Type 5 phosphodiesterase (PDE5) and the vascular tree: From embryogenesis to aging and disease
•Vascular development depends on the timely differentiation of endothelial and smooth muscle cells.•Vascular aging and vascular disease are influenced by endothelial and vascular smooth muscle cell compartments.•A survey of the literature on the role of PDE5 in vascular development, aging and diseas...
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| Veröffentlicht in: | Mechanisms of ageing and development 2020-09, Vol.190, p.111311-111311, Article 111311 |
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| container_title | Mechanisms of ageing and development |
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| creator | Cesarini, Valeriana Guida, Eugenia Campolo, Federica Crescioli, Clara Di Baldassarre, Angela Pisano, Calogera Balistreri, Carmela Rita Ruvolo, Giovanni Jannini, Emmanuele A. Dolci, Susanna |
| description | •Vascular development depends on the timely differentiation of endothelial and smooth muscle cells.•Vascular aging and vascular disease are influenced by endothelial and vascular smooth muscle cell compartments.•A survey of the literature on the role of PDE5 in vascular development, aging and disease is reported.•The role of PDE5 on vascular development, aging and disease needs to be further investigated by its genetic ablation.
Vascular tree development depends on the timely differentiation of endothelial and vascular smooth muscle cells. These latter are key players in the formation of the vascular scaffold that offers resistance to the blood flow. This review aims at providing an overview on the role of PDE5, the cGMP-specific phosphodiesterase that historically attracted much attention for its involvement in male impotence, in the regulation of vascular smooth muscle cell function. The overall goal is to underscore the importance of PDE5 expression and activity in this cell type in the context of the organs where its function has been extensively studied. |
| doi_str_mv | 10.1016/j.mad.2020.111311 |
| format | Article |
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Vascular tree development depends on the timely differentiation of endothelial and vascular smooth muscle cells. These latter are key players in the formation of the vascular scaffold that offers resistance to the blood flow. This review aims at providing an overview on the role of PDE5, the cGMP-specific phosphodiesterase that historically attracted much attention for its involvement in male impotence, in the regulation of vascular smooth muscle cell function. The overall goal is to underscore the importance of PDE5 expression and activity in this cell type in the context of the organs where its function has been extensively studied.</description><identifier>ISSN: 0047-6374</identifier><identifier>EISSN: 1872-6216</identifier><identifier>DOI: 10.1016/j.mad.2020.111311</identifier><identifier>PMID: 32628940</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>cGMP ; ECs ; Nitric oxide ; PDE5 ; VSMCs</subject><ispartof>Mechanisms of ageing and development, 2020-09, Vol.190, p.111311-111311, Article 111311</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><rights>2020 Elsevier B.V. All rights reserved. 2020 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-d9825cd3670bc7f26561ad6c2531f90f3d1cf278feb2359b7e2f6091f28efa903</citedby><cites>FETCH-LOGICAL-c451t-d9825cd3670bc7f26561ad6c2531f90f3d1cf278feb2359b7e2f6091f28efa903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.mad.2020.111311$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,315,781,785,886,3551,27926,27927,45997</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32628940$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cesarini, Valeriana</creatorcontrib><creatorcontrib>Guida, Eugenia</creatorcontrib><creatorcontrib>Campolo, Federica</creatorcontrib><creatorcontrib>Crescioli, Clara</creatorcontrib><creatorcontrib>Di Baldassarre, Angela</creatorcontrib><creatorcontrib>Pisano, Calogera</creatorcontrib><creatorcontrib>Balistreri, Carmela Rita</creatorcontrib><creatorcontrib>Ruvolo, Giovanni</creatorcontrib><creatorcontrib>Jannini, Emmanuele A.</creatorcontrib><creatorcontrib>Dolci, Susanna</creatorcontrib><title>Type 5 phosphodiesterase (PDE5) and the vascular tree: From embryogenesis to aging and disease</title><title>Mechanisms of ageing and development</title><addtitle>Mech Ageing Dev</addtitle><description>•Vascular development depends on the timely differentiation of endothelial and smooth muscle cells.•Vascular aging and vascular disease are influenced by endothelial and vascular smooth muscle cell compartments.•A survey of the literature on the role of PDE5 in vascular development, aging and disease is reported.•The role of PDE5 on vascular development, aging and disease needs to be further investigated by its genetic ablation.
