Effects of administration of ascorbic acid and low‐dose hydrocortisone after infusion of sublethal doses of lipopolysaccharide to horses

Background Sepsis is associated with ascorbic acid (AA) depletion and critical illness‐related corticosteroid insufficiency (CIRCI) in humans. Hypotheses Intravenous infusion of lipopolysaccharide (LPS) would (a) decrease endogneous AA concentrations, (b) induce CIRCI and (c) administration of a com...

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Veröffentlicht in:	Journal of veterinary internal medicine 2020-11, Vol.34 (6), p.2710-2718
Hauptverfasser:	Anderson, Melinda J., Ibrahim, Alina S., Cooper, Bruce R., Woolcock, Andrew D., Moore, George E., Taylor, Sandra D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animals Ascorbic Acid - therapeutic use Blood pressure Catheters Chloride corticosteroid Cytokines Cytokines - genetics Drug dosages endotoxemia Endotoxemia - drug therapy Endotoxemia - veterinary Enzymes EQUINE Gene expression Hormones Horse Diseases - chemically induced Horse Diseases - drug therapy Horses Hydrocortisone - therapeutic use Illnesses Infections Lipopolysaccharides Neutrophils Nitric oxide Pain Sepsis Steroids Tumor necrosis factor-TNF Vitamin C
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