Validation of a Homogeneous Incremental Centrifugal Liquid Sedimentation Method for Size Analysis of Silica (Nano)particles

Silica nanoparticles display many unique physicochemical properties that make them desirable for use in a wide variety of consumer products and composite materials. Accurately measuring the size of these nanoparticles is important for achieving the desired nanoscale functionality of the final product and for regulatory compliances. This study covers the validation of a centrifugal liquid sedimentation method for accurate measurement of the Stokes diameter of silica particles with a near-spherical shape and dimensions in the nanometer and sub-nanometer scale range. The validated method provided unbiased results in the range of 50 nm to 200 nm, with a lower limit of detection of