Air pollution and family related determinants of asthma onset and persistent wheezing in children: nationwide case-control study
OBJECTIVE To identify risk factors (air pollution and family related) for the onset of asthma and persistent wheezing in children. DESIGN Nationwide case-control study. SETTING Denmark. PARTICIPANTS All Danish children born from 1997 to 2014 and followed for asthma onset and persistent wheezing from...
Gespeichert in:
| Veröffentlicht in: | BMJ (Online) 2020-08, Vol.370, p.m2791-m2791, Article 2791 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | m2791 |
|---|---|
| container_issue | |
| container_start_page | m2791 |
| container_title | BMJ (Online) |
| container_volume | 370 |
| creator | Holst, Gitte J. Pedersen, Carsten B. Thygesen, Malene Brandt, Jorgen Geels, Camilla Bonlokke, Jakob H. Sigsgaard, Torben |
| description | OBJECTIVE
To identify risk factors (air pollution and family related) for the onset of asthma and persistent wheezing in children.
DESIGN
Nationwide case-control study.
SETTING
Denmark.
PARTICIPANTS
All Danish children born from 1997 to 2014 and followed for asthma onset and persistent wheezing from age 1 year to 15 years.
MAIN OUTCOME MEASURE
Onset of asthma and persistent wheezing.
RESULTS
A higher incidence of asthma was found in children of parents with asthma (adjusted hazard ratio 2.29 (95% confidence interval 2.22 to 2.35) and mothers who smoked during pregnancy (1.20, 1.18 to 1.22), whereas a lower incidence was found in children of parents with high educational attainment (0.72, 0.69 to 0.75) and high incomes (0.85, 0.81 to 0.89). Exposure to particulate matter |
| doi_str_mv | 10.1136/bmj.m2791 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_webof</sourceid><recordid>TN_cdi_webofscience_primary_000562693600003</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2435387569</sourcerecordid><originalsourceid>FETCH-LOGICAL-c380t-4f3b6997c2d46c201e761c9455b58e25b11e3ac19a1c14ddb15cc332710dc6c63</originalsourceid><addsrcrecordid>eNqNkU2LFDEQhoMo7rDuwX8Q8KJIr0nnq-NBWAZXhQUvCt6adFK9k6U7GZO0w3jyp29mZlnQk6cK1FMPVXkReknJJaVMvhvmu8u5VZo-QSuqhGxox9hTtCJa6EYw8eMMXeTsB0Kk4B0h_Dk6Y21HpeJqhf5c-YS3cZqW4mPAJjg8mtlPe5xgMgUcdlAgzT6YUDKOIza5bGaDY8hQjvwWUva5QCh4twH47cMt9gHbjZ9cgvAeB3Nw77wDbE2GxsZQUpxwLovbv0DPRjNluHio5-j79cdv68_NzddPX9ZXN41lHSkNH9kgtVa2dVzallBQklrNhRhEB60YKAVmLNWGWsqdG6iwlrFWUeKstJKdow8n73YZZnC2rpvM1G-Tn03a99H4_u9O8Jv-Nv7qFWeKa1UFrx8EKf5cIJd-9tnCNJkAccl9y5lkWjPNK_rqH_QuLinU8w6UYF2NSVfqzYmyKeacYHxchpL-EG1fo-2P0Va2O7E7GOKYrYdg4ZEnhAjZVqWsL8LWvhx_fB2XUOro2_8fZfeD_blT</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2435387569</pqid></control><display><type>article</type><title>Air pollution and family related determinants of asthma onset and persistent wheezing in children: nationwide case-control study</title><source>JSTOR Archive Collection A-Z Listing</source><source>Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>Web of Science - Social Sciences Citation Index – 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><creator>Holst, Gitte J. ; Pedersen, Carsten B. ; Thygesen, Malene ; Brandt, Jorgen ; Geels, Camilla ; Bonlokke, Jakob H. ; Sigsgaard, Torben</creator><creatorcontrib>Holst, Gitte J. ; Pedersen, Carsten B. ; Thygesen, Malene ; Brandt, Jorgen ; Geels, Camilla ; Bonlokke, Jakob H. ; Sigsgaard, Torben</creatorcontrib><description>OBJECTIVE
To identify risk factors (air pollution and family related) for the onset of asthma and persistent wheezing in children.
DESIGN
Nationwide case-control study.
SETTING
Denmark.
PARTICIPANTS
All Danish children born from 1997 to 2014 and followed for asthma onset and persistent wheezing from age 1 year to 15 years.
MAIN OUTCOME MEASURE
Onset of asthma and persistent wheezing.
