The Cytokine Receptor IL-7Rα Impairs IL-2 Receptor Signaling and Constrains the In Vitro Differentiation of Foxp3+ Treg Cells

IL-7 receptor signaling is essential for the generation and maintenance of conventional T cells. Immunosuppressive Foxp3+ Treg cells, however, express uniquely low amounts of the IL-7-proprietary IL-7Rα so that they are impaired in IL-7 signaling. Because Treg cells depend on IL-2, the loss of IL-7R...

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Veröffentlicht in:	iScience 2020-08, Vol.23 (8), p.101421-101421, Article 101421
Hauptverfasser:	Waickman, Adam T., Keller, Hilary R., Kim, Tae-Hyoun, Luckey, Megan A., Tai, Xuguang, Hong, Changwan, Molina-París, Carmen, Walsh, Scott T.R., Park, Jung-Hyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Immunology Molecular Biology Multidisciplinary Sciences Science & Technology Science & Technology - Other Topics
Online-Zugang:	Volltext
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