Fatty Acid Profile and Metabolism Are Related to Human Sperm Parameters and Are Relevant in Idiopathic Infertility and Varicocele

Objectives. Fatty acids (FA) modulate oxidative stress, reactive oxygen species (ROS) production, and inflammatory processes in spermatogenesis. Methods. The amount of 17 different FAs and the level of F2-isoprostanes (F2-IsoPs) and cytoplasmic phospholipase A2 (cPLA2) were compared and correlated t...

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Veröffentlicht in:	Mediators of inflammation 2020, Vol.2020 (2020), p.1-13
Hauptverfasser:	Iacoponi, Francesca, Noto, Daria, Moretti, Elena, Collodel, Giulia, Signorini, Cinzia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Apoptosis Docosahexaenoic acid Docosahexaenoic Acids - metabolism Eicosapentaenoic acid F2-Isoprostanes - metabolism Fatty acids Fatty Acids - metabolism Fertility Free radicals Humans Infertility Infertility, Male - metabolism Inflammation Isoprostanes Lipid peroxidation Lipids Male Metabolism Microscopy, Electron, Transmission Morphology Motility Necrosis Oleic acid Oxidation Oxidative stress Palmitoleic acid Phospholipase A2 Phospholipases A2 - metabolism Polyunsaturated fatty acids Population studies Reactive oxygen species Sperm Spermatogenesis Spermatozoa - metabolism Transmission electron microscopy Varicocele - metabolism
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Zusammenfassung:	Objectives. Fatty acids (FA) modulate oxidative stress, reactive oxygen species (ROS) production, and inflammatory processes in spermatogenesis. Methods. The amount of 17 different FAs and the level of F2-isoprostanes (F2-IsoPs) and cytoplasmic phospholipase A2 (cPLA2) were compared and correlated to sperm characteristics; these last ones were evaluated by light and electronic microscopy in varicocele and idiopathic infertile patients. Results. Total n-3 polyunsaturated acids (PUFAs) and docosahexaenoic acid (DHA), one of the n-3 PUFAs, were significantly reduced in idiopathic infertile men compared to controls (P
ISSN:	0962-9351 1466-1861
DOI:	10.1155/2020/3640450