MCUb Induction Protects the Heart From Postischemic Remodeling

Rationale: Mitochondrial Ca(2+)loading augments oxidative metabolism to match functional demands during times of increased work or injury. However, mitochondrial Ca(2+)overload also directly causes mitochondrial rupture and cardiomyocyte death during ischemia-reperfusion injury by inducing mitochond...

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Veröffentlicht in:	Circulation research 2020-07, Vol.127 (3), p.379-390
Hauptverfasser:	Huo, Jiuzhou, Lu, Shan, Kwong, Jennifer Q., Bround, Michael J., Grimes, Kelly M., Sargent, Michelle A., Brown, Milton E., Davis, Michael E., Bers, Donald M., Molkentin, Jeffery D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism Calcium Signaling Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology Cell Death Cell Line Disease Models, Animal Female Fibroblasts - metabolism Fibroblasts - pathology Hematology Hindlimb - blood supply Ischemic Preconditioning Life Sciences & Biomedicine Male Membrane Proteins - genetics Membrane Proteins - metabolism Mice, Inbred C57BL Mice, Knockout Mitochondria, Heart - metabolism Mitochondria, Heart - pathology Mitochondrial Permeability Transition Pore - metabolism Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocardial Infarction - physiopathology Myocardial Infarction - prevention & control Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - physiopathology Myocardial Reperfusion Injury - prevention & control Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Peripheral Vascular Disease Science & Technology Ventricular Remodeling
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