforming growth factor-1 (TGF-β1) in serum was elevated (2.5 [1.4–5.1] vs. 7.2 [4.9–8.2] ng·ml, p = 0.015). There was no change in the level of peptidoglycan (PGN)-stimulated interleukin (IL)-10 from PBMCs. There were no significant changes in PBMCs proliferation/viability on stimulation with ConA and PGN during the study. No changes in superoxide dismutase, prooxidative-antioxidative balance, total oxidant status (TOS), and thiobarbituric acid reactive substances were observed along the study. Total antioxidant status (TAS) was increased (910 ± 174 vs. 1,090 ± 102 μmol·L, p = 0.018), and activity of paraoxonase (PON1) was decreased (523 ± 295 vs. 335 ± 183 U·L, p = 0.003) at the end of the study. Advanced oxidation protein products were increased (25 ± 7.9 vs. 42 ± 7.6 μmol·L, p = 0.011). The self-rated sense of vigor significantly declined (20 ± 2.1 vs. 14 ± 3.4, p = 0.045). In conclusion, 3 months of regular training in winter induced prominent changes in cytokines, biomarkers of oxidative stress, and antioxidative enzyme activity. These changes might increase susceptibility of athletes to disease and muscle damage and consequently lead to performance reduction.
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Changes in parameters of oxidative stress, immunity, and behavior in endurance athletes during a preparation period in winter. J Strength Cond Res 34(10)2965–2973, 2020—The current study monitored markers of immunological and oxidative status in 9 male elite endurance athletesV[Combining Dot Above]O2max68 ± 11 ml·kg·min, age24 ± 2.5 years, and training loads128 ± 21 metabolic equivalents-h·wk during a 3-month preparation period in winter (January–March). Self-rated state of moods evaluation (by Profile of Mood States questionnaire) was performed, and blood samples were collected at the beginning and end of the study. Spectrophotometric methods and enzyme-linked immunosorbent assay were used for parametersʼ determination. The level of concanavalin A (ConA)-stimulated interferon-γ (IFN-γ) from peripheral blood mononuclear cells (PBMCs) was increased (562 [147–852] vs. 1,097 [451–1842] pg·ml, p = 0.013). Also, the level of transforming growth factor-1 (TGF-β1) in serum was elevated (2.5 [1.4–5.1] vs. 7.2 [4.9–8.2] ng·ml, p = 0.015). There was no change in the level of peptidoglycan (PGN)-stimulated interleukin (IL)-10 from PBMCs. There were no significant changes in PBMCs proliferation/viability on stimulation with ConA and PGN during the study. No changes in superoxide dismutase, prooxidative-antioxidative balance, total oxidant status (TOS), and thiobarbituric acid reactive substances were observed along the study. Total antioxidant status (TAS) was increased (910 ± 174 vs. 1,090 ± 102 μmol·L, p = 0.018), and activity of paraoxonase (PON1) was decreased (523 ± 295 vs. 335 ± 183 U·L, p = 0.003) at the end of the study. Advanced oxidation protein products were increased (25 ± 7.9 vs. 42 ± 7.6 μmol·L, p = 0.011). The self-rated sense of vigor significantly declined (20 ± 2.1 vs. 14 ± 3.4, p = 0.045). In conclusion, 3 months of regular training in winter induced prominent changes in cytokines, biomarkers of oxidative stress, and antioxidative enzyme activity. These changes might increase susceptibility of athletes to disease and muscle damage and consequently lead to performance reduction.</description><identifier>ISSN: 1064-8011</identifier><identifier>EISSN: 1533-4287</identifier><identifier>DOI: 10.1519/JSC.0000000000002780</identifier><identifier>PMID: 30199454</identifier><language>eng</language><publisher>PHILADELPHIA: Journal of Strength and Conditioning Research</publisher><subject>Adolescent ; Adult ; Affect - physiology ; Antioxidants ; Athletes ; Biomarkers ; Concanavalin A ; Cytokines - metabolism ; Endurance ; Enzymatic activity ; Enzyme-Linked Immunosorbent Assay ; Exercise Test ; Humans ; Immunity ; Immunology ; Leukocytes (mononuclear) ; Leukocytes, Mononuclear - metabolism ; Life Sciences &amp; Biomedicine ; Longitudinal Studies ; Male ; Metabolic Equivalent - physiology ; Mood ; Nutritional Status ; Oxidants ; Oxidation-Reduction ; Oxidative stress ; Oxidative Stress - physiology ; Oxygen Consumption - physiology ; Paraoxonase ; Peptidoglycans ; Peripheral blood mononuclear cells ; Physical Endurance - immunology ; Physical Endurance - physiology ; Physical fitness ; Science &amp; Technology ; Spectrophotometry ; Sport Sciences ; Superoxide dismutase ; Thiobarbituric acid ; Transforming growth factor-b1 ; Winter ; Young Adult ; γ-Interferon</subject><ispartof>Journal of strength and conditioning research, 2020-10, Vol.34 (10), p.2965-2973</ispartof><rights>Journal of Strength and Conditioning Research</rights><rights>Copyright © 2020 by the National Strength &amp; Conditioning Association.</rights><rights>Copyright Lippincott Williams &amp; Wilkins Ovid Technologies Oct 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>5</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000575992200033</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c4290-1d68aec128db85f1fc80ab4e2c8f24914889eb5330c19aa1de2c1408f1baab53</citedby><cites>FETCH-LOGICAL-c4290-1d68aec128db85f1fc80ab4e2c8f24914889eb5330c19aa1de2c1408f1baab53</cites><orcidid>0000-0002-9690-9846 ; 0000-0002-5357-7562</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930,28253</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30199454$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Michalickova, Danica</creatorcontrib><creatorcontrib>Minic, Rajna</creatorcontrib><creatorcontrib>Kotur-Stevuljevic, Jelena</creatorcontrib><creatorcontrib>Andjelkovic, Marija</creatorcontrib><creatorcontrib>Dikic, Nenad</creatorcontrib><creatorcontrib>Kostic-Vucicevic, Marija</creatorcontrib><creatorcontrib>Slanar, Ondrej</creatorcontrib><creatorcontrib>Djordjevic, Brizita</creatorcontrib><title>Changes in Parameters of Oxidative Stress, Immunity, and Behavior in Endurance Athletes During a Preparation Period in Winter</title><title>Journal of strength and conditioning research</title><addtitle>J STRENGTH COND RES</addtitle><addtitle>J Strength Cond Res</addtitle><description>ABSTRACTMichalickova, D, Minic, R, Kotur-Stevuljevic, J, Andjelkovic, M, Dikic, N, Kostic-Vucicevic, M, Slanar, O, and Djordjevic, B. Changes in parameters of oxidative stress, immunity, and behavior in endurance athletes during a preparation period in winter. J Strength Cond Res 34(10)2965–2973, 2020—The current study monitored markers of immunological and oxidative status in 9 male elite endurance athletesV[Combining Dot Above]O2max68 ± 11 ml·kg·min, age24 ± 2.5 years, and training loads128 ± 21 metabolic equivalents-h·wk during a 3-month preparation period in winter (January–March). Self-rated state of moods evaluation (by Profile of Mood States questionnaire) was performed, and blood samples were collected at the beginning and end of the study. Spectrophotometric methods and enzyme-linked immunosorbent assay were used for parametersʼ determination. The level of concanavalin A (ConA)-stimulated interferon-γ (IFN-γ) from peripheral blood mononuclear cells (PBMCs) was increased (562 [147–852] vs. 1,097 [451–1842] pg·ml, p = 0.013). Also, the level of transforming growth factor-1 (TGF-β1) in serum was elevated (2.5 [1.4–5.1] vs. 7.2 [4.9–8.2] ng·ml, p = 0.015). There was no change in the level of peptidoglycan (PGN)-stimulated interleukin (IL)-10 from PBMCs. There were no significant changes in PBMCs proliferation/viability on stimulation with ConA and PGN during the study. No changes in superoxide dismutase, prooxidative-antioxidative balance, total oxidant status (TOS), and thiobarbituric acid reactive substances were observed along the study. Total antioxidant status (TAS) was increased (910 ± 174 vs. 1,090 ± 102 μmol·L, p = 0.018), and activity of paraoxonase (PON1) was decreased (523 ± 295 vs. 335 ± 183 U·L, p = 0.003) at the end of the study. Advanced oxidation protein products were increased (25 ± 7.9 vs. 42 ± 7.6 μmol·L, p = 0.011). The self-rated sense of vigor significantly declined (20 ± 2.1 vs. 14 ± 3.4, p = 0.045). In conclusion, 3 months of regular training in winter induced prominent changes in cytokines, biomarkers of oxidative stress, and antioxidative enzyme activity. These changes might increase susceptibility of athletes to disease and muscle damage and consequently lead to performance reduction.