Vascular tree development depends on the timely differentiation of endothelial and vascular smooth muscle cells. These latter are key players in the formation of the vascular scaffold that offers resistance to the blood flow. This review aims at providing an overview on the role of PDE5, the cGMP-specific phosphodiesterase that historically attracted much attention for its involvement in male impotence, in the regulation of vascular smooth muscle cell function. The overall goal is to underscore the importance of PDE5 expression and activity in this cell type in the context of the organs where its function has been extensively studied.</description><subject>cGMP</subject><subject>ECs</subject><subject>Nitric oxide</subject><subject>PDE5</subject><subject>VSMCs</subject><issn>0047-6374</issn><issn>1872-6216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kUFrFDEYhoModq3-AC-SYz3Mmu_LTGZGQZDaqlDQQ70aMsmX3Sw7kzWZXdh_b-rWohcPIYS875PwPYy9BLEEAerNZjkat0SB5QwgAR6xBXQtVgpBPWYLIeq2UrKtz9iznDdCCKhRPWVnEhV2fS0W7MftcUe84bt1zGW5QHmmZDLxi28fr5rX3EyOz2viB5PtfmsSnxPRW36d4shpHNIxrmiiHDKfIzerMK1-V1zIVCjP2RNvtple3O_n7Pv11e3l5-rm66cvlx9uKls3MFeu77CxTqpWDLb1qBoFximLjQTfCy8dWI9t52lA2fRDS-iV6MFjR970Qp6z9yfubj-M5CxNczJbvUthNOmoown635sprPUqHnQrpVQgC-DiHpDiz30Zgh5DtrTdmoniPmusEQCxw75E4RS1KeacyD88A0LfedEbXbzoOy_65KV0Xv39v4fGHxEl8O4UoDKlQ6Cksw00WXIhkZ21i-E_-F-kA533</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Cesarini, Valeriana</creator><creator>Guida, Eugenia</creator><creator>Campolo, Federica</creator><creator>Crescioli, Clara</creator><creator>Di Baldassarre, Angela</creator><creator>Pisano, Calogera</creator><creator>Balistreri, Carmela Rita</creator><creator>Ruvolo, Giovanni</creator><creator>Jannini, Emmanuele A.</creator><creator>Dolci, Susanna</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200901</creationdate><title>Type 5 phosphodiesterase (PDE5) and the vascular tree: From embryogenesis to aging and disease</title><author>Cesarini, Valeriana ; Guida, Eugenia ; Campolo, Federica ; Crescioli, Clara ; Di Baldassarre, Angela ; Pisano, Calogera ; Balistreri, Carmela Rita ; Ruvolo, Giovanni ; Jannini, Emmanuele A. ; Dolci, Susanna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-d9825cd3670bc7f26561ad6c2531f90f3d1cf278feb2359b7e2f6091f28efa903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>cGMP</topic><topic>ECs</topic><topic>Nitric oxide</topic><topic>PDE5</topic><topic>VSMCs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cesarini, Valeriana</creatorcontrib><creatorcontrib>Guida, Eugenia</creatorcontrib><creatorcontrib>Campolo, Federica</creatorcontrib><creatorcontrib>Crescioli, Clara</creatorcontrib><creatorcontrib>Di Baldassarre, Angela</creatorcontrib><creatorcontrib>Pisano, Calogera</creatorcontrib><creatorcontrib>Balistreri, Carmela Rita</creatorcontrib><creatorcontrib>Ruvolo, Giovanni</creatorcontrib><creatorcontrib>Jannini, Emmanuele A.</creatorcontrib><creatorcontrib>Dolci, Susanna</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Mechanisms of ageing and development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cesarini, Valeriana</au><au>Guida, Eugenia</au><au>Campolo, Federica</au><au>Crescioli, Clara</au><au>Di Baldassarre, Angela</au><au>Pisano, Calogera</au><au>Balistreri, Carmela Rita</au><au>Ruvolo, Giovanni</au><au>Jannini, Emmanuele A.</au><au>Dolci, Susanna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Type 5 phosphodiesterase (PDE5) and the vascular tree: From embryogenesis to aging and disease</atitle><jtitle>Mechanisms of ageing and development</jtitle><addtitle>Mech Ageing Dev</addtitle><date>2020-09-01</date><risdate>2020</risdate><volume>190</volume><spage>111311</spage><epage>111311</epage><pages>111311-111311</pages><artnum>111311</artnum><issn>0047-6374</issn><eissn>1872-6216</eissn><abstract>•Vascular development depends on the timely differentiation of endothelial and smooth muscle cells.•Vascular aging and vascular disease are influenced by endothelial and vascular smooth muscle cell compartments.•A survey of the literature on the role of PDE5 in vascular development, aging and disease is reported.•The role of PDE5 on vascular development, aging and disease needs to be further investigated by its genetic ablation.
Vascular tree development depends on the timely differentiation of endothelial and vascular smooth muscle cells. These latter are key players in the formation of the vascular scaffold that offers resistance to the blood flow. This review aims at providing an overview on the role of PDE5, the cGMP-specific phosphodiesterase that historically attracted much attention for its involvement in male impotence, in the regulation of vascular smooth muscle cell function. The overall goal is to underscore the importance of PDE5 expression and activity in this cell type in the context of the organs where its function has been extensively studied.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>32628940</pmid><doi>10.1016/j.mad.2020.111311</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Mechanisms of ageing and development, 2020-09, Vol.190, p.111311-111311, Article 111311 |
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| language | eng |
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| source | Access via ScienceDirect (Elsevier) |
| subjects | cGMP ECs Nitric oxide PDE5 VSMCs |
| title | Type 5 phosphodiesterase (PDE5) and the vascular tree: From embryogenesis to aging and disease |
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