Toll-like receptor distribution in colonic epithelium and lamina propria is disrupted in HIV viremic, immune success, and failure

DESIGN:Since intestinal immunity and the microbiome are disrupted in HIV disease, we studied the abundance of innate immune sensors, Toll-like receptors (TLRs), in the mucosa of participants with viremia, prior to antiretroviral therapy (ART), immune success (>500 CD4 T cells/μl after 2 years of...

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Veröffentlicht in:	AIDS (London) 2020-05, Vol.34 (6), p.815-826
Hauptverfasser:	McCausland, Marie R., Cruz-Lebrón, Angélica, Pilch-Cooper, Heather A., Howell, Scott, Albert, Jeffrey M., Park, Young S., Levine, Alan D.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Anti-HIV Agents - therapeutic use Antiretroviral Therapy, Highly Active - methods Case-Control Studies Enzyme-Linked Immunosorbent Assay Epithelium HIV Infections - drug therapy HIV Infections - immunology HIV Infections - metabolism Humans Immunology Infectious Diseases Intestinal Mucosa - immunology Life Sciences & Biomedicine Mucous Membrane - immunology Science & Technology Toll-Like Receptor 7 - blood Toll-Like Receptor 9 Toll-Like Receptors - blood Toll-Like Receptors - metabolism Viral Load Viremia - immunology Virology
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Zusammenfassung:	DESIGN:Since intestinal immunity and the microbiome are disrupted in HIV disease, we studied the abundance of innate immune sensors, Toll-like receptors (TLRs), in the mucosa of participants with viremia, prior to antiretroviral therapy (ART), immune success (>500 CD4 T cells/μl after 2 years of ART; suppressed viremia), and immune failure (
ISSN:	0269-9370 1473-5571
DOI:	10.1097/QAD.0000000000002499