The effect of autologous Achilles bursal tissue implants in tendon-to-bone healing of rotator cuff tears in rats
The aim of this study was to investigate the influence of autologous bursal tissue derived from the Achilles bursa on tendon-to-bone healing after rotator cuff tear repair in a rat model. A total of 136 Sprague-Dawley rats were randomly assigned to either an untreated or a bursal tissue application...
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| Veröffentlicht in: | Journal of shoulder and elbow surgery 2020-09, Vol.29 (9), p.1892-1900 |
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| container_title | Journal of shoulder and elbow surgery |
| container_volume | 29 |
| creator | Ficklscherer, Andreas Zhang, Anja Z. Beer, Thomas Gülecyüz, Mehmet F. Klar, Roland M. Safi, Elem Woiczinski, Matthias Jansson, Volkmar Müller, Peter E. |
| description | The aim of this study was to investigate the influence of autologous bursal tissue derived from the Achilles bursa on tendon-to-bone healing after rotator cuff tear repair in a rat model.
A total of 136 Sprague-Dawley rats were randomly assigned to either an untreated or a bursal tissue application group or biomechanical testing and histologic testing after rotator cuff repair. After separating the supraspinatus tendon close to the greater tuberosity, the tendon was reattached either unaltered or with a bursal tissue interposition sewn onto the interface. Immunohistologic analysis was performed 1 and 7 weeks after supraspinatus tendon reinsertion. Biomechanical testing of the tendon occurred 6 and 7 weeks after reinsertion.
Immunohistologic results demonstrated a significantly higher percentage of Type II collagen (P = .04) after 1 and 7 weeks in the tendon-to-bone interface using autologous bursal tissue in comparison to control specimens. The bursa group showed a significantly higher collagen I to III quotient (P = .03) at 1 week after surgery in comparison to the 7-week postsurgery bursa groups and controls. Biomechanical assessment showed that overall tendon stiffness (P = .002) and the tendon viscoelasticity in the bursa group (P = .003) was significantly improved after 6 and 7 weeks. There was no significant difference (P = .55) in force to failure between the bursa group and the control group after 6 and 7 weeks.
Autologous bursal tissue derived from the Achilles bursa and implanted to the tendon-to-bone interface after rotator cuff repair facilitates a faster healing response to re-establish the biologic and biomechanical integrity of the rotator cuff in rats. |
| doi_str_mv | 10.1016/j.jse.2020.01.078 |
| format | Article |
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A total of 136 Sprague-Dawley rats were randomly assigned to either an untreated or a bursal tissue application group or biomechanical testing and histologic testing after rotator cuff repair. After separating the supraspinatus tendon close to the greater tuberosity, the tendon was reattached either unaltered or with a bursal tissue interposition sewn onto the interface. Immunohistologic analysis was performed 1 and 7 weeks after supraspinatus tendon reinsertion. Biomechanical testing of the tendon occurred 6 and 7 weeks after reinsertion.
Immunohistologic results demonstrated a significantly higher percentage of Type II collagen (P = .04) after 1 and 7 weeks in the tendon-to-bone interface using autologous bursal tissue in comparison to control specimens. The bursa group showed a significantly higher collagen I to III quotient (P = .03) at 1 week after surgery in comparison to the 7-week postsurgery bursa groups and controls. Biomechanical assessment showed that overall tendon stiffness (P = .002) and the tendon viscoelasticity in the bursa group (P = .003) was significantly improved after 6 and 7 weeks. There was no significant difference (P = .55) in force to failure between the bursa group and the control group after 6 and 7 weeks.
