Pharmacokinetic and pharmacodynamic analysis of neutropenia following nab-paclitaxel administration in Japanese patients with metastatic solid cancer

Purpose To develop a pharmacokinetic (PK) and pharmacodynamic (PD) model for neutropenia following nab-paclitaxel administration and identify factors associated with drug disposition and changes in neutrophil counts in patients with solid cancer. Methods PK/PD analysis by nonlinear mixed effects app...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2020-10, Vol.86 (4), p.487-495
Hauptverfasser:	Tsushima, Takahiro, Kasai, Hidefumi, Tanigawara, Yusuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Albumins - administration & dosage Albumins - adverse effects Albumins - pharmacokinetics Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - adverse effects Antineoplastic Agents, Phytogenic - pharmacokinetics Cancer Research Clinical Trials, Phase I as Topic Computer Simulation Dose-Response Relationship, Drug Drug Administration Schedule Female Humans Japan - epidemiology Leukocyte Count Life Sciences & Biomedicine Male Medicine Medicine & Public Health Middle Aged Models, Biological Neoplasms - blood Neoplasms - drug therapy Neoplasms - pathology Neutropenia - blood Neutropenia - chemically induced Neutropenia - diagnosis Neutropenia - epidemiology Neutrophils Oncology Original Article Paclitaxel - administration & dosage Paclitaxel - adverse effects Paclitaxel - pharmacokinetics Pharmacology & Pharmacy Pharmacology/Toxicology Risk Factors Science & Technology
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