Inhibition of Phosphatidylinositol 3-Kinase γ by IPI-549 Attenuates Abdominal Aortic Aneurysm Formation in Mice

The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signalling pathway plays a pivotal role in abdominal aortic aneurysm (AAA). However, systemic inhibition of this pathway causes serious side effects, thus limiting the clinical use of pan-PI3K inhibitors. In this study, it was hypothesi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of vascular and endovascular surgery 2020-08, Vol.60 (2), p.254-263
Hauptverfasser:	Liu, Rui, Huang, Jianhua, Ge, Yingbin, Liu, Shuai, Huang, Tingting, Cai, Huoying, Pan, Baihong, Zhang, Qi, Yang, Pu, Liao, Mingmei, Xu, Baohui, Wang, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdominal aortic aneurysm Aged AKT Animals Aorta, Abdominal - drug effects Aorta, Abdominal - enzymology Aorta, Abdominal - pathology Aortic Aneurysm, Abdominal - enzymology Aortic Aneurysm, Abdominal - pathology Aortic Aneurysm, Abdominal - prevention & control Cardiovascular System & Cardiology Case-Control Studies Class Ib Phosphatidylinositol 3-Kinase - metabolism Disease Models, Animal Experimental animal models Female Humans Inflammation Isoquinolines - pharmacology Isoquinolines - therapeutic use Life Sciences & Biomedicine Lymphocytes Macrophages Macrophages - drug effects Macrophages - enzymology Male Mice, Inbred C57BL Middle Aged Peripheral Vascular Disease Phosphatidylinositol 3-kinase γ Phosphorylation Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins c-akt - metabolism Pyrazoles - pharmacology Pyrazoles - therapeutic use Pyrimidines - pharmacology Pyrimidines - therapeutic use Science & Technology Surgery T-Lymphocytes - drug effects T-Lymphocytes - enzymology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!