RESULTS
A higher incidence of asthma was found in children of parents with asthma (adjusted hazard ratio 2.29 (95% confidence interval 2.22 to 2.35) and mothers who smoked during pregnancy (1.20, 1.18 to 1.22), whereas a lower incidence was found in children of parents with high educational attainment (0.72, 0.69 to 0.75) and high incomes (0.85, 0.81 to 0.89). Exposure to particulate matter <= 2.5 mu m (PM2.5) and <= 10 mu m (PM10) and nitrogen dioxide was associated with an increased risk of asthma and persistent wheezing, with hazard ratios per 5 mu g/m(3) increase in pollutant concentrations 1.05 (1.03 to 1.07) for PM2.5, 1.04 (1.02 to 1.06) for PM10, and 1.04 (1.03 to 1.04) for nitrogen dioxide. Only the positive association of PM2.5 with asthma and persistent wheezing remained robust across the different models and in sensitivity analyses.
CONCLUSIONS
The findings of this study suggest that children exposed to higher levels of PM2.5 are more likely to develop asthma and persistent wheezing than children who are not exposed. Other risk factors associated with these outcomes were parental asthma, parental education, and maternal smoking during pregnancy.</description><identifier>ISSN: 0959-535X</identifier><identifier>ISSN: 0959-8146</identifier><identifier>ISSN: 1756-1833</identifier><identifier>ISSN: 0959-8138</identifier><identifier>EISSN: 1756-1833</identifier><identifier>DOI: 10.1136/bmj.m2791</identifier><identifier>PMID: 32816747</identifier><language>eng</language><publisher>LONDON: Bmj Publishing Group</publisher><subject>Air pollution ; Asthma ; Children ; Education ; Families & family life ; General & Internal Medicine ; Life Sciences & Biomedicine ; Medicine, General & Internal ; Nitrogen dioxide ; Particulate matter ; Pollutants ; Population ; Pregnancy ; Prescription drugs ; Risk factors ; Science & Technology ; Sensitivity analysis ; Smoking ; Socioeconomic factors ; Survival analysis ; Variables ; Wheezing</subject><ispartof>BMJ (Online), 2020-08, Vol.370, p.m2791-m2791, Article 2791</ispartof><rights>2020 Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. BMJ This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. 2020 BMJ</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>60</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000562693600003</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c380t-4f3b6997c2d46c201e761c9455b58e25b11e3ac19a1c14ddb15cc332710dc6c63</citedby><cites>FETCH-LOGICAL-c380t-4f3b6997c2d46c201e761c9455b58e25b11e3ac19a1c14ddb15cc332710dc6c63</cites><orcidid>0000-0002-2043-7571 ; 0000-0003-2077-8533 ; 0000-0003-2549-1750 ; 0000-0002-7580-9547 ; 0000-0001-5717-099X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,781,785,886,27929,27930,28253,28254</link.rule.ids></links><search><creatorcontrib>Holst, Gitte J.</creatorcontrib><creatorcontrib>Pedersen, Carsten B.</creatorcontrib><creatorcontrib>Thygesen, Malene</creatorcontrib><creatorcontrib>Brandt, Jorgen</creatorcontrib><creatorcontrib>Geels, Camilla</creatorcontrib><creatorcontrib>Bonlokke, Jakob H.</creatorcontrib><creatorcontrib>Sigsgaard, Torben</creatorcontrib><title>Air pollution and family related determinants of asthma onset and persistent wheezing in children: nationwide case-control study</title><title>BMJ (Online)</title><addtitle>BMJ-BRIT MED J</addtitle><description>OBJECTIVE
To identify risk factors (air pollution and family related) for the onset of asthma and persistent wheezing in children.
DESIGN
Nationwide case-control study.
SETTING
Denmark.
PARTICIPANTS
All Danish children born from 1997 to 2014 and followed for asthma onset and persistent wheezing from age 1 year to 15 years.
MAIN OUTCOME MEASURE
Onset of asthma and persistent wheezing.
RESULTS
A higher incidence of asthma was found in children of parents with asthma (adjusted hazard ratio 2.29 (95% confidence interval 2.22 to 2.35) and mothers who smoked during pregnancy (1.20, 1.18 to 1.22), whereas a lower incidence was found in children of parents with high educational attainment (0.72, 0.69 to 0.75) and high incomes (0.85, 0.81 to 0.89). Exposure to particulate matter <= 2.5 mu m (PM2.5) and <= 10 mu m (PM10) and nitrogen dioxide was associated with an increased risk of asthma and persistent wheezing, with hazard ratios per 5 mu g/m(3) increase in pollutant concentrations 1.05 (1.03 to 1.07) for PM2.5, 1.04 (1.02 to 1.06) for PM10, and 1.04 (1.03 to 1.04) for nitrogen dioxide. Only the positive association of PM2.5 with asthma and persistent wheezing remained robust across the different models and in sensitivity analyses.
