Predictive factors of progression to severe COVID-19

Predictive factors of progression to severe COVID-19

Early diagnosis and treatment are crucial for the survival of severe Coronavirus Disease 2019 (COVID-19) patients, but data with regard to risk factors for disease progression from milder COVID-19 to severe COVID-19 remain scarce. We conducted a retrospective analysis on 116 patients. Three factors...

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Veröffentlicht in:Open medicine (Warsaw, Poland) Poland), 2020-01, Vol.15 (1), p.805-814
Hauptverfasser: Zhou, Yi-Hong, Li, Huan, Qin, Yuan-Yuan, Yan, Xiao-Feng, Lu, Yan-Qiu, Liu, Hong-Lan, Ye, Si-Kuan, Wan, Yan, Zhang, Lu, Harypursat, Vijay, Chen, Yaokai
Format: Artikel
Sprache:eng
Schlagworte:
Coronavirus
Coronaviruses
COVID-19
Hospitalization
Hospitals
Infectious diseases
Laboratories
Medical diagnosis
Medical prognosis
Patients
predictive
progression
Public health
Risk factors
SARS-CoV-2
Sepsis
Severe acute respiratory syndrome coronavirus 2
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Zusammenfassung:Early diagnosis and treatment are crucial for the survival of severe Coronavirus Disease 2019 (COVID-19) patients, but data with regard to risk factors for disease progression from milder COVID-19 to severe COVID-19 remain scarce. We conducted a retrospective analysis on 116 patients. Three factors were observed to be independently associated with progression to severe COVID-19 during 14 days after admission: (a) age 65 years or older (hazard ratio [HR] = 8.456; 95% CI: 2.706-26.426); (b) creatine kinase (CK) ≥ 180 U/L (HR = 3.667; 95% CI: 1.253-10.733); and (c) CD4+ T-cell counts
ISSN:2391-5463
2391-5463
DOI:10.1515/med-2020-0184