Autologous bursal tissue derived from the Achilles bursa and implanted to the tendon-to-bone interface after rotator cuff repair facilitates a faster healing response to re-establish the biologic and biomechanical integrity of the rotator cuff in rats.</description><identifier>ISSN: 1058-2746</identifier><identifier>EISSN: 1532-6500</identifier><identifier>DOI: 10.1016/j.jse.2020.01.078</identifier><identifier>PMID: 32299772</identifier><language>eng</language><publisher>NEW YORK: Elsevier Inc</publisher><subject>Achilles Tendon - transplantation ; Animals ; Biomechanical Phenomena ; biomechanical testing ; Bursa, Synovial - surgery ; Bursal tissue ; Collagen Type I - metabolism ; Collagen Type III - metabolism ; Female ; immunohistology ; Life Sciences & Biomedicine ; Models, Animal ; Orthopedics ; Random Allocation ; Rats, Sprague-Dawley ; Rotator Cuff Injuries - surgery ; rotator cuff tear ; Science & Technology ; Sport Sciences ; Surgery ; Synovial Membrane - transplantation ; tendon-to-bone healing ; Transplantation, Autologous</subject><ispartof>Journal of shoulder and elbow surgery, 2020-09, Vol.29 (9), p.1892-1900</ispartof><rights>2020 Journal of Shoulder and Elbow Surgery Board of Trustees</rights><rights>Copyright © 2020 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>10</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000560304100031</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c353t-e4c9c6437ee53eba36254ddfc0b97c1354497939a416a24b45221713ffb36f0d3</citedby><cites>FETCH-LOGICAL-c353t-e4c9c6437ee53eba36254ddfc0b97c1354497939a416a24b45221713ffb36f0d3</cites><orcidid>0000-0003-1957-3055</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jse.2020.01.078$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,28253,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32299772$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ficklscherer, Andreas</creatorcontrib><creatorcontrib>Zhang, Anja Z.</creatorcontrib><creatorcontrib>Beer, Thomas</creatorcontrib><creatorcontrib>Gülecyüz, Mehmet F.</creatorcontrib><creatorcontrib>Klar, Roland M.</creatorcontrib><creatorcontrib>Safi, Elem</creatorcontrib><creatorcontrib>Woiczinski, Matthias</creatorcontrib><creatorcontrib>Jansson, Volkmar</creatorcontrib><creatorcontrib>Müller, Peter E.</creatorcontrib><title>The effect of autologous Achilles bursal tissue implants in tendon-to-bone healing of rotator cuff tears in rats</title><title>Journal of shoulder and elbow surgery</title><addtitle>J SHOULDER ELB SURG</addtitle><addtitle>J Shoulder Elbow Surg</addtitle><description>The aim of this study was to investigate the influence of autologous bursal tissue derived from the Achilles bursa on tendon-to-bone healing after rotator cuff tear repair in a rat model.
A total of 136 Sprague-Dawley rats were randomly assigned to either an untreated or a bursal tissue application group or biomechanical testing and histologic testing after rotator cuff repair. After separating the supraspinatus tendon close to the greater tuberosity, the tendon was reattached either unaltered or with a bursal tissue interposition sewn onto the interface. Immunohistologic analysis was performed 1 and 7 weeks after supraspinatus tendon reinsertion. Biomechanical testing of the tendon occurred 6 and 7 weeks after reinsertion.
Immunohistologic results demonstrated a significantly higher percentage of Type II collagen (P = .04) after 1 and 7 weeks in the tendon-to-bone interface using autologous bursal tissue in comparison to control specimens. The bursa group showed a significantly higher collagen I to III quotient (P = .03) at 1 week after surgery in comparison to the 7-week postsurgery bursa groups and controls. Biomechanical assessment showed that overall tendon stiffness (P = .002) and the tendon viscoelasticity in the bursa group (P = .003) was significantly improved after 6 and 7 weeks. There was no significant difference (P = .55) in force to failure between the bursa group and the control group after 6 and 7 weeks.