CONCLUSIONS
The findings of this study suggest that children exposed to higher levels of PM2.5 are more likely to develop asthma and persistent wheezing than children who are not exposed. Other risk factors associated with these outcomes were parental asthma, parental education, and maternal smoking during pregnancy.</description><subject>Air pollution</subject><subject>Asthma</subject><subject>Children</subject><subject>Education</subject><subject>Families & family life</subject><subject>General & Internal Medicine</subject><subject>Life Sciences & Biomedicine</subject><subject>Medicine, General & Internal</subject><subject>Nitrogen dioxide</subject><subject>Particulate matter</subject><subject>Pollutants</subject><subject>Population</subject><subject>Pregnancy</subject><subject>Prescription drugs</subject><subject>Risk factors</subject><subject>Science & Technology</subject><subject>Sensitivity analysis</subject><subject>Smoking</subject><subject>Socioeconomic factors</subject><subject>Survival analysis</subject><subject>Variables</subject><subject>Wheezing</subject><issn>0959-535X</issn><issn>0959-8146</issn><issn>1756-1833</issn><issn>0959-8138</issn><issn>1756-1833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>ARHDP</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkU2LFDEQhoMo7rDuwX8Q8KJIr0nnq-NBWAZXhQUvCt6adFK9k6U7GZO0w3jyp29mZlnQk6cK1FMPVXkReknJJaVMvhvmu8u5VZo-QSuqhGxox9hTtCJa6EYw8eMMXeTsB0Kk4B0h_Dk6Y21HpeJqhf5c-YS3cZqW4mPAJjg8mtlPe5xgMgUcdlAgzT6YUDKOIza5bGaDY8hQjvwWUva5QCh4twH47cMt9gHbjZ9cgvAeB3Nw77wDbE2GxsZQUpxwLovbv0DPRjNluHio5-j79cdv68_NzddPX9ZXN41lHSkNH9kgtVa2dVzallBQklrNhRhEB60YKAVmLNWGWsqdG6iwlrFWUeKstJKdow8n73YZZnC2rpvM1G-Tn03a99H4_u9O8Jv-Nv7qFWeKa1UFrx8EKf5cIJd-9tnCNJkAccl9y5lkWjPNK_rqH_QuLinU8w6UYF2NSVfqzYmyKeacYHxchpL-EG1fo-2P0Va2O7E7GOKYrYdg4ZEnhAjZVqWsL8LWvhx_fB2XUOro2_8fZfeD_blT</recordid><startdate>20200819</startdate><enddate>20200819</enddate><creator>Holst, Gitte J.</creator><creator>Pedersen, Carsten B.</creator><creator>Thygesen, Malene</creator><creator>Brandt, Jorgen</creator><creator>Geels, Camilla</creator><creator>Bonlokke, Jakob H.</creator><creator>Sigsgaard, Torben</creator><general>Bmj Publishing Group</general><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group Ltd</general><scope>17B</scope><scope>AOWDO</scope><scope>ARHDP</scope><scope>BLEPL</scope><scope>DTL</scope><scope>DVR</scope><scope>EGQ</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2043-7571</orcidid><orcidid>https://orcid.org/0000-0003-2077-8533</orcidid><orcidid>https://orcid.org/0000-0003-2549-1750</orcidid><orcidid>https://orcid.org/0000-0002-7580-9547</orcidid><orcidid>https://orcid.org/0000-0001-5717-099X</orcidid></search><sort><creationdate>20200819</creationdate><title>Air pollution and family related determinants of asthma onset and persistent wheezing in children: nationwide case-control study</title><author>Holst, Gitte J. ; Pedersen, Carsten B. ; Thygesen, Malene ; Brandt, Jorgen ; Geels, Camilla ; Bonlokke, Jakob H. ; Sigsgaard, Torben</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-4f3b6997c2d46c201e761c9455b58e25b11e3ac19a1c14ddb15cc332710dc6c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Air pollution</topic><topic>Asthma</topic><topic>Children</topic><topic>Education</topic><topic>Families & family life</topic><topic>General & Internal Medicine</topic><topic>Life Sciences & Biomedicine</topic><topic>Medicine, General & Internal</topic><topic>Nitrogen dioxide</topic><topic>Particulate matter</topic><topic>Pollutants</topic><topic>Population</topic><topic>Pregnancy</topic><topic>Prescription drugs</topic><topic>Risk factors</topic><topic>Science & Technology</topic><topic>Sensitivity analysis</topic><topic>Smoking</topic><topic>Socioeconomic factors</topic><topic>Survival analysis</topic><topic>Variables</topic><topic>Wheezing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Holst, Gitte J.</creatorcontrib><creatorcontrib>Pedersen, Carsten B.</creatorcontrib><creatorcontrib>Thygesen, Malene</creatorcontrib><creatorcontrib>Brandt, Jorgen</creatorcontrib><creatorcontrib>Geels, Camilla</creatorcontrib><creatorcontrib>Bonlokke, Jakob H.</creatorcontrib><creatorcontrib>Sigsgaard, Torben</creatorcontrib><collection>Web of Knowledge</collection><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science - Social Sciences Citation Index – 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Social Sciences Citation Index</collection><collection>Web of Science Primary (SCIE, SSCI & AHCI)</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ (Online)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holst, Gitte J.</au><au>Pedersen, Carsten B.</au><au>Thygesen, Malene</au><au>Brandt, Jorgen</au><au>Geels, Camilla</au><au>Bonlokke, Jakob H.</au><au>Sigsgaard, Torben</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Air pollution and family related determinants of asthma onset and persistent wheezing in children: nationwide case-control study</atitle><jtitle>BMJ (Online)</jtitle><stitle>BMJ-BRIT MED J</stitle><date>2020-08-19</date><risdate>2020</risdate><volume>370</volume><spage>m2791</spage><epage>m2791</epage><pages>m2791-m2791</pages><artnum>2791</artnum><issn>0959-535X</issn><issn>0959-8146</issn><issn>1756-1833</issn><issn>0959-8138</issn><eissn>1756-1833</eissn><abstract>OBJECTIVE
To identify risk factors (air pollution and family related) for the onset of asthma and persistent wheezing in children.
