The SLC25 Carrier Family: Important Transport Proteins in Mitochondrial Physiology and Pathology

The SLC25 Carrier Family: Important Transport Proteins in Mitochondrial Physiology and Pathology

Members of the mitochondrial carrier family (SLC25) transport a variety of compounds across the inner membrane of mitochondria. These transport steps provide building blocks for the cell and link the pathways of the mitochondrial matrix and cytosol. An increasing number of diseases and pathologies h...

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Veröffentlicht in:Physiology (Bethesda, Md.) Md.), 2020-09, Vol.35 (5), p.302-327
Hauptverfasser: Kunji, Edmund R. S., King, Martin S., Ruprecht, Jonathan J., Thangaratnarajah, Chancievan
Format: Artikel
Sprache:eng
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Zusammenfassung:Members of the mitochondrial carrier family (SLC25) transport a variety of compounds across the inner membrane of mitochondria. These transport steps provide building blocks for the cell and link the pathways of the mitochondrial matrix and cytosol. An increasing number of diseases and pathologies has been associated with their dysfunction. In this review, the molecular basis of these diseases is explained based on our current understanding of their transport mechanism.
ISSN:1548-9213
1548-9221
DOI:10.1152/physiol.00009.2020