An Antibody-Drug Conjugate Targeting MUC1-Associated Carbohydrate CA6 Shows Promising Antitumor Activities

Glycosylation is a complex multienzyme-related process that is frequently deregulated in cancer. Aberrant glycosylation can lead to the generation of novel tumor surface-specific glycotopes that can be targeted by antibodies. Murine DS6 mAb (muDS6) was generated from serous ovary adenocarcinoma immu...

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Veröffentlicht in:	Molecular cancer therapeutics 2020-08, Vol.19 (8), p.1660-1669
Hauptverfasser:	Nicolazzi, Celine, Caron, Anne, Tellier, Alexia, Trombe, Marc, Pinkas, Jan, Payne, Gillian, Carrez, Chantal, Guerif, Stephane, Maguin, Marie, Baffa, Raffaele, Fassan, Matteo, Adam, Julien, Mangatal-Wade, Lydie, Blanc, Veronique
Format:	Artikel
Sprache:	eng
Schlagworte:	Life Sciences & Biomedicine Oncology Science & Technology
Online-Zugang:	Volltext
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