Targeting of inflammatory pathways with R2CHOP in high-risk DLBCL

Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma, and front line therapies have not improved overall outcomes since the advent of immunochemotherapy. By pairing DNA and gene expression data with clinical response data, we identified a high-risk subset of non-GCB DLBCL patients chara...

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Veröffentlicht in:	Leukemia 2021-02, Vol.35 (2), p.522-533
Hauptverfasser:	Hartert, Keenan T., Wenzl, Kerstin, Krull, Jordan E., Manske, Michelle, Sarangi, Vivekananda, Asmann, Yan, Larson, Melissa C., Maurer, Matthew J., Slager, Susan, Macon, William R., King, Rebecca L., Feldman, Andrew L., Gandhi, Anita K., Link, Brian K., Habermann, Thomas M., Yang, Zhi-Zhang, Ansell, Stephen M., Cerhan, James R., Witzig, Thomas E., Nowakowski, Grzegorz S., Novak, Anne J.
Format:	Artikel
Sprache:	eng
Schlagworte:	38/39 45/23 631/67/1990/291/1621/1915 631/67/69 692/308/575 Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols - therapeutic use B-cell lymphoma Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cancer Research Care and treatment Critical Care Medicine Cyclophosphamide - administration & dosage Deoxyribonucleic acid Development and progression DNA Doxorubicin - administration & dosage Female Follow-Up Studies Gene expression Gene Expression Regulation, Neoplastic - drug effects Gene mutations Genetic aspects Genomics Health aspects Hematology Humans Immunomodulation Inflammation Intensive Interferon regulatory factor 4 Internal Medicine Lenalidomide - administration & dosage Life Sciences & Biomedicine Lymphocytes B Lymphoma Lymphoma, Large B-Cell, Diffuse - drug therapy Lymphoma, Large B-Cell, Diffuse - immunology Lymphoma, Large B-Cell, Diffuse - pathology Lymphomas Male Medicine Medicine & Public Health Middle Aged Mutation MyD88 protein NF-κB protein Oncology Phenotypes Prednisone - administration & dosage Prognosis Retrospective Studies Risk Rituximab - administration & dosage Science & Technology Signatures Survival Rate Vincristine - administration & dosage Young Adult
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