DESIGN
Nationwide case-control study.
SETTING
Denmark.
PARTICIPANTS
All Danish children born from 1997 to 2014 and followed for asthma onset and persistent wheezing from age 1 year to 15 years.
MAIN OUTCOME MEASURE
Onset of asthma and persistent wheezing.
RESULTS
A higher incidence of asthma was found in children of parents with asthma (adjusted hazard ratio 2.29 (95% confidence interval 2.22 to 2.35) and mothers who smoked during pregnancy (1.20, 1.18 to 1.22), whereas a lower incidence was found in children of parents with high educational attainment (0.72, 0.69 to 0.75) and high incomes (0.85, 0.81 to 0.89). Exposure to particulate matter <= 2.5 mu m (PM2.5) and <= 10 mu m (PM10) and nitrogen dioxide was associated with an increased risk of asthma and persistent wheezing, with hazard ratios per 5 mu g/m(3) increase in pollutant concentrations 1.05 (1.03 to 1.07) for PM2.5, 1.04 (1.02 to 1.06) for PM10, and 1.04 (1.03 to 1.04) for nitrogen dioxide. Only the positive association of PM2.5 with asthma and persistent wheezing remained robust across the different models and in sensitivity analyses.
CONCLUSIONS
The findings of this study suggest that children exposed to higher levels of PM2.5 are more likely to develop asthma and persistent wheezing than children who are not exposed. Other risk factors associated with these outcomes were parental asthma, parental education, and maternal smoking during pregnancy.</abstract><cop>LONDON</cop><pub>Bmj Publishing Group</pub><pmid>32816747</pmid><doi>10.1136/bmj.m2791</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-2043-7571</orcidid><orcidid>https://orcid.org/0000-0003-2077-8533</orcidid><orcidid>https://orcid.org/0000-0003-2549-1750</orcidid><orcidid>https://orcid.org/0000-0002-7580-9547</orcidid><orcidid>https://orcid.org/0000-0001-5717-099X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0959-535X |
| ispartof | BMJ (Online), 2020-08, Vol.370, p.m2791-m2791, Article 2791 |
| issn | 0959-535X 0959-8146 1756-1833 0959-8138 1756-1833 |
| language | eng |
| recordid | cdi_webofscience_primary_000562693600003 |
| source | JSTOR Archive Collection A-Z Listing; Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; Web of Science - Social Sciences Citation Index – 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /> |
| subjects | Air pollution Asthma Children Education Families & family life General & Internal Medicine Life Sciences & Biomedicine Medicine, General & Internal Nitrogen dioxide Particulate matter Pollutants Population Pregnancy Prescription drugs Risk factors Science & Technology Sensitivity analysis Smoking Socioeconomic factors Survival analysis Variables Wheezing |
| title | Air pollution and family related determinants of asthma onset and persistent wheezing in children: nationwide case-control study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-14T11%3A35%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_webof&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Air%20pollution%20and%20family%20related%20determinants%20of%20asthma%20onset%20and%20persistent%20wheezing%20in%20children:%20nationwide%20case-control%20study&rft.jtitle=BMJ%20(Online)&rft.au=Holst,%20Gitte%20J.&rft.date=2020-08-19&rft.volume=370&rft.spage=m2791&rft.epage=m2791&rft.pages=m2791-m2791&rft.artnum=2791&rft.issn=0959-535X&rft.eissn=1756-1833&rft_id=info:doi/10.1136/bmj.m2791&rft_dat=%3Cproquest_webof%3E2435387569%3C/proquest_webof%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2435387569&rft_id=info:pmid/32816747&rfr_iscdi=true |