Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit

We tested the proposal that the C-terminal domain (CTD) of the AMPAR subunit GluA1 is required for LTP. We found that a knock-in mouse lacking the CTD of GluA1 expresses normal LTP and spatial memory, assayed by the Morris water maze. Our results support a model in which LTP generates synaptic slots...

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Veröffentlicht in:	eLife 2020-08, Vol.9
Hauptverfasser:	Díaz-Alonso, Javier, Morishita, Wade, Incontro, Salvatore, Simms, Jeffrey, Holtzman, Julia, Gill, Michael, Mucke, Lennart, Malenka, Robert C, Nicoll, Roger A
Format:	Artikel
Sprache:	eng
Schlagworte:	AMPA receptor Animals Cell Line Cell receptors Female Gene Knock-In Techniques hippocampus Hippocampus - metabolism Humans Long-term potentiation Long-Term Potentiation - genetics Long-Term Potentiation - physiology Male Maze Learning - physiology memory formation Mice Mice, Inbred C57BL Mice, Transgenic Neuroscience Observations Physiological aspects Protein Domains - genetics Receptors, AMPA - chemistry Receptors, AMPA - genetics Receptors, AMPA - metabolism spatial learning Spatial Memory - physiology synaptic plasticity
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Beschreibung
Zusammenfassung:	We tested the proposal that the C-terminal domain (CTD) of the AMPAR subunit GluA1 is required for LTP. We found that a knock-in mouse lacking the CTD of GluA1 expresses normal LTP and spatial memory, assayed by the Morris water maze. Our results support a model in which LTP generates synaptic slots, which capture passively diffusing AMPARs.
ISSN:	2050-084X 2050-084X
DOI:	10.7554/eLife.58042