BTN3A1 governs antitumor responses by coordinating alpha beta and gamma delta T cells

Gamma delta (gamma delta) T cells infiltrate most human tumors, but current immunotherapies fail to exploit their in situ major histocompatibility complex-independent tumoricidal potential. Activation of gamma delta T cells can be elicited by butyrophilin and butyrophilin-like molecules that are str...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 2020-08, Vol.369 (6506), p.942
Hauptverfasser: Payne, Kyle K., Mine, Jessica A., Biswas, Subir, Chaurio, Ricardo A., Perales-Puchalt, Alfredo, Anadon, Carmen M., Costich, Tara Lee, Harro, Carly M., Walrath, Jennifer, Ming, Qianqian, Tcyganov, Evgenii, Buras, Andrea L., Rigolizzo, Kristen E., Mandal, Gunjan, Lajoie, Jason, Ophir, Michael, Tchou, Julia, Marchion, Douglas, Luca, Vincent C., Bobrowicz, Piotr, McLaughlin, Brooke, Eskiocak, Ugur, Schmidt, Michael, Cubillos-Ruiz, Juan R., Rodriguez, Paulo C., Gabrilovich, Dmitry, Conejo-Garcia, Jose R.
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