Polymorphisms within the RANK and RANKL Encoding Genes in Patients with Rheumatoid Arthritis: Association with Disease Progression and Effectiveness of the Biological Treatment

Inconsistency of the results regarding the genetic variability within genes coding for receptor activator of nuclear factor κB (RANK) and its ligand (RANKL) in rheumatoid arthritis (RA) prompted us to study the RANK and RANKL polymorphisms as potential biomarkers associated with disease predispositi...

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Veröffentlicht in:	Archivum Immunologiae et Therapiae Experimentalis 2020-08, Vol.68 (4), p.24-24, Article 24
Hauptverfasser:	Wielińska, Joanna, Kolossa, Katarzyna, Świerkot, Jerzy, Dratwa, Marta, Iwaszko, Milena, Bugaj, Bartosz, Wysoczańska, Barbara, Chaszczewska-Markowska, Monika, Jeka, Sławomir, Bogunia-Kubik, Katarzyna
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Alkaline phosphatase Alleles Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - therapy Biomedical and Life Sciences Biomedicine C-reactive protein Disease Progression Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Genetic variability Genotype Homozygotes Humans Immunology Immunotherapy - methods Joint diseases Life Sciences & Biomedicine Male Melting curve Middle Aged Original Original Article Patients Pharmacology/Toxicology Polymorphism, Single Nucleotide RANK Ligand - genetics Receptor Activator of Nuclear Factor-kappa B - genetics Rheumatoid arthritis Science & Technology Serum levels Single-nucleotide polymorphism TRANCE protein Treatment Outcome Tumor Necrosis Factor Inhibitors - therapeutic use
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