Fabrication of chlorambucil loaded graphene- oxide nanocarrier and its application for improved antitumor activity

Schematic representation of chlorambucil drug loaded into folic acid functionalized gelatin-graphene oxide nanocomposite. [Display omitted] •Design of a nanocarrier using gelatin, reduced graphene oxide, folic acid and loaded with chlorambucil drug.•Highest encapsulation efficiency of 56% for rGO of...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2020-09, Vol.129, p.110443, Article 110443
Hauptverfasser:	Singh, Geetanjali, Nenavathu, Bhavani P., Imtiyaz, Khalid, Moshahid A Rizvi, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - pathology Antineoplastic Agents, Alkylating - chemistry Antineoplastic Agents, Alkylating - pharmacology Cell Line, Tumor Cell Survival - drug effects Chlorambucil - chemistry Chlorambucil - pharmacology Chlorambucil drug Delayed-Action Preparations Dose-Response Relationship, Drug Drug Carriers Drug Compounding Drug Liberation Female Folic acid Folic Acid - chemistry Gelatin - chemistry Graphene oxide Graphite - chemistry Humans Hydrogen-Ion Concentration Inhibitory Concentration 50 Kinetics Nanoparticles Targeted drug delivery Therapeutic effect Uterine Cervical Neoplasms - drug therapy Uterine Cervical Neoplasms - pathology
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