Comparison Between Clopidogrel and Prasugrel Associated With CYP2C19 Genotypes in Patients Receiving Percutaneous Coronary Intervention in a Japanese Population

Background:The association between cytochrome P450 (CYP) 2C19 genotypes and adverse events in patients treated with clopidogrel or prasugrel after percutaneous coronary intervention (PCI) in the Japanese population is unclear.Methods and Results:This study consisted of 1,580 patients whoseCYP2C19gen...

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Veröffentlicht in:	Circulation Journal 2020/08/25, Vol.84(9), pp.1575-1581
Hauptverfasser:	Sawayama, Yuichi, Yamamoto, Takashi, Tomita, Yukinori, Asada, Kohei, Yagi, Noriaki, Fukuyama, Megumi, Miyamoto, Akashi, Sakai, Hiroshi, Ozawa, Tomoya, Isono, Tetsuichiro, Hira, Daiki, Terada, Tomohiro, Horie, Minoru, Nakagawa, Yoshihisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alleles Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology Clopidogrel Clopidogrel - adverse effects Coronary Thrombosis - chemically induced Coronary Thrombosis - epidemiology Coronary Thrombosis - genetics CYP2C19 Cytochrome P-450 CYP2C19 - genetics Female Follow-Up Studies Genotype Hemorrhage - chemically induced Hemorrhage - epidemiology Hemorrhage - genetics Humans Japan - epidemiology Life Sciences & Biomedicine Loss of Function Mutation Male Middle Aged Myocardial Infarction - chemically induced Myocardial Infarction - epidemiology Myocardial Infarction - genetics P2Y12 inhibitor Percutaneous coronary intervention Percutaneous Coronary Intervention - adverse effects Platelet Aggregation Inhibitors - adverse effects Prasugrel Prasugrel Hydrochloride - adverse effects Retrospective Studies Science & Technology Stroke - chemically induced Stroke - epidemiology Stroke - genetics Treatment Outcome
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