Autologous bursal tissue derived from the Achilles bursa and implanted to the tendon-to-bone interface after rotator cuff repair facilitates a faster healing response to re-establish the biologic and biomechanical integrity of the rotator cuff in rats.</description><subject>Achilles Tendon - transplantation</subject><subject>Animals</subject><subject>Biomechanical Phenomena</subject><subject>biomechanical testing</subject><subject>Bursa, Synovial - surgery</subject><subject>Bursal tissue</subject><subject>Collagen Type I - metabolism</subject><subject>Collagen Type III - metabolism</subject><subject>Female</subject><subject>immunohistology</subject><subject>Life Sciences & Biomedicine</subject><subject>Models, Animal</subject><subject>Orthopedics</subject><subject>Random Allocation</subject><subject>Rats, Sprague-Dawley</subject><subject>Rotator Cuff Injuries - surgery</subject><subject>rotator cuff tear</subject><subject>Science & Technology</subject><subject>Sport Sciences</subject><subject>Surgery</subject><subject>Synovial Membrane - transplantation</subject><subject>tendon-to-bone healing</subject><subject>Transplantation, Autologous</subject><issn>1058-2746</issn><issn>1532-6500</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><recordid>eNqNkU1r3DAQhkVpab76A3opOhaKndGXvaKnsPQLArmkZyHLo6wWr7WV5Ib8-2qz2xxLT5rD885oniHkPYOWAeuut-02Y8uBQwushX71ipwzJXjTKYDXtQa1angvuzNykfMWALQE_pacCc617nt-Tvb3G6ToPbpCo6d2KXGKD3HJ9MZtwjRhpsOSsp1oCTkvSMNuP9m5ZBpmWnAe49yU2AxxRrpBO4X54dAnxWJLTNQt3lfMpmc-2ZKvyBtvp4zvTu8l-fn1y_36e3N79-3H-ua2cUKJ0qB02nVS9IhK4GBFx5UcR-9g0L1jQkmpey20layzXA5Scc56JrwfROdhFJfk47HvPsVfC-ZidiE7nOrnsa5nuNBM97yOqCg7oi7FnBN6s09hZ9OTYWAOos3WVNHmINoAM1V0zXw4tV-GHY4vib9mK7A6Ao84RJ9dwNnhC1ZPoToQIFmtBFuHqivEeR2XudTop_-PVvrzkcZq83fAZE6JMaR6VTPG8I89_gCMCK9w</recordid><startdate>202009</startdate><enddate>202009</enddate><creator>Ficklscherer, Andreas</creator><creator>Zhang, Anja Z.</creator><creator>Beer, Thomas</creator><creator>Gülecyüz, Mehmet F.</creator><creator>Klar, Roland M.</creator><creator>Safi, Elem</creator><creator>Woiczinski, Matthias</creator><creator>Jansson, Volkmar</creator><creator>Müller, Peter E.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1957-3055</orcidid></search><sort><creationdate>202009</creationdate><title>The effect of autologous Achilles bursal tissue implants in tendon-to-bone healing of rotator cuff tears in rats</title><author>Ficklscherer, Andreas ; Zhang, Anja Z. ; Beer, Thomas ; Gülecyüz, Mehmet F. ; Klar, Roland M. ; Safi, Elem ; Woiczinski, Matthias ; Jansson, Volkmar ; Müller, Peter E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-e4c9c6437ee53eba36254ddfc0b97c1354497939a416a24b45221713ffb36f0d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Achilles Tendon - transplantation</topic><topic>Animals</topic><topic>Biomechanical Phenomena</topic><topic>biomechanical testing</topic><topic>Bursa, Synovial - surgery</topic><topic>Bursal tissue</topic><topic>Collagen Type I - metabolism</topic><topic>Collagen Type III - metabolism</topic><topic>Female</topic><topic>immunohistology</topic><topic>Life Sciences & Biomedicine</topic><topic>Models, Animal</topic><topic>Orthopedics</topic><topic>Random Allocation</topic><topic>Rats, Sprague-Dawley</topic><topic>Rotator Cuff Injuries - surgery</topic><topic>rotator cuff tear</topic><topic>Science & Technology</topic><topic>Sport Sciences</topic><topic>Surgery</topic><topic>Synovial Membrane - transplantation</topic><topic>tendon-to-bone healing</topic><topic>Transplantation, Autologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ficklscherer, Andreas</creatorcontrib><creatorcontrib>Zhang, Anja Z.</creatorcontrib><creatorcontrib>Beer, Thomas</creatorcontrib><creatorcontrib>Gülecyüz, Mehmet F.