Roles of Pyk2 in signal transduction after gonadotropin‐releasing hormone receptor stimulation

The receptor for gonadotropin‐releasing hormone (GnRH) is highly expressed in hypothalamic neurons. It has been reported that GnRH treatment of cultured GnRH neurons (GT1‐7 cells) activated proline‐rich tyrosine kinase 2 (Pyk2), and Pyk2 was involved in the activation of extracellular signal‐regulat...

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Veröffentlicht in:	Journal of cellular physiology 2021-04, Vol.236 (4), p.3033-3043
Hauptverfasser:	Okitsu‐Sakurayama, Shiho, Higa‐Nakamine, Sayomi, Torihara, Hidetsugu, Higashiyama, Shigeki, Yamamoto, Hideyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Anticoagulants Cell Biology Epidermal growth factor Epidermal growth factor receptors Extracellular signal-regulated kinase Flags Gonadotropin-releasing hormone Gonadotropins GRB2 protein Growth factors Heparin heparin‐binding EGF‐like growth factor Hypothalamus Kinases Life Sciences & Biomedicine mitogen‐activated protein kinase 1 mitogen‐activated protein kinase 3 Neurons Phenylalanine Physiology Pituitary (anterior) Proline Protein-tyrosine kinase Proteins PTK2B protein Raf protein Receptors Science & Technology Signal transduction siRNA Tyrosine
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