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Affect - physiology</subject><subject>Antioxidants</subject><subject>Athletes</subject><subject>Biomarkers</subject><subject>Concanavalin A</subject><subject>Cytokines - metabolism</subject><subject>Endurance</subject><subject>Enzymatic activity</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Exercise Test</subject><subject>Humans</subject><subject>Immunity</subject><subject>Immunology</subject><subject>Leukocytes (mononuclear)</subject><subject>Leukocytes, Mononuclear - metabolism</subject><subject>Life Sciences &amp; Biomedicine</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Metabolic Equivalent - physiology</subject><subject>Mood</subject><subject>Nutritional Status</subject><subject>Oxidants</subject><subject>Oxidation-Reduction</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - physiology</subject><subject>Oxygen Consumption - physiology</subject><subject>Paraoxonase</subject><subject>Peptidoglycans</subject><subject>Peripheral blood mononuclear cells</subject><subject>Physical Endurance - immunology</subject><subject>Physical Endurance - physiology</subject><subject>Physical fitness</subject><subject>Science &amp; Technology</subject><subject>Spectrophotometry</subject><subject>Sport Sciences</subject><subject>Superoxide dismutase</subject><subject>Thiobarbituric acid</subject><subject>Transforming growth factor-b1</subject><subject>Winter</subject><subject>Young Adult</subject><subject>γ-Interferon</subject><issn>1064-8011</issn><issn>1533-4287</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><recordid>eNqNkUtv1TAQhSMEog_4BwhZYoPUpnj8uNdellCgqFIrtRLLyEkmvS6JfbGdli747zjcUlVdAN7Ysr9zxjOnKF4BPQAJ-t2X8-qAPlhsqeiTYhsk56Vgavk0n-lClIoCbBU7MV5lRkrJnxdbnILWQort4me1Mu4SI7GOnJlgRkwYIvE9Of1hO5PsNZLzFDDGfXI8jpOz6XafGNeR97gy19aHWXnkuikY1yI5TKshW0TyYQrWXRJDzgKus3GyPlfAYH03K75alwu9KJ71Zoj48m7fLS4-Hl1Un8uT00_H1eFJ2QqmaQndQhlsgamuUbKHvlXUNAJZq3omNAilNDa5cdqCNga6_AKCqh4aY_L9bvF2Y7sO_vuEMdWjjS0Og3Hop1gzoIwzTukio28eoVd-Ci5_rmZCgpQLrnSmxIZqg48xYF-vgx1NuK2B1nM6dU6nfpxOlr2-M5-aEbt70Z84MqA2wA02vo-txTzTeyzbyKXUmrF84ryy6fdUKz-5lKV7_y99UMgPc-DfhukGQ71CM6TVv5oQf5FSCkxkrmSUUZhF5VwR-C_c-cum</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Michalickova, Danica</creator><creator>Minic, Rajna</creator><creator>Kotur-Stevuljevic, Jelena</creator><creator>Andjelkovic, Marija</creator><creator>Dikic, Nenad</creator><creator>Kostic-Vucicevic, Marija</creator><creator>Slanar, Ondrej</creator><creator>Djordjevic, Brizita</creator><general>Journal of Strength and Conditioning Research</general><general>Copyright by the National Strength &amp; Conditioning Association</general><general>Lippincott Williams &amp; Wilkins</general><general>Lippincott Williams &amp; Wilkins Ovid Technologies</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9690-9846</orcidid><orcidid>https://orcid.org/0000-0002-5357-7562</orcidid></search><sort><creationdate>20201001</creationdate><title>Changes in Parameters of Oxidative Stress, Immunity, and Behavior in Endurance Athletes During a Preparation Period in Winter</title><author>Michalickova, Danica ; Minic, Rajna ; Kotur-Stevuljevic, Jelena ; Andjelkovic, Marija ; Dikic, Nenad ; Kostic-Vucicevic, Marija ; Slanar, Ondrej ; Djordjevic, Brizita</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4290-1d68aec128db85f1fc80ab4e2c8f24914889eb5330c19aa1de2c1408f1baab53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Affect - physiology</topic><topic>Antioxidants</topic><topic>Athletes</topic><topic>Biomarkers</topic><topic>Concanavalin A</topic><topic>Cytokines - metabolism</topic><topic>Endurance</topic><topic>Enzymatic activity</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Exercise Test</topic><topic>Humans</topic><topic>Immunity</topic><topic>Immunology</topic><topic>Leukocytes (mononuclear)</topic><topic>Leukocytes, Mononuclear - metabolism</topic><topic>Life Sciences &amp; 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Changes in parameters of oxidative stress, immunity, and behavior in endurance athletes during a preparation period in winter. J Strength Cond Res 34(10)2965–2973, 2020—The current study monitored markers of immunological and oxidative status in 9 male elite endurance athletesV[Combining Dot Above]O2max68 ± 11 ml·kg·min, age24 ± 2.5 years, and training loads128 ± 21 metabolic equivalents-h·wk during a 3-month preparation period in winter (January–March). Self-rated state of moods evaluation (by Profile of Mood States questionnaire) was performed, and blood samples were collected at the beginning and end of the study. Spectrophotometric methods and enzyme-linked immunosorbent assay were used for parametersʼ determination. The level of concanavalin A (ConA)-stimulated interferon-γ (IFN-γ) from peripheral blood mononuclear cells (PBMCs) was increased (562 [147–852] vs. 1,097 [451–1842] pg·ml, p = 0.013). Also, the level of transforming growth factor-1 (TGF-β1) in serum was elevated (2.5 [1.4–5.1] vs. 7.2 [4.9–8.2] ng·ml, p = 0.015). There was no change in the level of peptidoglycan (PGN)-stimulated interleukin (IL)-10 from PBMCs. There were no significant changes in PBMCs proliferation/viability on stimulation with ConA and PGN during the study. No changes in superoxide dismutase, prooxidative-antioxidative balance, total oxidant status (TOS), and thiobarbituric acid reactive substances were observed along the study. Total antioxidant status (TAS) was increased (910 ± 174 vs. 1,090 ± 102 μmol·L, p = 0.018), and activity of paraoxonase (PON1) was decreased (523 ± 295 vs. 335 ± 183 U·L, p = 0.003) at the end of the study. Advanced oxidation protein products were increased (25 ± 7.9 vs. 42 ± 7.6 μmol·L, p = 0.011). The self-rated sense of vigor significantly declined (20 ± 2.1 vs. 14 ± 3.4, p = 0.045). In conclusion, 3 months of regular training in winter induced prominent changes in cytokines, biomarkers of oxidative stress, and antioxidative enzyme activity. These changes might increase susceptibility of athletes to disease and muscle damage and consequently lead to performance reduction.</abstract><cop>PHILADELPHIA</cop><pub>Journal of Strength and Conditioning Research</pub><pmid>30199454</pmid><doi>10.1519/JSC.0000000000002780</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-9690-9846</orcidid><orcidid>https://orcid.org/0000-0002-5357-7562</orcidid></addata></record>
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subjects Adolescent
Adult
Affect - physiology
Antioxidants
Athletes
Biomarkers
Concanavalin A
Cytokines - metabolism
Endurance
Enzymatic activity
Enzyme-Linked Immunosorbent Assay
Exercise Test
Humans
Immunity
Immunology
Leukocytes (mononuclear)
Leukocytes, Mononuclear - metabolism
Life Sciences & Biomedicine
Longitudinal Studies
Male
Metabolic Equivalent - physiology
Mood
Nutritional Status
Oxidants
Oxidation-Reduction
Oxidative stress
Oxidative Stress - physiology
Oxygen Consumption - physiology
Paraoxonase
Peptidoglycans
Peripheral blood mononuclear cells
Physical Endurance - immunology
Physical Endurance - physiology
Physical fitness
Science & Technology
Spectrophotometry
Sport Sciences
Superoxide dismutase
Thiobarbituric acid
Transforming growth factor-b1
Winter
Young Adult
γ-Interferon
title Changes in Parameters of Oxidative Stress, Immunity, and Behavior in Endurance Athletes During a Preparation Period in Winter
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