</creatorcontrib><creatorcontrib>Klar, Roland M.</creatorcontrib><creatorcontrib>Safi, Elem</creatorcontrib><creatorcontrib>Woiczinski, Matthias</creatorcontrib><creatorcontrib>Jansson, Volkmar</creatorcontrib><creatorcontrib>Müller, Peter E.</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of shoulder and elbow surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ficklscherer, Andreas</au><au>Zhang, Anja Z.</au><au>Beer, Thomas</au><au>Gülecyüz, Mehmet F.</au><au>Klar, Roland M.</au><au>Safi, Elem</au><au>Woiczinski, Matthias</au><au>Jansson, Volkmar</au><au>Müller, Peter E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of autologous Achilles bursal tissue implants in tendon-to-bone healing of rotator cuff tears in rats</atitle><jtitle>Journal of shoulder and elbow surgery</jtitle><stitle>J SHOULDER ELB SURG</stitle><addtitle>J Shoulder Elbow Surg</addtitle><date>2020-09</date><risdate>2020</risdate><volume>29</volume><issue>9</issue><spage>1892</spage><epage>1900</epage><pages>1892-1900</pages><issn>1058-2746</issn><eissn>1532-6500</eissn><abstract>The aim of this study was to investigate the influence of autologous bursal tissue derived from the Achilles bursa on tendon-to-bone healing after rotator cuff tear repair in a rat model.
A total of 136 Sprague-Dawley rats were randomly assigned to either an untreated or a bursal tissue application group or biomechanical testing and histologic testing after rotator cuff repair. After separating the supraspinatus tendon close to the greater tuberosity, the tendon was reattached either unaltered or with a bursal tissue interposition sewn onto the interface. Immunohistologic analysis was performed 1 and 7 weeks after supraspinatus tendon reinsertion. Biomechanical testing of the tendon occurred 6 and 7 weeks after reinsertion.
Immunohistologic results demonstrated a significantly higher percentage of Type II collagen (P = .04) after 1 and 7 weeks in the tendon-to-bone interface using autologous bursal tissue in comparison to control specimens. The bursa group showed a significantly higher collagen I to III quotient (P = .03) at 1 week after surgery in comparison to the 7-week postsurgery bursa groups and controls. Biomechanical assessment showed that overall tendon stiffness (P = .002) and the tendon viscoelasticity in the bursa group (P = .003) was significantly improved after 6 and 7 weeks. There was no significant difference (P = .55) in force to failure between the bursa group and the control group after 6 and 7 weeks.
Autologous bursal tissue derived from the Achilles bursa and implanted to the tendon-to-bone interface after rotator cuff repair facilitates a faster healing response to re-establish the biologic and biomechanical integrity of the rotator cuff in rats.</abstract><cop>NEW YORK</cop><pub>Elsevier Inc</pub><pmid>32299772</pmid><doi>10.1016/j.jse.2020.01.078</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-1957-3055</orcidid></addata></record> |
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| subjects | Achilles Tendon - transplantation Animals Biomechanical Phenomena biomechanical testing Bursa, Synovial - surgery Bursal tissue Collagen Type I - metabolism Collagen Type III - metabolism Female immunohistology Life Sciences & Biomedicine Models, Animal Orthopedics Random Allocation Rats, Sprague-Dawley Rotator Cuff Injuries - surgery rotator cuff tear Science & Technology Sport Sciences Surgery Synovial Membrane - transplantation tendon-to-bone healing Transplantation, Autologous |
| title | The effect of autologous Achilles bursal tissue implants in tendon-to-bone healing of rotator cuff tears in rats |
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