Significance of EGFR/HER2 Expression and PIK3CA Mutations in Giant Cell Tumour of Bone Development

Giant Cell Tumour of Bone (GCTB) is a rare bone tumour. Locally aggressive and recurrent, it might evolve into pulmonary metastases. Our present work is aimed at investigating the involvement of the epidermal growth factor receptor (ErbB) family and its downstream effectors in the development and re...

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Veröffentlicht in:	BioMed research international 2020-08, Vol.2020 (2020), p.1-11, Article 2931784
Hauptverfasser:	Aifa, Sami, Keskes, Hassib, Rebai, Mohamed Ali, Slimi, Fathia, Miled, Nabil, Jemaà, Mohamed, Charfi, Slim, Amri, Raja, Abdelwahed, Mayssa
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antigens Biotechnology & Applied Microbiology Bone tumors Cancer Cancer and Oncology Cancer och onkologi Cell growth Clinical Medicine Cloning Deoxyribonucleic acid DNA Epidermal growth factor Epidermal growth factor receptors ErbB protein ErbB-2 protein Frameshift mutation Gene expression Genes Genetic aspects Genetic testing Growth factors Health aspects Kinases Klinisk medicin Life Sciences & Biomedicine Medical and Health Sciences Medicin och hälsovetenskap Medicine, Research & Experimental Metastases Missense mutation Mutation Patients Phenols Polymers Protein kinase Proteins PTEN protein Research & Experimental Medicine Science & Technology Surgery TRANCE protein Tumors
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